O68690 · YSCG_YERPE

  • Protein
    Type 3 secretion system chaperone YscG
  • Gene
    yscG
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Chaperone of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:18281060, PubMed:29458689).
Along with YscE, prevents premature polymerization of the YscF/SctF needle protein within the cytoplasm (By similarity).
Is also required for stable expression of cytosolic YscF and for YscF secretion (PubMed:29458689).
May act as a scaffold to organize the assembly of YscE and YscF into the heterotrimeric complex (PubMed:18281060).
Required for Yop secretion (PubMed:11035761).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm

Names & Taxonomy

Protein names

  • Recommended name
    Type 3 secretion system chaperone YscG
  • Alternative names
    • Yersinia secretion component G
    • Yop proteins translocation protein G

Gene names

    • Name
      yscG
    • Synonyms
      Y0025
    • ORF names
      EGX46_00090
    • Ordered locus names
      YPCD1.56

Encoded on

  • Plasmid pCD1
  • Plasmid unnamed1

Organism names

  • Taxonomic identifier
  • Strains
    • KIM5 / Biovar Mediaevalis
    • C790
    • CO-92 / Biovar Orientalis
    • FDAARGOS_601
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Yersinia

Accessions

  • Primary accession
    O68690
  • Secondary accessions
    • A0A0H2VZ57
    • A0A2S9PEH8
    • A0A380SCA3
    • Q74YY2
    • Q7ARH9

Proteomes

Subcellular Location

Cytoplasm
Note: Could be a peripheral membrane protein.

Keywords

Phenotypes & Variants

Disruption phenotype

Deletion mutant has no detectable level of YopN secretion, YscF expression or YscEFG assembly, but it expresses normal levels of another Ysc component, YscJ/SctJ (PubMed:29458689).
Deletion mutant fails to secrete YopE at 37 degrees Celsius in the presence or absence of calcium (PubMed:11035761).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004584561-115Type 3 secretion system chaperone YscG

Proteomic databases

Interaction

Subunit

Component of the heterodimeric YscE-YscG chaperone (PubMed:11035761, PubMed:18281060, PubMed:29458689).
The YscE-YscG chaperone forms a stable ternary complex with YscF/SctF (PubMed:18281060).
YscG interacts with YscE and binds tightly to the C-terminal half of YscF (PubMed:11035761, PubMed:18281060).

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the YscG family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    115
  • Mass (Da)
    13,070
  • Last updated
    1998-08-01 v1
  • Checksum
    6194CE122ED1AB4B
MKYKLNVLLAEIALIGTGNHYHEEANCIAEWLHLKGEEEAVQLIRLSSLMNRGDYASALQQGNKLAYPDLEPWLALCEYRLGLGSALESRLNRLARSQDPRIQTFVNGMREQLKT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF074612
EMBL· GenBank· DDBJ
AAC69777.1
EMBL· GenBank· DDBJ
Genomic DNA
AF053946
EMBL· GenBank· DDBJ
AAC62548.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ612242
EMBL· GenBank· DDBJ
ADV16641.1
EMBL· GenBank· DDBJ
Genomic DNA
AL117189
EMBL· GenBank· DDBJ
CAB54933.1
EMBL· GenBank· DDBJ
Genomic DNA
CP033697
EMBL· GenBank· DDBJ
AYX17966.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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