O62619 · KPYK_DROME
- ProteinPyruvate kinase
- GenePyk
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids533 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
Catalytic activity
- ATP + pyruvate = ADP + H+ + phosphoenolpyruvate
Cofactor
Protein has several cofactor binding sites:
Pathway
Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 76 | substrate | ||||
Sequence: R | ||||||
Binding site | 78 | K+ (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 78-81 | ATP (UniProtKB | ChEBI) | ||||
Sequence: NFSH | ||||||
Binding site | 80 | K+ (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 116 | K+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 117 | K+ (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 123 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 210 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Site | 273 | Transition state stabilizer | ||||
Sequence: K | ||||||
Binding site | 275 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 298 | substrate | ||||
Sequence: G | ||||||
Binding site | 299 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 299 | substrate | ||||
Sequence: D | ||||||
Binding site | 331 | substrate | ||||
Sequence: T |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | P granule | |
Molecular Function | ATP binding | |
Molecular Function | kinase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | potassium ion binding | |
Molecular Function | pyruvate kinase activity | |
Biological Process | canonical glycolysis | |
Biological Process | glucose homeostasis | |
Biological Process | glycolytic process | |
Biological Process | pyruvate biosynthetic process | |
Biological Process | pyruvate metabolic process | |
Biological Process | response to sucrose |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePyruvate kinase
- EC number
- Short namesPK
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionO62619
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000112099 | 1-533 | Pyruvate kinase | |||
Sequence: MVNVTIYDEAPQLKPNEVPQNMAAGADTQLEHMCRLQFDSPVPHVRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSAKLGYEHPVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKEFLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAGTIDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLIYKEPGLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGSGFTNTIRIVTVE |
Proteomic databases
Expression
Tissue specificity
In adults expressed predominantly in the thorax.
Developmental stage
Low levels in larvae and pupae, but increases in young adults, becoming relatively stable in two-day-old flies.
Gene expression databases
Structure
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
O62619-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameA
- Length533
- Mass (Da)57,440
- Last updated2003-01-27 v2
- ChecksumA8376B72F040EEDB
O62619-2
- NameB
- Differences from canonical
- 1-21: Missing
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_002885 | 1-21 | in isoform B | |||
Sequence: Missing | ||||||
Sequence conflict | 180 | in Ref. 1; AAC16244/AAC15808 | ||||
Sequence: D → N | ||||||
Sequence conflict | 271 | in Ref. 4; AAO24935 | ||||
Sequence: I → F | ||||||
Sequence conflict | 397 | in Ref. 1; AAC16244/AAC15808 | ||||
Sequence: L → F |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF062478 EMBL· GenBank· DDBJ | AAC16244.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF061507 EMBL· GenBank· DDBJ | AAC15808.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014297 EMBL· GenBank· DDBJ | AAF55979.3 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | AAN14373.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY118442 EMBL· GenBank· DDBJ | AAM48471.1 EMBL· GenBank· DDBJ | mRNA | ||
BT003180 EMBL· GenBank· DDBJ | AAO24935.1 EMBL· GenBank· DDBJ | mRNA | ||
BT082045 EMBL· GenBank· DDBJ | ACO95723.1 EMBL· GenBank· DDBJ | mRNA |