O60809 · PRA10_HUMAN
- ProteinPRAME family member 10
- GenePRAMEF10
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids474 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Biological Process | negative regulation of apoptotic process | |
Biological Process | negative regulation of cell differentiation | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | positive regulation of cell population proliferation |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePRAME family member 10
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO60809
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_029104 | 99 | in dbSNP:rs3121398 | |||
Sequence: K → I | ||||||
Natural variant | VAR_029105 | 144 | in dbSNP:rs2797709 | |||
Sequence: R → H | ||||||
Natural variant | VAR_029106 | 306 | in dbSNP:rs848424 | |||
Sequence: T → A | ||||||
Natural variant | VAR_029107 | 402 | in dbSNP:rs1736772 | |||
Sequence: R → G |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,427 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000156984 | 1-474 | PRAME family member 10 | |||
Sequence: MSLQAPSRLLELAGQSLLRNQFLTIFTLDELPREVFPLMFMEAFSMRRFEALKLMVQAWPFLRLPLGSLMKTPHLETLQAVLRGLDTLVAQKVRPRRWKLQVLDLRDVDENFWTIWSGARVLSCSPEAMSKRQTVEDCPRMGERQPLKVFIDLCLKESTLDECLSYLFGWIHYRRGLVHLCCSKVQNYSMPTSSFRNLLERIYPDSIQELEVWKKCSLNKTGKFAPYLSQMSNLRELFLAFGYERELYVSVQWPCIPDLDSPFLCLYYPQMLYIKKISNIKEHLEHLLRYLKNPLGAFIFSDAYLTDRDMECLSQYPSLSQLKELRLIHILMWTTNLEPLGVLLEKVAATLKTLVLKDCRIQDPQLRVLLPALSHCSQLTTFNFHGNETSMNALKDLLRHTRGLSKLGLELYPAPLESLDYKGHVNWEILTPIRAELMRTLREVRQPKRIFFGPVPCPNCGSWPSEKVDFHLCS |
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | O60809 | AIP O00170 | 2 | EBI-21648956, EBI-704197 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 97-124 | LRR 1; degenerate | ||||
Sequence: RWKLQVLDLRDVDENFWTIWSGARVLSC | ||||||
Repeat | 179-203 | LRR 2; degenerate | ||||
Sequence: HLCCSKVQNYSMPTSSFRNLLERIY | ||||||
Repeat | 204-230 | LRR 3; degenerate | ||||
Sequence: PDSIQELEVWKKCSLNKTGKFAPYLSQ | ||||||
Repeat | 231-265 | LRR 4; degenerate | ||||
Sequence: MSNLRELFLAFGYERELYVSVQWPCIPDLDSPFLC | ||||||
Repeat | 266-291 | LRR 5 | ||||
Sequence: LYYPQMLYIKKISNIKEHLEHLLRYL | ||||||
Repeat | 292-323 | LRR 6 | ||||
Sequence: KNPLGAFIFSDAYLTDRDMECLSQYPSLSQLK | ||||||
Repeat | 324-342 | LRR 7 | ||||
Sequence: ELRLIHILMWTTNLEPLGV | ||||||
Repeat | 348-375 | LRR 8 | ||||
Sequence: AATLKTLVLKDCRIQDPQLRVLLPALSH | ||||||
Repeat | 376-400 | LRR 9 | ||||
Sequence: CSQLTTFNFHGNETSMNALKDLLRH |
Sequence similarities
Belongs to the PRAME family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length474
- Mass (Da)55,211
- Last updated2016-01-20 v4
- Checksum55DEAAD7962DC5E0
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 63 | in Ref. 2; AAI12209/AAI12211 and 3; CAB41254 | ||||
Sequence: R → S | ||||||
Sequence conflict | 73 | in Ref. 2; AAI12209/AAI12211 and 3; CAB41254 | ||||
Sequence: P → L | ||||||
Sequence conflict | 336 | in Ref. 2; AAI12209/AAI12211 and 3; CAB41254 | ||||
Sequence: N → H |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC245034 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL022101 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC112208 EMBL· GenBank· DDBJ | AAI12209.1 EMBL· GenBank· DDBJ | mRNA | ||
BC112210 EMBL· GenBank· DDBJ | AAI12211.1 EMBL· GenBank· DDBJ | mRNA | ||
AL049682 EMBL· GenBank· DDBJ | CAB41254.1 EMBL· GenBank· DDBJ | mRNA |