O62709 · EDNRB_HORSE

  • Protein
    Endothelin receptor type B
  • Gene
    EDNRB
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionendothelin receptor activity
Biological Processcalcium-mediated signaling
Biological Processdevelopmental pigmentation
Biological Processendothelin receptor signaling pathway
Biological Processenteric nervous system development
Biological Processregulation of blood pressure
Biological Processvasoconstriction

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Endothelin receptor type B
  • Short names
    ET-B; ET-BR
  • Alternative names
    • Endothelin receptor non-selective type

Gene names

    • Name
      EDNRB

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus

Accessions

  • Primary accession
    O62709
  • Secondary accessions
    • O77508

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Note: internalized after activation by endothelins.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain27-102Extracellular
Transmembrane103-127Helical; Name=1
Topological domain128-138Cytoplasmic
Transmembrane139-164Helical; Name=2
Topological domain165-176Extracellular
Transmembrane177-198Helical; Name=3
Topological domain199-219Cytoplasmic
Transmembrane220-244Helical; Name=4
Topological domain245-272Extracellular
Transmembrane273-297Helical; Name=5
Topological domain298-325Cytoplasmic
Transmembrane326-351Helical; Name=6
Topological domain352-363Extracellular
Transmembrane364-390Helical; Name=7
Topological domain391-443Cytoplasmic

Keywords

Phenotypes & Variants

Involvement in disease

  • Defects in EDNRB are a cause of overo lethal white syndrome (OLWS) also known as lethal white foal syndrome (LWFS). It is an inherited syndrome of foals born to American paint horse parents of the overo coat-pattern lineage. Affected foals are totally or almost totally white and die within days from complications due to intestinal aganglionosis

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant126in OLWS

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond, modified residue, lipidation.

TypeIDPosition(s)Description
Signal1-26
ChainPRO_000001272827-443Endothelin receptor type B
Glycosylation60N-linked (GlcNAc...) asparagine
Disulfide bond175↔256
Modified residue306Phosphoserine
Lipidation403S-palmitoyl cysteine
Lipidation404S-palmitoyl cysteine
Lipidation406S-palmitoyl cysteine
Modified residue420Phosphoserine
Modified residue440Phosphotyrosine
Modified residue441Phosphoserine
Modified residue442Phosphoserine
Modified residue443Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias51-66Polar residues
Region51-89Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    443
  • Mass (Da)
    50,006
  • Last updated
    2000-05-30 v2
  • Checksum
    74381DDFCF9A9AF4
MQPLPTLCGRVLVALILACGVAGVQGEERRFPPARATPPLLGFEEIMTPPTKTSWPTGSNASVPRLSAPPQMPKAGRTAGAQRRTLPPPPCERTIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAVGFDMITADYKGSYLRICLLHPTQKTAFMQFYKNAKDWWLFSFYFCLPLAITAFFYTLETCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKHTLYDQNDPHRCELLSFLLVLEYIGINMASLNSCINPIALYLVSKRFKNCFKWCLCCWCQSFEEKQSLEDKQSCLKFKANDHGYDNFRSSNKYSSS

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict11in Ref. 2; AAC23486
Sequence conflict43-44in Ref. 2; AAC23486
Compositional bias51-66Polar residues
Sequence conflict64-66in Ref. 2; AAC23486
Sequence conflict79in Ref. 2; AAC23486
Sequence conflict92in Ref. 2; AAC23486
Sequence conflict297in Ref. 2; AAC23486
Sequence conflict369in Ref. 2; AAC23486
Sequence conflict400in Ref. 2; AAC23486

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF019072
EMBL· GenBank· DDBJ
AAC25983.1
EMBL· GenBank· DDBJ
mRNA
AF038900
EMBL· GenBank· DDBJ
AAC23486.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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