O65583 · UKL4_ARATH

Function

function

Involved in the pyrimidine salvage pathway. The uracil phosphoribosyltransferase (UPRT) activity, that catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate, is unsure.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.

Activity regulation

Allosterically activated by GTP.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.
Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.
Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site283GTP (UniProtKB | ChEBI)
Binding site292GTP (UniProtKB | ChEBI)
Binding site326-329GTP (UniProtKB | ChEBI)
Binding site3365-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site3615-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site381GTP (UniProtKB | ChEBI)
Binding site3875-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site392-3955-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site457-459uracil (UniProtKB | ChEBI)
Binding site4585-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functioncytidine kinase activity
Molecular FunctionGTP binding
Molecular Functionuracil phosphoribosyltransferase activity
Molecular Functionuridine kinase activity
Biological ProcessCTP salvage
Biological ProcessUMP salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uridine kinase-like protein 4

Including 2 domains:

  • Recommended name
    Putative uracil phosphoribosyltransferase
  • EC number
  • Short names
    UPRTase
  • Alternative names
    • UMP pyrophosphorylase

Gene names

    • Name
      UKL4
    • Synonyms
      UPT1
    • ORF names
      M3E9.60
    • Ordered locus names
      At4g26510

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    O65583
  • Secondary accessions
    • Q0WQS9
    • Q8LD95
    • Q9SYU2

Proteomes

Organism-specific databases

Genome annotation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001207841-469Uridine kinase-like protein 4

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region46-249Uridine kinase
Region259-469Uracil phosphoribosyltransferase

Sequence similarities

In the N-terminal section; belongs to the uridine kinase family.
In the C-terminal section; belongs to the UPRTase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    469
  • Mass (Da)
    52,639
  • Last updated
    2010-06-15 v2
  • Checksum
    E5A6357C1DF76BC7
MGSKSVVDMIEAASRAHFSGLHVNGHMNGLEPSALKETTSASEDIQRQPFVIGVAGGAASGKTTVCDMIIQQLHDQRVVLINLDSFYHNLTEEELARVHEYNFDHPDAFDTEHLLSCMEKLRQGQAVDIPKYDFKTYRSSVFRRVNPTDVIILEGILLFHDPRVRKLMNMKIFVCTDADVRLARRIKRDTVENGRDIGTVLDQYSKFVKPAFDDFILPTKKYADIIIPRGGDNHVAIDLIVQHICTKLGQHDLCKIYPNLYVIHSTFQIRGMHTLIRDSQTTKHDFVFYSDRLIRLVVEHGLGHLPFTEKQVITPTGCVYSGVDFCKRLCGVSVIRSGESMENALRACCKGIKIGKILIHREGDNGQQLVYEKLPNDISERHVLLLDPILGTGNSAVEAINLLISKGVPEGNIIFLNLISAPQGVHVVCKKFPRIKIVTSEIDNGLNEEFRVIPGMGEFGDRYFGTDDD

Sequence caution

The sequence CAA18219.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence CAB79506.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict94in Ref. 5; BAF00520

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL022223
EMBL· GenBank· DDBJ
CAA18219.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AL161565
EMBL· GenBank· DDBJ
CAB79506.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002687
EMBL· GenBank· DDBJ
AEE85211.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002687
EMBL· GenBank· DDBJ
AEE85212.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002687
EMBL· GenBank· DDBJ
ANM66905.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002687
EMBL· GenBank· DDBJ
ANM66906.1
EMBL· GenBank· DDBJ
Genomic DNA
AY086133
EMBL· GenBank· DDBJ
AAM63338.1
EMBL· GenBank· DDBJ
mRNA
BT022059
EMBL· GenBank· DDBJ
AAY25471.1
EMBL· GenBank· DDBJ
mRNA
AK228608
EMBL· GenBank· DDBJ
BAF00520.1
EMBL· GenBank· DDBJ
mRNA
AF116860
EMBL· GenBank· DDBJ
AAD28199.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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