O62805 · O62805_TURTR

Function

function

Calcium, potassium:sodium antiporter that transports 1 Ca2+ and 1 K+ in exchange for 4 Na+. Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functioncalcium channel activity
Molecular Functioncalcium, potassium:sodium antiporter activity
Biological Processintracellular calcium ion homeostasis
Biological Processvisual perception

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sodium/potassium/calcium exchanger 1
  • Alternative names
    • Na(+)/K(+)/Ca(2+)-exchange protein 1
    • Retinal rod Na-Ca+K exchanger
    • Solute carrier family 24 member 1

Gene names

    • Name
      NCKXr
    • Synonyms
      SLC24A1

Organism names

Accessions

  • Primary accession
    O62805

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-41Helical
Transmembrane450-469Helical
Transmembrane490-514Helical
Transmembrane520-542Helical
Transmembrane554-573Helical
Transmembrane579-598Helical
Transmembrane852-875Helical
Transmembrane887-909Helical
Transmembrane954-977Helical
Transmembrane984-1003Helical

Keywords

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias96-114Polar residues
Region96-197Disordered
Compositional bias151-166Polar residues
Region289-309Disordered
Region398-429Disordered
Compositional bias401-424Polar residues
Domain455-596Sodium/calcium exchanger membrane region
Region626-816Disordered
Compositional bias630-647Basic and acidic residues
Compositional bias661-765Basic and acidic residues
Compositional bias766-813Acidic residues
Domain853-1001Sodium/calcium exchanger membrane region

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,014
  • Mass (Da)
    111,399
  • Last updated
    1998-08-01 v1
  • Checksum
    A05A60493662D9D9
MGKLIRMGVQERRLLWPKRLHWRRLLFLLGMLIMGSTYQYLRSPRGLPSLCAAVSSQHPVKLARRDLSNNEMMMVSSDPPKSSPEMEVETWAPQATVGRDGTTPGVTMENTPSIPRRIANVIPATPKSSDSPAAARTEKVKEDTPATPSGALNHYPPTSGRPVVNNYTPATRRGEVKSYRPTQARGKVRKYTPSPLGRMVNSYAPSTFMTMTRSHGITPRATVKDSEIMTTNKILETNPSKRVLGETTPTPLKGVTDNVLPFLINDLETDILTSPRNVAEGKTLTTTRRVDNNSSTNHRGLVGKNSLTTPQGTVLEHTAATSEGQVAVSITTETKASTAAWKARNPSSRTSAPTVGISSATFWGLVKNPSPAPTTPATPRVRASPTTQVHHCVVVEPVPVSSTDPSPSLTTAGMPETPSPSVLPSGQPDLHPKAEYPRDLFSVKERRQGWVVLHIFGMLYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGIFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDITFYILDLMMLILFFLDSLIVWWESLLLLLAYALYVFTMKWNKQLELWVKKQLSRRPVPKVMALGDLSKGDVAEAESTGERTDNEVKTPGEGENGEQSGGEAQPEGEGEEKGENESEGDIQAERKGENESEGDIQAERKGDDEGEGEIQAGEDGEMKGDEGDLQAERKGDDEGEGEIQAGEDGEMKGDDGETGEQDLIADNQDDAKEDEKGIDGEEEGDGGESEDEEEEEEEGEEEEEQEEEEEEQEEEEEEEPLSLEWPETRQKQAIYLFLLPIVFPLWLTVPDVRRLEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWMLFSFINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIALCKWRMNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias96-114Polar residues
Compositional bias151-166Polar residues
Compositional bias401-424Polar residues
Compositional bias630-647Basic and acidic residues
Compositional bias661-765Basic and acidic residues
Compositional bias766-813Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF059031
EMBL· GenBank· DDBJ
AAC18119.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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