O60755 · GALR3_HUMAN

  • Protein
    Galanin receptor type 3
  • Gene
    GALR3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Receptor for the hormone galanin (PubMed:25691535).
Receptor for the hormone spexin-1 (PubMed:24517231).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcilium
Cellular Componentmembrane
Cellular Componentnon-motile cilium
Cellular Componentplasma membrane
Cellular Componentsynapse
Molecular Functiongalanin receptor activity
Molecular Functionpeptide hormone binding
Biological Processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
Biological Processchemical synaptic transmission
Biological Processfeeding behavior
Biological ProcessG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Biological Processgalanin-activated signaling pathway
Biological Processlearning or memory
Biological Processnegative regulation of adenylate cyclase activity
Biological Processneuropeptide signaling pathway
Biological Processpositive regulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Galanin receptor type 3
  • Short names
    GAL3-R; GALR-3

Gene names

    • Name
      GALR3
    • Synonyms
      GALNR3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    O60755
  • Secondary accessions
    • Q53YJ4

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-20Extracellular
Transmembrane21-41Helical; Name=1
Topological domain42-57Cytoplasmic
Transmembrane58-78Helical; Name=2
Topological domain79-96Extracellular
Transmembrane97-118Helical; Name=3
Topological domain119-138Cytoplasmic
Transmembrane139-159Helical; Name=4
Topological domain160-184Extracellular
Transmembrane185-205Helical; Name=5
Topological domain206-236Cytoplasmic
Transmembrane237-257Helical; Name=6
Topological domain258-259Extracellular
Transmembrane260-280Helical; Name=7
Topological domain281-368Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_049387342in dbSNP:rs8137541
Natural variantVAR_059322349in dbSNP:rs8137553

Variants

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The viewer provides 516 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond, lipidation.

TypeIDPosition(s)Description
ChainPRO_00000694691-368Galanin receptor type 3
Glycosylation6N-linked (GlcNAc...) asparagine
Disulfide bond95↔172
Lipidation308S-palmitoyl cysteine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Chemistry

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region317-368Disordered

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Length
    368
  • Mass (Da)
    39,573
  • Last updated
    1998-08-01 v1
  • Checksum
    E8F46B66422C3150
MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF073799
EMBL· GenBank· DDBJ
AAC35944.1
EMBL· GenBank· DDBJ
mRNA
AF067733
EMBL· GenBank· DDBJ
AAC18860.1
EMBL· GenBank· DDBJ
mRNA
AF129514
EMBL· GenBank· DDBJ
AAD47348.2
EMBL· GenBank· DDBJ
Genomic DNA
AF129513
EMBL· GenBank· DDBJ
AAD47348.2
EMBL· GenBank· DDBJ
Genomic DNA
AY587582
EMBL· GenBank· DDBJ
AAS98215.1
EMBL· GenBank· DDBJ
mRNA
AB065934
EMBL· GenBank· DDBJ
BAC06149.1
EMBL· GenBank· DDBJ
Genomic DNA
Z97630
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471095
EMBL· GenBank· DDBJ
EAW60191.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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