O65404 · ERG11_ARATH

Function

function

Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.

Miscellaneous

SEQ4 or SEQ5 are unable to complement seq1 mutants.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Pathway

Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site55-56FAD (UniProtKB | ChEBI)
Binding site75-76FAD (UniProtKB | ChEBI)
Binding site83FAD (UniProtKB | ChEBI)
Binding site88FAD (UniProtKB | ChEBI)
Binding site156FAD (UniProtKB | ChEBI)
Binding site172FAD (UniProtKB | ChEBI)
Binding site335FAD (UniProtKB | ChEBI)
Binding site348FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionsqualene monooxygenase activity
Biological Processsterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Squalene epoxidase 5
  • EC number
  • Short names
    AtSQE5
  • Alternative names
    • Squalene monooxygenase 1,1 (SE 1,1)

Gene names

    • Name
      SQE5
    • Synonyms
      SQP1,1
    • ORF names
      K12G2.2
    • Ordered locus names
      At5g24150

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    O65404

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane3-23Helical
Transmembrane45-65Helical
Transmembrane446-466Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002098411-516Squalene epoxidase 5

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in seedlings, leaves, stems and inflorescences. Detected in siliques.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the squalene monooxygenase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete

This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.

O65404-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    516
  • Mass (Da)
    56,606
  • Last updated
    2000-12-01 v2
  • MD5 Checksum
    14975343D6E0261FC09A8F41E4F7EA37
MAFTNVCLWTLLAFMLTWTVFYVTNRGKKATQLADAVVEEREDGATDVIIVGAGVGGSALAYALAKDGRRVHVIERDLREPERIMGEFMQPGGRLMLSKLGLEDCLEGIDAQKATGMTVYKDGKEAVASFPVDNNNFPFDPSARSFHNGRFVQRLRQKASSLPNVRLEEGTVKSLIEEKGVIKGVTYKNSAGEETTALAPLTVVCDGCYSNLRRSLNDNNAEVLSYQVGFISKNCQLEEPEKLKLIMSKPSFTMLYQISSTDVRCVFEVLPNNIPSISNGEMATFVKNTIAPQVPLKLRKIFLKGIDEGEHIKAMPTKKMTATLSEKKGVILLGDAFNMRHPAIASGMMVLLSDILILRRLLQPLSNLGNAQKISQVIKSFYDIRKPMSATVNTLGNAFSQVLVASTDEAKEAMRQGCYDYLSSGGFRTSGMMALLGGMNPRPISLIYHLCAITLSSIGHLLSPFPSPLRIWHSLRLFGLAMKMLVPHLKAEGVSQMLFPVNAAAYSKSYMAATAL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F4KFQ9F4KFQ9_ARATHSQP1490

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB016883
EMBL· GenBank· DDBJ
BAB08406.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
AED93262.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ005930
EMBL· GenBank· DDBJ
CAA06772.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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