O60902 · SHOX2_HUMAN
- ProteinShort stature homeobox protein 2
- GeneSHOX2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids331 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 140-199 | Homeobox | ||||
Sequence: QRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQE |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameShort stature homeobox protein 2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO60902
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 537 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000049292 | 1-331 | UniProt | Short stature homeobox protein 2 | |||
Sequence: MEELTAFVSKSFDQKVKEKKEAITYREVLESGPLRGAKEPTGCTEAGRDDRSSPAVRAAGGGGGGGGGGGGGGGGGGVGGGGAGGGAGGGRSPVRELDMGAAERSREPGSPRLTEVSPELKDRKEDAKGMEDEGQTKIKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQLHKGVLIGAASQFEACRVAPYVNVGALRMPFQQDSHCNVTPLSFQVQAQLQLDSAVAHAHHHLHPHLAAHAPYMMFPAPPFGLPLATLAADSASAASVVAAAAAAKTTSKNSSIADLRLKAKKHAAALGL | |||||||
Modified residue (large scale data) | 92 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in heart, skeletal muscle, liver, lung, bone marrow fibroblast, pancreas and placenta.
Developmental stage
Expressed during cranofacial development as well as in heart.
Gene expression databases
Organism-specific databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | O60902-3 | CASP6 P55212 | 3 | EBI-9092164, EBI-718729 | |
BINARY | O60902-3 | CCT5 P48643 | 3 | EBI-9092164, EBI-355710 | |
BINARY | O60902-3 | COQ8A Q8NI60 | 3 | EBI-9092164, EBI-745535 | |
BINARY | O60902-3 | FGFR3 P22607 | 3 | EBI-9092164, EBI-348399 | |
BINARY | O60902-3 | GRIN2C Q14957 | 3 | EBI-9092164, EBI-8285963 | |
BINARY | O60902-3 | GRN P28799 | 3 | EBI-9092164, EBI-747754 | |
BINARY | O60902-3 | KIF1B O60333-2 | 3 | EBI-9092164, EBI-10975473 | |
BINARY | O60902-3 | LAMP2 P13473-2 | 3 | EBI-9092164, EBI-21591415 | |
BINARY | O60902-3 | PIAS4 Q8N2W9 | 3 | EBI-9092164, EBI-473160 | |
BINARY | O60902-3 | PRPF40A O75400-2 | 3 | EBI-9092164, EBI-5280197 | |
BINARY | O60902-3 | RNF11 Q9Y3C5 | 3 | EBI-9092164, EBI-396669 | |
BINARY | O60902-3 | WFS1 O76024 | 3 | EBI-9092164, EBI-720609 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 27-140 | Disordered | ||||
Sequence: EVLESGPLRGAKEPTGCTEAGRDDRSSPAVRAAGGGGGGGGGGGGGGGGGGVGGGGAGGGAGGGRSPVRELDMGAAERSREPGSPRLTEVSPELKDRKEDAKGMEDEGQTKIKQ | ||||||
Compositional bias | 97-140 | Basic and acidic residues | ||||
Sequence: LDMGAAERSREPGSPRLTEVSPELKDRKEDAKGMEDEGQTKIKQ | ||||||
Motif | 313-326 | OAR | ||||
Sequence: SSIADLRLKAKKHA |
Sequence similarities
Belongs to the paired homeobox family. Bicoid subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
O60902-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsSHOX2A, SHOTA
- NoteMay be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
- Length331
- Mass (Da)34,953
- Last updated2007-04-17 v4
- Checksum06402B3955682252
O60902-2
- Name2
- SynonymsSHOX2B, SHOTB, OG12XB
- Differences from canonical
- 235-246: Missing
O60902-3
- Name3
- Differences from canonical
- 115-115: E → EGRRKPTKAEVQATLLLPGEAFRFL
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A087WVB7 | A0A087WVB7_HUMAN | SHOX2 | 146 |
Sequence caution
Features
Showing features for compositional bias, alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 97-140 | Basic and acidic residues | ||||
Sequence: LDMGAAERSREPGSPRLTEVSPELKDRKEDAKGMEDEGQTKIKQ | ||||||
Alternative sequence | VSP_024427 | 115 | in isoform 3 | |||
Sequence: E → EGRRKPTKAEVQATLLLPGEAFRFL | ||||||
Sequence conflict | 125 | in Ref. 1; CAA05341 | ||||
Sequence: E → D | ||||||
Alternative sequence | VSP_002288 | 235-246 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 244 | in Ref. 1; CAA05341 | ||||
Sequence: S → P | ||||||
Sequence conflict | 312 | in Ref. 1; CAA05341/CAA05342 | ||||
Sequence: N → D | ||||||
Sequence conflict | 325 | in Ref. 3; AAC39663 | ||||
Sequence: H → L |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ002367 EMBL· GenBank· DDBJ | CAA05341.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AJ002368 EMBL· GenBank· DDBJ | CAA05342.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
BC008829 EMBL· GenBank· DDBJ | AAH08829.1 EMBL· GenBank· DDBJ | mRNA | ||
AF022654 EMBL· GenBank· DDBJ | AAC39662.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AF023203 EMBL· GenBank· DDBJ | AAC39663.1 EMBL· GenBank· DDBJ | mRNA |