O66164 · FTHS_SPHSK

Function

Catalytic activity

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site.

155850100150200250300350400450500550
TypeIDPosition(s)Description
Binding site67-74ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functionformate-tetrahydrofolate ligase activity
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Formate--tetrahydrofolate ligase
  • EC number
  • Alternative names
    • Formyltetrahydrofolate synthetase
      (FHS
      ; FTHFS
      )

Gene names

    • Name
      fhs
    • Synonyms
      ligH
    • ORF names
      SLG_12760

Organism names

Accessions

  • Primary accession
    O66164
  • Secondary accessions
    • G2IQS9
    • Q60FW9

Proteomes

Phenotypes & Variants

Disruption phenotype

Mutant cannot degrade vanillate or syringate, but it can degrade protocatechuate and 3-O-methylgallate (PubMed:9501423).
Mutant shows O-demethylation activity toward both vanillate and syringate in the presence of tetrahydrofolate, indicating that ligH is not directly involved in the O demethylation of vanillate and syringate (PubMed:15090517).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001993701-558Formate--tetrahydrofolate ligase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    558
  • Mass (Da)
    59,464
  • Last updated
    2019-05-08 v2
  • Checksum
    1DEA902749928A65
MAQGSDIEIAREAKMQNIAEVGAKVGIPQDALLNYGPYKAKLSWDFINSVQGNQDGKLILVTAINPTPAGEGKTTTTVGLADGLNRIGKKTVAALREPSLGPCFGVKGGAAGGGYAQVVPMEDINLHFTGDFHAITSANNLLAALIDNHIYWGNKLGLDPRRIAWRRVLDMNDRALRSIVNSLGGVSNGYPREDGFDITVASEVMAILCLSSDLKDLERRLGNIHAGYTRERKAVLASELNASGAMTVLLKDALQPNMVQTLENNPVLIHGGPFANIAHGCNSVLATKTALKIADYVVTEAGFGADLGAEKFFDIKCRKAGLKPSAAVIVATIRALKMHGGVDKADLGTANPEAVRKGGVNLARHIENVRQFGVPVVVAINQFITDTDEEMAMVKEIAEAAGAEAVLCSHWANGSAGTEELARKVVLHAESGSSNFAPLYEDSMPLFEKIDTIAKRIYRATEATADSSVRNKLKGWEADGFGHLPVCMAKTQYSFSTDPALRGAPTDHVVPVRDVILSAGAEFIVAVCGDIMRMPGLPKVPSADFIKLDEQGQIQGLF

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict13-14in Ref. 1; BAA25140
Sequence conflict175-176in Ref. 1; BAA25140
Sequence conflict427in Ref. 1; BAA25140

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB006079
EMBL· GenBank· DDBJ
BAA25140.1
EMBL· GenBank· DDBJ
Genomic DNA
AB186750
EMBL· GenBank· DDBJ
BAD61061.1
EMBL· GenBank· DDBJ
Genomic DNA
AP012222
EMBL· GenBank· DDBJ
BAK65951.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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