O62728 · LIF_NEOVI

Function

function

LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functioncytokine activity
Molecular Functiongrowth factor activity
Molecular Functionleukemia inhibitory factor receptor binding
Biological Processimmune response
Biological Processleukemia inhibitory factor signaling pathway
Biological Processpositive regulation of cell population proliferation
Biological Processregulation of cell communication
Biological Processregulation of cell differentiation
Biological Processregulation of signaling

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Leukemia inhibitory factor
  • Short names
    LIF

Gene names

    • Name
      LIF

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Musteloidea > Mustelidae > Mustelinae > Neogale

Accessions

  • Primary accession
    O62728

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_000001771723-202Leukemia inhibitory factor
Glycosylation31N-linked (GlcNAc...) asparagine
Disulfide bond34↔156
Disulfide bond40↔153
Glycosylation56N-linked (GlcNAc...) asparagine
Disulfide bond82↔185
Glycosylation85N-linked (GlcNAc...) asparagine
Glycosylation95N-linked (GlcNAc...) asparagine
Glycosylation118N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Structure

Family & Domains

Sequence similarities

Belongs to the LIF/OSM family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    202
  • Mass (Da)
    22,114
  • Last updated
    1998-08-01 v1
  • Checksum
    B54DCD53F8138AFB
MKVLAAGVVPLLLVLHWKHGAGTPLPITPVNATCATRHPCHSNLMNQIRNQLAHVNGSANALFILYYTAQGEPFPNNLDKLCGPNVTDFPPFHRNGTEKTRLVELYRIIAYLGASLGNITRDQKVLNPNALSLHSKLKATADILRGLLSNVLCRLCNKYHVAHVDVAYGPDTSGKDVFQKKKLGCQLLGKYKQVIAVVAQAF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF048827
EMBL· GenBank· DDBJ
AAC05638.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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