O62585 · GLYC_ENCCU

Function

function

Interconversion of serine and glycine.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Biological Processglycine biosynthetic process from serine
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase, cytosolic
  • EC number
  • Short names
    SHMT
  • Alternative names
    • Glycine hydroxymethyltransferase
    • Serine methylase

Gene names

    • Name
      SHMT-1
    • Ordered locus names
      ECU01_0190
    • Name
      SHMT-2
    • Ordered locus names
      ECU01_1420

Organism names

Accessions

  • Primary accession
    O62585
  • Secondary accessions
    • Q8SQH9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001135091-460Serine hydroxymethyltransferase, cytosolic
Modified residue244N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the SHMT family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    460
  • Mass (Da)
    50,181
  • Last updated
    2004-08-31 v2
  • Checksum
    E322D7A78AC0DAAE
MTDAREKGFWTGPLEMADPELHALICGEVERQKKTINLIASENYAHQSAMEACGSVLTNKYSEGRVGERYYGGTHWVDRIELLCQKRALELFGLDPDVWGVNVQPYSGSPANFAIYTAVVPPGGRIMGLDLPSGGHLTHGYKTKTRKISASSVYFDSRPYTVGSNGLIDYEGLEKTFTDFLPHILICGYSAYSRDIDYKRLQSIAGRNGAFLFADISHISPLVASGLMNSPFEHCDIVMTTTQKGLRGPRGALIFYRRAVTKNGETVDLDARINFAVFPMLQGGPHNHTIAGIASALLHAGTPEFAEYTRRVVENSRELCSRLQSLGLDILTGGTDNHMLLVDLRSTGVDGAAVEHMCDALGISLNRNAIVGNSSPLSPSGIRVGTYAVTARGFGPEEMREVGDIIGGVVKLCREMTGGRKMSKADLHRVTSDARVMGSEQVLVLRRRVCALAEAYPIYE

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict98in Ref. 1; CAA06649
Sequence conflict102in Ref. 1; CAA06649

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ005644
EMBL· GenBank· DDBJ
CAA06649.1
EMBL· GenBank· DDBJ
Genomic DNA
AL391737
EMBL· GenBank· DDBJ
CAD24889.1
EMBL· GenBank· DDBJ
Genomic DNA
AL391737
EMBL· GenBank· DDBJ
CAD25015.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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