O65717 · CNGC1_ARATH
- ProteinCyclic nucleotide-gated ion channel 1
- GeneCNGC1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids716 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Acts as a cyclic nucleotide-gated ion channel. Can be activated by cyclic AMP which leads to an opening of the cation channel. May be responsible for cAMP-induced calcium entry in cells and thus should be involved in the calcium signal transduction. Could transport K+, Na+ and Pb2+.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 486-610 | a nucleoside 3',5'-cyclic phosphate (UniProtKB | ChEBI) | ||||
Sequence: MFEKMDEQLLDALCDRLQPVLYTEESYIVREGDPVDEMLFIMRGKLLTITTNGGRTGFLNSEYLGAGDFCGEELLTWALDPHSSSNLPISTRTVRALMEVEAFALKADDLKFVASQFRRLHSKQL | ||||||
Binding site | 557 | a nucleoside 3',5'-cyclic phosphate (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | calmodulin binding | |
Molecular Function | cAMP binding | |
Molecular Function | cGMP binding | |
Molecular Function | monoatomic ion channel activity |
Keywords
- Molecular function
- Biological process
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameCyclic nucleotide-gated ion channel 1
- Short namesAtCNGC1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionO65717
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-97 | Cytoplasmic | ||||
Sequence: MNFRQEKFVRFQDWKSDKTSSDVEYSGKNEIQTGIFQRTISSISDKFYRSFESSSARIKLFKRSYKSYSFKEAVSKGIGSTHKILDPQGPFLQRWNK | ||||||
Transmembrane | 98-118 | Helical; Name=H1 | ||||
Sequence: IFVLACIIAVSLDPLFFYVPI | ||||||
Topological domain | 119-132 | Extracellular | ||||
Sequence: IDDAKKCLGIDKKM | ||||||
Transmembrane | 133-153 | Helical; Name=H2 | ||||
Sequence: EITASVLRSFTDVFYVLHIIF | ||||||
Topological domain | 154-187 | Cytoplasmic | ||||
Sequence: QFRTGFIAPSSRVFGRGVLVEDKREIAKRYLSSH | ||||||
Transmembrane | 188-208 | Helical; Name=H3 | ||||
Sequence: FIIDILAVLPLPQMVILIIIP | ||||||
Topological domain | 209-220 | Extracellular | ||||
Sequence: HMRGSSSLNTKN | ||||||
Transmembrane | 221-241 | Helical; Name=H4 | ||||
Sequence: MLKFIVFFQYIPRFIRIYPLY | ||||||
Topological domain | 242-259 | Cytoplasmic | ||||
Sequence: KEVTRTSGILTETAWAGA | ||||||
Transmembrane | 260-280 | Helical; Name=H5 | ||||
Sequence: AFNLFLYMLASHVFGAFWYLF | ||||||
Topological domain | 281-379 | Extracellular | ||||
Sequence: SIERETVCWKQACERNNPPCISKLLYCDPETAGGNAFLNESCPIQTPNTTLFDFGIFLDALQSGVVESQDFPQKFFYCFWWGLQNLSSLGQNLKTSTYI | ||||||
Transmembrane | 380-400 | Helical; Name=H6 | ||||
Sequence: WEICFAVFISIAGLVLFSFLI | ||||||
Topological domain | 401-716 | Cytoplasmic | ||||
Sequence: GNMQTYLQSTTTRLEEMRVKRRDAEQWMSHRLLPENLRKRIRRYEQYKWQETRGVDEENLLSNLPKDLRRDIKRHLCLALLMRVPMFEKMDEQLLDALCDRLQPVLYTEESYIVREGDPVDEMLFIMRGKLLTITTNGGRTGFLNSEYLGAGDFCGEELLTWALDPHSSSNLPISTRTVRALMEVEAFALKADDLKFVASQFRRLHSKQLRHTFRYYSQQWKTWAACFIQAAWRRYIKKKLEESLKEEENRLQDALAKEACGSSPSLGATIYASRFAANILRTIRRSGSVRKPRMPERMPPMLLQKPAEPDFNSDD |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Plants exhibit an improved tolerance to Pb2+.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 21 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000219329 | 1-716 | Cyclic nucleotide-gated ion channel 1 | |||
Sequence: MNFRQEKFVRFQDWKSDKTSSDVEYSGKNEIQTGIFQRTISSISDKFYRSFESSSARIKLFKRSYKSYSFKEAVSKGIGSTHKILDPQGPFLQRWNKIFVLACIIAVSLDPLFFYVPIIDDAKKCLGIDKKMEITASVLRSFTDVFYVLHIIFQFRTGFIAPSSRVFGRGVLVEDKREIAKRYLSSHFIIDILAVLPLPQMVILIIIPHMRGSSSLNTKNMLKFIVFFQYIPRFIRIYPLYKEVTRTSGILTETAWAGAAFNLFLYMLASHVFGAFWYLFSIERETVCWKQACERNNPPCISKLLYCDPETAGGNAFLNESCPIQTPNTTLFDFGIFLDALQSGVVESQDFPQKFFYCFWWGLQNLSSLGQNLKTSTYIWEICFAVFISIAGLVLFSFLIGNMQTYLQSTTTRLEEMRVKRRDAEQWMSHRLLPENLRKRIRRYEQYKWQETRGVDEENLLSNLPKDLRRDIKRHLCLALLMRVPMFEKMDEQLLDALCDRLQPVLYTEESYIVREGDPVDEMLFIMRGKLLTITTNGGRTGFLNSEYLGAGDFCGEELLTWALDPHSSSNLPISTRTVRALMEVEAFALKADDLKFVASQFRRLHSKQLRHTFRYYSQQWKTWAACFIQAAWRRYIKKKLEESLKEEENRLQDALAKEACGSSPSLGATIYASRFAANILRTIRRSGSVRKPRMPERMPPMLLQKPAEPDFNSDD |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in the whole plant but only weakly in roots.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 602-617 | Calmodulin-binding | ||||
Sequence: FRRLHSKQLRHTFRYY | ||||||
Domain | 622-651 | IQ | ||||
Sequence: KTWAACFIQAAWRRYIKKKLEESLKEEENR | ||||||
Region | 689-716 | Disordered | ||||
Sequence: SVRKPRMPERMPPMLLQKPAEPDFNSDD |
Domain
The binding of calmodulin to the C-terminus might interfere with cyclic nucleotide binding and thus channel activation.
Sequence similarities
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length716
- Mass (Da)83,097
- Last updated1998-08-01 v1
- Checksum5883CA949B6E7BF2
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Y16327 EMBL· GenBank· DDBJ | CAA76178.1 EMBL· GenBank· DDBJ | mRNA | ||
AB025622 EMBL· GenBank· DDBJ | BAB08416.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002688 EMBL· GenBank· DDBJ | AED96311.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF370139 EMBL· GenBank· DDBJ | AAK43954.1 EMBL· GenBank· DDBJ | mRNA | ||
BT000991 EMBL· GenBank· DDBJ | AAN41391.1 EMBL· GenBank· DDBJ | mRNA |