O69830 · CHDC_STRCO
- ProteinCoproheme decarboxylase
- GenechdC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids243 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate.
Catalytic activity
- Fe-coproporphyrin III + 2 H+ + 2 H2O2 = 2 CO2 + 4 H2O + heme bThis reaction proceeds in the forward direction.
- Fe-coproporphyrin III + H+ + H2O2 = CO2 + 2 H2O + harderoheme IIIThis reaction proceeds in the forward direction.
- H+ + H2O2 + harderoheme III = CO2 + 2 H2O + heme bThis reaction proceeds in the forward direction.
Cofactor
Note: Fe-coproporphyrin III acts both as a substrate and a redox cofactor.
Pathway
Porphyrin-containing compound metabolism; protoheme biosynthesis.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor | |
Biological Process | heme B biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCoproheme decarboxylase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces > Streptomyces albidoflavus group
Accessions
- Primary accessionO69830
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000450277 | 1-243 | Coproheme decarboxylase | |||
Sequence: MSDDASTPAAERIPNKGKLAKDLNEVIRYTLWSVFKLKDTLPEDRAGYADEVQELFDQLAAKDVTIRGTYDLSGLRADADLMIWWHAETADQLQEAYNLFRRTKLGRALEPVWSNMALHRPAEFNRSHIPAFLADETPRNYISVYPFVRSYDWYLLPDEDRRRMLADHGKMARGYPDVRANTVASFSLGDYEWILAFEADELHRIVDLMRHLRGSEARRHVREEIPFYTGRRKDIGELVAGLA |
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the ChdC family. Type 2 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length243
- Mass (Da)28,132
- Last updated1998-08-01 v1
- Checksum6180412A99FD8E04
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL939126 EMBL· GenBank· DDBJ | CAA18976.1 EMBL· GenBank· DDBJ | Genomic DNA |