O61643 · INHB_DROME
- ProteinInhibin beta chain
- GeneActbeta
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids946 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Controls several aspects of neuronal morphogenesis; essential for optic lobe development, EcR-B1 expression in larval brains, mushroom body remodeling, dorsal neuron morphogenesis and motoneuron axon guidance. Ligands Actbeta and daw act redundantly through the Activin receptor Babo and its transcriptional mediator Smad2 (Smox), to regulate neuroblast numbers and proliferation rates in the developing larval brain.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 585-586 | Cleavage; by tok and tld | ||||
Sequence: ND |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Molecular Function | cytokine activity | |
Molecular Function | growth factor activity | |
Biological Process | activin receptor signaling pathway | |
Biological Process | glucose homeostasis | |
Biological Process | mushroom body development | |
Biological Process | positive regulation of glycogen catabolic process | |
Biological Process | positive regulation of imaginal disc growth | |
Biological Process | positive regulation of neuroblast proliferation | |
Biological Process | R8 cell fate specification | |
Biological Process | regulation of imaginal disc-derived wing size | |
Biological Process | regulation of synapse structure or activity | |
Biological Process | response to glucose |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInhibin beta chain
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionO61643
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Development of larvae with small brains and aberrant photoreceptor axon targeting.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 583-586 | Abolishes cleavage by tok. | ||||
Sequence: YFND → AAAA |
PTM/Processing
Features
Showing features for propeptide, signal, glycosylation, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Propeptide | PRO_0000033742 | ?-830 | ||||
Sequence: MRFAFDSNHSQSGAPFKGSRCFFNCQCICCRQGCCVVVVKCCCCFNLNCCNSLGSRKSFPQPAAMRKKVADLEVLRVSRFVAVILVLARWVTAVATLLTSCILLDIFSVPGQSGVADRSQASSRTVHVSVPTTPNETPSSTSETKLKLLYGYTSYDINNDQQVKSNNLCRVLCKSRNRKRQRRRRRRRNHRRRRHRYTKRLHHLMQDNMSGFEQRLNFSDAKCQSLETNYGTNYDLVQGGKLFSQSERSLLVSPLREIEAPWPAIHGSMRNCSKIKRNRANLIWLLIGLVWFEVKLINCNGISSSNYYASNLESHKGCTLCHESGKPNIYTDKDNPHTDYNIYNKYHSNNNFNKKTNQPHNNIAPSDEVRLESIKRQILTKLGLSHKPNVSHPLPKQFIWETIYRVDGGRMIPNNAFGSSGKNLDQKTIKLRAFASPGSHLFNGRGGRTDQRSERDPSHHKYRSPFDFTFNISKNNVYGKVLRNRSLERIDKKNSFLNGWTENRQLKINSQIASMPIELKSHHNSSPKELKSGAVRKVNGINGTQMNENALKKSTYPIDINHSIDNKTHTGKNGEMSHNDYEYFNDYSVQTHDKNRYHEGRSSIGYQPAIHNIEYENQKGHHESFADDHENIDHEDFFGNTQEIITFAEEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVFQLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSHEKLRLLIDCTGCGGRYSLHLFQTSKLRGNSSDYLSTNPNRPFLVLHTESSRTRRV | ||||||
Signal | 1-? | |||||
Glycosylation | 208 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 217 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 271 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 389 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 471 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 484 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 542 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 561 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 566 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 732 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 804 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Chain | PRO_0000033743 | 834-946 | Inhibin beta chain | |||
Sequence: AVDCGGALNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQTFHAHFIEEYRKMGLMNGMRPCCAPIKFSSMSLIYYGDDGIIKRDLPKMVVDECGCP | ||||||
Disulfide bond | 837↔846 | |||||
Sequence: CGGALNGQCC | ||||||
Disulfide bond | 845↔912 | |||||
Sequence: CCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQTFHAHFIEEYRKMGLMNGMRPCC | ||||||
Disulfide bond | 874↔943 | |||||
Sequence: CRGDCTGSFRTPDTFQTFHAHFIEEYRKMGLMNGMRPCCAPIKFSSMSLIYYGDDGIIKRDLPKMVVDEC | ||||||
Disulfide bond | 878↔945 | |||||
Sequence: CTGSFRTPDTFQTFHAHFIEEYRKMGLMNGMRPCCAPIKFSSMSLIYYGDDGIIKRDLPKMVVDECGC | ||||||
Disulfide bond | 911 | Interchain | ||||
Sequence: C |
Post-translational modification
Cleaved in vitro by metalloproteases tok and tld to produce a 30 kDa product.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed in larval brains.
Developmental stage
Expressed in embryonic, larval and adult stages.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 115-142 | Disordered | ||||
Sequence: VADRSQASSRTVHVSVPTTPNETPSSTS | ||||||
Region | 174-194 | Disordered | ||||
Sequence: KSRNRKRQRRRRRRRNHRRRR | ||||||
Region | 436-462 | Disordered | ||||
Sequence: SPGSHLFNGRGGRTDQRSERDPSHHKY | ||||||
Compositional bias | 447-462 | Basic and acidic residues | ||||
Sequence: GRTDQRSERDPSHHKY |
Sequence similarities
Belongs to the TGF-beta family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length946
- Mass (Da)108,792
- Last updated2003-01-27 v2
- Checksum7CECD6E73EAA306B
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 275 | in Ref. 4; AAL51005 | ||||
Sequence: I → V | ||||||
Compositional bias | 447-462 | Basic and acidic residues | ||||
Sequence: GRTDQRSERDPSHHKY | ||||||
Sequence conflict | 517 | in Ref. 4; AAL51005 | ||||
Sequence: I → T |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014135 EMBL· GenBank· DDBJ | AAF59386.3 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY121686 EMBL· GenBank· DDBJ | AAM52013.1 EMBL· GenBank· DDBJ | mRNA | ||
AF454392 EMBL· GenBank· DDBJ | AAL51005.1 EMBL· GenBank· DDBJ | mRNA | ||
AF054822 EMBL· GenBank· DDBJ | AAC39083.1 EMBL· GenBank· DDBJ | Genomic DNA |