O70150 · KCC1B_RAT

  • Protein
    Calcium/calmodulin-dependent protein kinase type 1B
  • Gene
    Pnck
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro, isoform 1 and isoform 2 phosphorylate CREB1, SYN1/synapsin I. Phosphorylates and activates CAMK1.

Catalytic activity

Activity regulation

Activated by Ca2+/calmodulin. Must be phosphorylated to be maximally active. Activated by CAMKK1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site21-29ATP (UniProtKB | ChEBI)
Binding site44ATP (UniProtKB | ChEBI)
Active site136Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functioncalmodulin binding
Molecular Functioncalmodulin-dependent protein kinase activity
Molecular Functionprotein serine kinase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Calcium/calmodulin-dependent protein kinase type 1B
  • EC number
  • Alternative names
    • CaM kinase I beta (CaM kinase IB; CaM-KI beta; CaMKI-beta)
    • Pregnancy up-regulated non-ubiquitously-expressed CaM kinase homolog

Gene names

    • Name
      Pnck

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    O70150
  • Secondary accessions
    • O08767

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000860811-343Calcium/calmodulin-dependent protein kinase type 1B
Modified residue338Phosphoserine

Post-translational modification

Isoform 1 and isoform 2 are phosphorylated by CAMKK1.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Isoform 1 is expressed in liver, heart, lung, kidney, spleen and testis. Isoform 2 is predominantly expressed in cerebrum and cerebellum.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain15-270Protein kinase
Region290-311Calmodulin-binding
Region314-343Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

O70150-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    CamKIbeta2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    343
  • Mass (Da)
    38,439
  • Last updated
    1998-08-01 v1
  • Checksum
    994D451D809A9D80
MLLLKKQTEDISSVYEIREKLGSGAFSEVMLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALQHLWISGDAALDRDILGSVSEQIQKNFARTHWKRAFNATSFLRHIRKLGQSPEGEEASRQGMTRHSHPGLGTSQSPKW

O70150-2

  • Name
    2
  • Synonyms
    CamKIbeta1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 319-343: GEEASRQGMTRHSHPGLGTSQSPKW → ALLISFPDPCPPDWPLLESPRPWV

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_012636319-343in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D86556
EMBL· GenBank· DDBJ
BAA19879.1
EMBL· GenBank· DDBJ
mRNA
AB004267
EMBL· GenBank· DDBJ
BAA28263.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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