O61493 · HOOK_DROVI

Function

function

Involved in endocytic trafficking by stabilizing organelles of the endocytic pathway. Probably acts as a cytoskeletal linker protein required to tether endosome vesicles to the cytoskeleton. Involved in modulation of endocytosis at stages required for down-regulation of membrane proteins that control synapse size. Not involved in synaptic vesicle recycling. Required in R7 cells for boss endocytosis into multivesicular bodies (MVBs). Has a role in regulating adult longevity.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcentrosome
Cellular Componentendosome
Cellular Componentmicrotubule
Cellular Componentsynapse
Molecular Functiondynein light intermediate chain binding
Molecular Functionmicrotubule binding
Biological Processcytoplasmic microtubule organization
Biological Processcytoskeleton-dependent intracellular transport
Biological Processendocytosis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein hook

Gene names

    • Name
      hook
    • Synonyms
      hk
    • ORF names
      GJ11581

Organism names

  • Taxonomic identifier
  • Strain
    • Tucson 15010-1051.87
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila

Accessions

  • Primary accession
    O61493
  • Secondary accessions
    • B4LS91

Proteomes

Subcellular Location

Endosome
Synapse
Note: Enriched at neuromuscular synapses, in both presynaptic and postsynaptic regions.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002192001-678Protein hook

Interaction

Subunit

Homodimer. Interacts with microtubules via its N-terminus.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain, coiled coil.

TypeIDPosition(s)Description
Region1-155Interaction with microtubules
Domain5-123Calponin-homology (CH)
Coiled coil135-435
Coiled coil479-589

Domain

The coiled coil domain mediates homodimerization.

Sequence similarities

Belongs to the hook family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    678
  • Mass (Da)
    77,199
  • Last updated
    1998-08-01 v1
  • Checksum
    1B8535E80F06C673
MSTQNGMYYSLLEWFKTLNLNAPHANAEELADGVALAQALNQFAPESFTNSWLSKIKSSAVGGNWRLRMSNLKKVVEGVYEYYSDVLNYTLQHDFVKPDVQAIAEKCDLSELERLLQLVLGCAVNCAKKQSYICEIMCLEEELQANIMRALQELESSTRQTTEGGVVSSLSRNSLSGMLDGNAKALEERDAMAQKCFETEKKMLLLIDEKTNLQQELHKLQLEFARLEHNTIGDDGVSLGPIQAGSVRYNELRRQLELVKEELLQSEGAREDLKIKAQQQETDLLHMQQRIDELMKSTAELTALKDEVDVLRESTDKLKVCEAQLETYKKKLEEYNDLKKHVKMLEERSADYVQQNAQFEEDAKRYANTKGQVELFKKEIQDLHAQLDNESSKNVKLEFDNKNLESKTLALQREKDNLLKERDNLREAFDELKCGQLSTNSGSLTGTTMSRELQPPAMMDKMQRLEAENKALREGQGGQTALAQLLDDANKRCEHLREQLKTANERILSLSHASQSDDPILKENEFSKQIKQLMELNEQKTLQIEESATQNSTMQCKITQLESTLATREQELMAYEVKYRKCIERAKEVIKNIDPRIASVMEANNLEKSVDVIEEESKTKMSGMEEQLMASAFYRLGVNAQRDAVDSKLALLMGSGQTFLARQRQSAPRKPLTTMKSK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF044926
EMBL· GenBank· DDBJ
AAC09301.1
EMBL· GenBank· DDBJ
Genomic DNA
CH940649
EMBL· GenBank· DDBJ
EDW63699.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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