O62657 · SDF1_FELCA

Function

function

Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells.

Features

Showing features for binding site, site.

193102030405060708090MDAKVVAVLALVLAALCLSDGKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNKRFKM
Type
IDPosition(s)Description
Binding site41-51heparin (UniProtKB | ChEBI)
Site45Important for integrin interaction and activation
Site46Important for dimer formation
Site48Important for integrin interaction and activation
Binding site62heparin (UniProtKB | ChEBI)
Site64Important for integrin interaction and activation
Binding site69heparin (UniProtKB | ChEBI)
Binding site85heparin (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentexternal side of plasma membrane
Cellular Componentextracellular space
Molecular Functionchemokine activity
Molecular Functionchemokine receptor binding
Molecular FunctionCXCR chemokine receptor binding
Molecular Functiongrowth factor activity
Molecular Functionintegrin binding
Biological Processaxon guidance
Biological Processcell chemotaxis
Biological Processchemokine-mediated signaling pathway
Biological Processdefense response
Biological Processimmune response
Biological Processinduction of positive chemotaxis
Biological Processintegrin activation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Stromal cell-derived factor 1
  • Short names
    SDF-1
  • Alternative names
    • C-X-C motif chemokine 12

Gene names

    • Name
      CXCL12
    • Synonyms
      SDF1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Feliformia > Felidae > Felinae > Felis

Accessions

  • Primary accession
    O62657
  • Secondary accessions
    • Q54AJ3

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-21
ChainPRO_000000510822-93Stromal cell-derived factor 1
Disulfide bond30↔55
Disulfide bond32↔71

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Monomer or homodimer; in equilibrium. Dimer formation is induced by non acidic pH and the presence of multivalent anions, and by binding to CXCR4 or heparin. Monomeric form is required for full chemotactic activity and resistance to ischemia/reperfusion injury, whereas the dimeric form acts as a partial agonist of CXCR4, stimulating Ca2+ mobilization but with no chemotactic activity and instead acts as a selective antagonist that blocks chemotaxis induced by the monomeric form. Interacts with the N-terminus of ACKR3. Interacts with integrin subunit ITGB3 (via the allosteric site (site 2)). Interacts with TNFAIP6 (via Link domain).

Protein-protein interaction databases

Family & Domains

Features

Showing features for motif, region.

Type
IDPosition(s)Description
Motif22-23Receptor activation motif
Region29-33Receptor and heparin binding
Region39-41Receptor binding
Region48-50Receptor binding
Region60-70Receptor binding

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

O62657-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    Beta
  • Synonyms
    SDF-1b
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    93
  • Mass (Da)
    10,581
  • Last updated
    1998-08-01 v1
  • Checksum
    44FC763711E9BE37
MDAKVVAVLALVLAALCLSDGKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNKRFKM

O62657-2

  • Name
    Alpha
  • Synonyms
    SDF-1a
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F5Y290A0A5F5Y290_FELCACXCL12143
A0A2I2U9C3A0A2I2U9C3_FELCACXCL12119

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_00105590-93in isoform Alpha

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB011965
EMBL· GenBank· DDBJ
BAA28601.1
EMBL· GenBank· DDBJ
mRNA
AB011966
EMBL· GenBank· DDBJ
BAA28602.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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