O69830 · CHDC_STRCO

Function

function

Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate.

Catalytic activity

Cofactor

Fe-coproporphyrin III (UniProtKB | Rhea| CHEBI:68438 )

Note: Fe-coproporphyrin III acts both as a substrate and a redox cofactor.

Pathway

Porphyrin-containing compound metabolism; protoheme biosynthesis.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site145
Binding site168Fe (UniProtKB | ChEBI) of Fe-coproporphyrin III (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular Functionoxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
Biological Processheme B biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Coproheme decarboxylase
  • EC number
  • Alternative names
    • Coproheme III oxidative decarboxylase
    • Hydrogen peroxide-dependent heme synthase

Gene names

    • Name
      chdC
    • Ordered locus names
      SCO6042

Organism names

Accessions

  • Primary accession
    O69830

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004502771-243Coproheme decarboxylase

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the ChdC family. Type 2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    243
  • Mass (Da)
    28,132
  • Last updated
    1998-08-01 v1
  • Checksum
    6180412A99FD8E04
MSDDASTPAAERIPNKGKLAKDLNEVIRYTLWSVFKLKDTLPEDRAGYADEVQELFDQLAAKDVTIRGTYDLSGLRADADLMIWWHAETADQLQEAYNLFRRTKLGRALEPVWSNMALHRPAEFNRSHIPAFLADETPRNYISVYPFVRSYDWYLLPDEDRRRMLADHGKMARGYPDVRANTVASFSLGDYEWILAFEADELHRIVDLMRHLRGSEARRHVREEIPFYTGRRKDIGELVAGLA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL939126
EMBL· GenBank· DDBJ
CAA18976.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp