O69250 · PTHP_PRIMG

Function

function

General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
P-Ser-HPr interacts with the catabolite control protein A (CcpA), forming a complex that binds to DNA at the catabolite response elements cre, operator sites preceding a large number of catabolite-regulated genes. Thus, P-Ser-HPr is a corepressor in carbon catabolite repression (CCR), a mechanism that allows bacteria to coordinate and optimize the utilization of available carbon sources. P-Ser-HPr also plays a role in inducer exclusion, in which it probably interacts with several non-PTS permeases and inhibits their transport activity (By similarity).

Activity regulation

Phosphorylation on Ser-46 inhibits the phosphoryl transfer from enzyme I to HPr.

Features

Showing features for active site.

1881020304050607080
MAQKTFTVTADSGIHARPATTLVQAASKFDSDINLEFNGKTVNLKSIMGVMSLGIQKGATITISAEGSDEADALAALEDTMSKEGLGE
TypeIDPosition(s)Description
Active site15Pros-phosphohistidine intermediate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Biological Processphosphoenolpyruvate-dependent sugar phosphotransferase system

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Phosphocarrier protein HPr
  • Alternative names
    • Histidine-containing protein

Gene names

    • Name
      ptsH

Organism names

Accessions

  • Primary accession
    O69250

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001078391-88Phosphocarrier protein HPr
Modified residue12Phosphoserine
Modified residue46Phosphoserine; by HPrK/P

Keywords

PTM databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-88HPr

Sequence similarities

Belongs to the HPr family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    88
  • Mass (Da)
    9,119
  • Last updated
    1998-08-01 v1
  • Checksum
    4EDC85C2E0B9AA3B
MAQKTFTVTADSGIHARPATTLVQAASKFDSDINLEFNGKTVNLKSIMGVMSLGIQKGATITISAEGSDEADALAALEDTMSKEGLGE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ005075
EMBL· GenBank· DDBJ
CAA06331.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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