O62805 · O62805_TURTR
- ProteinSodium/potassium/calcium exchanger 1
- GeneNCKXr
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1014 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Calcium, potassium:sodium antiporter that transports 1 Ca2+ and 1 K+ in exchange for 4 Na+. Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation.
Catalytic activity
- Ca2+(out) + K+(out) + 4 Na+(in) = Ca2+(in) + K+(in) + 4 Na+(out)Ca2+ (out)CHEBI:29108
+ K+ (out)CHEBI:29103+ 4 Na+ (in)CHEBI:29101= Ca2+ (in)CHEBI:29108+ K+ (in)CHEBI:29103+ 4 Na+ (out)CHEBI:29101
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | calcium channel activity | |
Molecular Function | calcium, potassium:sodium antiporter activity | |
Biological Process | intracellular calcium ion homeostasis | |
Biological Process | visual perception |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSodium/potassium/calcium exchanger 1
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Whippomorpha > Cetacea > Odontoceti > Delphinidae > Tursiops
Accessions
- Primary accessionO62805
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 21-41 | Helical | ||||
Sequence: HWRRLLFLLGMLIMGSTYQYL | ||||||
Transmembrane | 450-469 | Helical | ||||
Sequence: WVVLHIFGMLYVFVALAIVC | ||||||
Transmembrane | 490-514 | Helical | ||||
Sequence: VAGATFMAAGGSAPELFTSLIGIFI | ||||||
Transmembrane | 520-542 | Helical | ||||
Sequence: GIGTIVGSAVFNILFVIGTCALF | ||||||
Transmembrane | 554-573 | Helical | ||||
Sequence: LFRDITFYILDLMMLILFFL | ||||||
Transmembrane | 579-598 | Helical | ||||
Sequence: WWESLLLLLAYALYVFTMKW | ||||||
Transmembrane | 852-875 | Helical | ||||
Sequence: FVITFLGSIMWIAMFSYLMVWWAH | ||||||
Transmembrane | 887-909 | Helical | ||||
Sequence: IMGLTILAAGTSIPDLITSVIVA | ||||||
Transmembrane | 954-977 | Helical | ||||
Sequence: NGLFCAIVLLFLMLLFVISSIALC | ||||||
Transmembrane | 984-1003 | Helical | ||||
Sequence: ILGFTMFLLYFVFLIISVML |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 96-114 | Polar residues | ||||
Sequence: TVGRDGTTPGVTMENTPSI | ||||||
Region | 96-197 | Disordered | ||||
Sequence: TVGRDGTTPGVTMENTPSIPRRIANVIPATPKSSDSPAAARTEKVKEDTPATPSGALNHYPPTSGRPVVNNYTPATRRGEVKSYRPTQARGKVRKYTPSPLG | ||||||
Compositional bias | 151-166 | Polar residues | ||||
Sequence: ALNHYPPTSGRPVVNN | ||||||
Region | 289-309 | Disordered | ||||
Sequence: RVDNNSSTNHRGLVGKNSLTT | ||||||
Region | 398-429 | Disordered | ||||
Sequence: VPVSSTDPSPSLTTAGMPETPSPSVLPSGQPD | ||||||
Compositional bias | 401-424 | Polar residues | ||||
Sequence: SSTDPSPSLTTAGMPETPSPSVLP | ||||||
Domain | 455-596 | Sodium/calcium exchanger membrane region | ||||
Sequence: IFGMLYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGIFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDITFYILDLMMLILFFLDSLIVWWESLLLLLAYALYVFTM | ||||||
Region | 626-816 | Disordered | ||||
Sequence: KGDVAEAESTGERTDNEVKTPGEGENGEQSGGEAQPEGEGEEKGENESEGDIQAERKGENESEGDIQAERKGDDEGEGEIQAGEDGEMKGDEGDLQAERKGDDEGEGEIQAGEDGEMKGDDGETGEQDLIADNQDDAKEDEKGIDGEEEGDGGESEDEEEEEEEGEEEEEQEEEEEEQEEEEEEEPLSLEW | ||||||
Compositional bias | 630-647 | Basic and acidic residues | ||||
Sequence: AEAESTGERTDNEVKTPG | ||||||
Compositional bias | 661-765 | Basic and acidic residues | ||||
Sequence: PEGEGEEKGENESEGDIQAERKGENESEGDIQAERKGDDEGEGEIQAGEDGEMKGDEGDLQAERKGDDEGEGEIQAGEDGEMKGDDGETGEQDLIADNQDDAKED | ||||||
Compositional bias | 766-813 | Acidic residues | ||||
Sequence: EKGIDGEEEGDGGESEDEEEEEEEGEEEEEQEEEEEEQEEEEEEEPLS | ||||||
Domain | 853-1001 | Sodium/calcium exchanger membrane region | ||||
Sequence: VITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWMLFSFINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIALCKWRMNKILGFTMFLLYFVFLIISV |
Sequence similarities
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,014
- Mass (Da)111,399
- Last updated1998-08-01 v1
- ChecksumA05A60493662D9D9
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 96-114 | Polar residues | ||||
Sequence: TVGRDGTTPGVTMENTPSI | ||||||
Compositional bias | 151-166 | Polar residues | ||||
Sequence: ALNHYPPTSGRPVVNN | ||||||
Compositional bias | 401-424 | Polar residues | ||||
Sequence: SSTDPSPSLTTAGMPETPSPSVLP | ||||||
Compositional bias | 630-647 | Basic and acidic residues | ||||
Sequence: AEAESTGERTDNEVKTPG | ||||||
Compositional bias | 661-765 | Basic and acidic residues | ||||
Sequence: PEGEGEEKGENESEGDIQAERKGENESEGDIQAERKGDDEGEGEIQAGEDGEMKGDEGDLQAERKGDDEGEGEIQAGEDGEMKGDDGETGEQDLIADNQDDAKED | ||||||
Compositional bias | 766-813 | Acidic residues | ||||
Sequence: EKGIDGEEEGDGGESEDEEEEEEEGEEEEEQEEEEEEQEEEEEEEPLS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF059031 EMBL· GenBank· DDBJ | AAC18119.1 EMBL· GenBank· DDBJ | mRNA |