O65717 · CNGC1_ARATH

Function

function

Acts as a cyclic nucleotide-gated ion channel. Can be activated by cyclic AMP which leads to an opening of the cation channel. May be responsible for cAMP-induced calcium entry in cells and thus should be involved in the calcium signal transduction. Could transport K+, Na+ and Pb2+.

Features

Showing features for binding site.

1716100200300400500600700
TypeIDPosition(s)Description
Binding site486-610a nucleoside 3',5'-cyclic phosphate (UniProtKB | ChEBI)
Binding site557a nucleoside 3',5'-cyclic phosphate (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functioncalmodulin binding
Molecular FunctioncAMP binding
Molecular FunctioncGMP binding
Molecular Functionmonoatomic ion channel activity

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Cyclic nucleotide-gated ion channel 1
  • Short names
    AtCNGC1
  • Alternative names
    • Cyclic nucleotide- and calmodulin-regulated ion channel 1

Gene names

    • Name
      CNGC1
    • ORF names
      MFH8.6
    • Ordered locus names
      At5g53130

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    O65717

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-97Cytoplasmic
Transmembrane98-118Helical; Name=H1
Topological domain119-132Extracellular
Transmembrane133-153Helical; Name=H2
Topological domain154-187Cytoplasmic
Transmembrane188-208Helical; Name=H3
Topological domain209-220Extracellular
Transmembrane221-241Helical; Name=H4
Topological domain242-259Cytoplasmic
Transmembrane260-280Helical; Name=H5
Topological domain281-379Extracellular
Transmembrane380-400Helical; Name=H6
Topological domain401-716Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Plants exhibit an improved tolerance to Pb2+.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 21 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002193291-716Cyclic nucleotide-gated ion channel 1

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the whole plant but only weakly in roots.

Gene expression databases

Interaction

Subunit

Homotetramer or heterotetramer (Potential). Binds calmodulin-2/3/5 with a higher affinity than calmodulin-1/4.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region602-617Calmodulin-binding
Domain622-651IQ
Region689-716Disordered

Domain

The binding of calmodulin to the C-terminus might interfere with cyclic nucleotide binding and thus channel activation.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    716
  • Mass (Da)
    83,097
  • Last updated
    1998-08-01 v1
  • Checksum
    5883CA949B6E7BF2
MNFRQEKFVRFQDWKSDKTSSDVEYSGKNEIQTGIFQRTISSISDKFYRSFESSSARIKLFKRSYKSYSFKEAVSKGIGSTHKILDPQGPFLQRWNKIFVLACIIAVSLDPLFFYVPIIDDAKKCLGIDKKMEITASVLRSFTDVFYVLHIIFQFRTGFIAPSSRVFGRGVLVEDKREIAKRYLSSHFIIDILAVLPLPQMVILIIIPHMRGSSSLNTKNMLKFIVFFQYIPRFIRIYPLYKEVTRTSGILTETAWAGAAFNLFLYMLASHVFGAFWYLFSIERETVCWKQACERNNPPCISKLLYCDPETAGGNAFLNESCPIQTPNTTLFDFGIFLDALQSGVVESQDFPQKFFYCFWWGLQNLSSLGQNLKTSTYIWEICFAVFISIAGLVLFSFLIGNMQTYLQSTTTRLEEMRVKRRDAEQWMSHRLLPENLRKRIRRYEQYKWQETRGVDEENLLSNLPKDLRRDIKRHLCLALLMRVPMFEKMDEQLLDALCDRLQPVLYTEESYIVREGDPVDEMLFIMRGKLLTITTNGGRTGFLNSEYLGAGDFCGEELLTWALDPHSSSNLPISTRTVRALMEVEAFALKADDLKFVASQFRRLHSKQLRHTFRYYSQQWKTWAACFIQAAWRRYIKKKLEESLKEEENRLQDALAKEACGSSPSLGATIYASRFAANILRTIRRSGSVRKPRMPERMPPMLLQKPAEPDFNSDD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y16327
EMBL· GenBank· DDBJ
CAA76178.1
EMBL· GenBank· DDBJ
mRNA
AB025622
EMBL· GenBank· DDBJ
BAB08416.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED96311.1
EMBL· GenBank· DDBJ
Genomic DNA
AF370139
EMBL· GenBank· DDBJ
AAK43954.1
EMBL· GenBank· DDBJ
mRNA
BT000991
EMBL· GenBank· DDBJ
AAN41391.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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