O61967 · LAP1_CAEEL
- ProteinProtein lap1
- Genelet-413
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids699 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells. Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells. Required for correct localization of ifb-2 intermediate filaments in the terminal web. Required for dlg-1 lateral localization (PubMed:18411252).
With dlg-1, cooperatively regulates ajm-1 localization to apical junctions (PubMed:11715019).
With dlg-1, cooperatively regulates ajm-1 localization to apical junctions (PubMed:11715019).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | basolateral plasma membrane | |
Biological Process | actin filament-based process | |
Biological Process | adherens junction assembly | |
Biological Process | cell adhesion | |
Biological Process | cell-cell junction assembly | |
Biological Process | embryo development ending in birth or egg hatching | |
Biological Process | embryonic digestive tract morphogenesis | |
Biological Process | establishment or maintenance of cell polarity | |
Biological Process | maintenance of epithelial cell apical/basal polarity | |
Biological Process | protein transport | |
Biological Process | regulation of intermediate filament polymerization or depolymerization |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein lap1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionO61967
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Basolateral cell membrane ; Peripheral membrane protein
Note: Basolateral membrane of epithelial cells.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Worms display a severely affected epithelial integrity, leading to abnormal morphogenesis of the pharynx, intestine and embryo.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 305 | Abolishes membrane localization. | ||||
Sequence: P → L |
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000188305 | 1-699 | Protein lap1 | |||
Sequence: MPAFFCLPMACQRQVDSIDRSQSNLQAIPSDIFRFRKLEDLNLTMNNIKELDHRLFSLRHLRILDVSDNELAVLPAEIGNLTQLIELNLNRNSIAKLPDTMQNCKLLTTLNLSSNPFTRLPETICECSSITILSLNETSLTLLPSNIGSLTNLRVLEARDNLLRTIPLSIVELRKLEELDLGQNELEALPAEIGKLTSLREFYVDINSLTSLPDSISGCRMLDQLDVSENQIIRLPENLGRMPNLTDLNISINEIIELPSSFGELKRLQMLKADRNSLHNLTSEIGKCQSLTELYLGQNFLTDLPDTIGDLRQLTTLNVDCNNLSDIPDTIGNCKSLTVLSLRQNILTELPMTIGKCENLTVLDVASNKLPHLPFTVKVLYKLQALWLSENQTQSILKLSETRDDRKGIKVVTCYLLPQVDAIDGEGRSGSAQHNTDRGAFLGGPKVHFHDQADTTFEENKEAEIHLGNFERHNTPHPKTPKHKKGSIDGHMLPHEIDQPRQLSLVSNHRTSTSSFGESSNSINRDLADIRAQNGVREATLSPEREERMATSLSSLSNLAAGTQNMHTIRIQKDDTGKLGLSFAGGTSNDPAPNSNGDSGLFVTKVTPGSAAYRCGLREGDKLIRANDVNMINASQDNAMEAIKKRETVELVVLRRSPSPVSRTSEPSLNGSSHQLNHFDAGSPDSTMFVTSSTPVYAS |
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for repeat, domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 37-59 | LRR 1 | ||||
Sequence: KLEDLNLTMNNIKELDHRLFSLR | ||||||
Repeat | 60-81 | LRR 2 | ||||
Sequence: HLRILDVSDNELAVLPAEIGNL | ||||||
Repeat | 83-104 | LRR 3 | ||||
Sequence: QLIELNLNRNSIAKLPDTMQNC | ||||||
Repeat | 106-127 | LRR 4 | ||||
Sequence: LLTTLNLSSNPFTRLPETICEC | ||||||
Repeat | 129-150 | LRR 5 | ||||
Sequence: SITILSLNETSLTLLPSNIGSL | ||||||
Repeat | 152-174 | LRR 6 | ||||
Sequence: NLRVLEARDNLLRTIPLSIVELR | ||||||
Repeat | 175-196 | LRR 7 | ||||
Sequence: KLEELDLGQNELEALPAEIGKL | ||||||
Repeat | 198-219 | LRR 8 | ||||
Sequence: SLREFYVDINSLTSLPDSISGC | ||||||
Repeat | 221-242 | LRR 9 | ||||
Sequence: MLDQLDVSENQIIRLPENLGRM | ||||||
Repeat | 244-265 | LRR 10 | ||||
Sequence: NLTDLNISINEIIELPSSFGEL | ||||||
Repeat | 267-288 | LRR 11 | ||||
Sequence: RLQMLKADRNSLHNLTSEIGKC | ||||||
Repeat | 290-311 | LRR 12 | ||||
Sequence: SLTELYLGQNFLTDLPDTIGDL | ||||||
Repeat | 313-334 | LRR 13 | ||||
Sequence: QLTTLNVDCNNLSDIPDTIGNC | ||||||
Repeat | 336-357 | LRR 14 | ||||
Sequence: SLTVLSLRQNILTELPMTIGKC | ||||||
Repeat | 359-380 | LRR 15 | ||||
Sequence: NLTVLDVASNKLPHLPFTVKVL | ||||||
Repeat | 382-403 | LRR 16 | ||||
Sequence: KLQALWLSENQTQSILKLSETR | ||||||
Domain | 584-665 | PDZ | ||||
Sequence: AGGTSNDPAPNSNGDSGLFVTKVTPGSAAYRCGLREGDKLIRANDVNMINASQDNAMEAIKKRETVELVVLRRSPSPVSRTS | ||||||
Region | 656-699 | Disordered | ||||
Sequence: RSPSPVSRTSEPSLNGSSHQLNHFDAGSPDSTMFVTSSTPVYAS | ||||||
Compositional bias | 658-699 | Polar residues | ||||
Sequence: PSPVSRTSEPSLNGSSHQLNHFDAGSPDSTMFVTSSTPVYAS |
Sequence similarities
Belongs to the LAP (LRR and PDZ) protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
O61967-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Nameb
- Length699
- Mass (Da)77,350
- Last updated2005-09-27 v3
- Checksum2CE6478B5039F2DE
O61967-2
- Namea
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A5K1I804 | A0A5K1I804_CAEEL | let-413 | 682 | ||
A0A5K1I8A6 | A0A5K1I8A6_CAEEL | let-413 | 669 | ||
A0A5K1IC26 | A0A5K1IC26_CAEEL | let-413 | 706 | ||
A0A5K1IAV7 | A0A5K1IAV7_CAEEL | let-413 | 689 |
Features
Showing features for alternative sequence, compositional bias.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ276590 EMBL· GenBank· DDBJ | CAB91651.1 EMBL· GenBank· DDBJ | mRNA | ||
FO081227 EMBL· GenBank· DDBJ | CCD70053.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FO081227 EMBL· GenBank· DDBJ | CCD70054.1 EMBL· GenBank· DDBJ | Genomic DNA |