O60895 · RAMP2_HUMAN

  • Protein
    Receptor activity-modifying protein 2
  • Gene
    RAMP2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentadrenomedullin receptor complex
Cellular Componentcell surface
Cellular Componentclathrin-coated pit
Cellular Componentcytoplasm
Cellular Componentlysosome
Cellular Componentplasma membrane
Cellular Componentreceptor complex
Molecular Functionadrenomedullin binding
Molecular Functionadrenomedullin receptor activity
Molecular Functioncoreceptor activity
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processadherens junction assembly
Biological Processadrenomedullin receptor signaling pathway
Biological Processangiogenesis
Biological Processbasement membrane assembly
Biological Processbicellular tight junction assembly
Biological Processcalcium ion transport
Biological Processcellular response to hormone stimulus
Biological Processcellular response to vascular endothelial growth factor stimulus
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processheart development
Biological Processintracellular protein transport
Biological Processnegative regulation of endothelial cell apoptotic process
Biological Processnegative regulation of vascular permeability
Biological Processpositive regulation of angiogenesis
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of vasculogenesis
Biological Processprotein localization to plasma membrane
Biological Processprotein transport
Biological Processreceptor internalization
Biological Processregulation of blood pressure
Biological Processregulation of G protein-coupled receptor signaling pathway
Biological Processsprouting angiogenesis
Biological Processvascular associated smooth muscle cell development
Biological Processvasculogenesis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Receptor activity-modifying protein 2
  • Alternative names
    • Calcitonin-receptor-like receptor activity-modifying protein 2 (CRLR activity-modifying protein 2)

Gene names

    • Name
      RAMP2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    O60895
  • Secondary accessions
    • A7L9S6
    • K7EMD3
    • Q8N1F2

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain43-145Extracellular
Transmembrane146-166Helical
Topological domain167-175Cytoplasmic

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 168 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-42
ChainPRO_000003017243-175Receptor activity-modifying protein 2
Disulfide bond68↔99
Disulfide bond84↔131
Glycosylation130N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Strongly expressed in lung, breast, immune system and fetal tissues.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Heterodimer of CALCRL and RAMP2.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY O60895CALCRL Q166026EBI-9009040, EBI-962878
BINARY O60895CIDEB Q9UHD43EBI-9009040, EBI-7062247
BINARY O60895LCN2 P801883EBI-9009040, EBI-11911016
View interactors in UniProtKB
View CPX-2191 in Complex Portal

Protein-protein interaction databases

Chemistry

Miscellaneous

Family & Domains

Sequence similarities

Belongs to the RAMP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

O60895-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    175
  • Mass (Da)
    19,608
  • Last updated
    2003-01-10 v2
  • Checksum
    AF69A9A461EFFCA3
MASLRVERAGGPRLPRTRVGRPAALRLLLLLGAVLNPHEALAQPLPTTGTPGSEGGTVKNYETAVQFCWNHYKDQMDPIEKDWCDWAMISRPYSTLRDCLEHFAELFDLGFPNPLAERIIFETHQIHFANCSLVQPTFSDPPEDVLLAMIIAPICLIPFLITLVVWRSKDSEAQA

O60895-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
K7EKQ3K7EKQ3_HUMANRAMP2112
K7ENJ8K7ENJ8_HUMANRAMP249
K7EPN3K7EPN3_HUMANRAMP2100

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict13in Ref. 2; ABS28868
Sequence conflict25in Ref. 1; CAA04473
Alternative sequenceVSP_05583854in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ001015
EMBL· GenBank· DDBJ
CAA04473.1
EMBL· GenBank· DDBJ
mRNA
EF687002
EMBL· GenBank· DDBJ
ABS28868.1
EMBL· GenBank· DDBJ
mRNA
AY265458
EMBL· GenBank· DDBJ
AAP23299.1
EMBL· GenBank· DDBJ
mRNA
AC100793
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC027975
EMBL· GenBank· DDBJ
AAH27975.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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