O60755 · GALR3_HUMAN
- ProteinGalanin receptor type 3
- GeneGALR3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids368 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Receptor for the hormone galanin (PubMed:25691535).
Receptor for the hormone spexin-1 (PubMed:24517231).
Receptor for the hormone spexin-1 (PubMed:24517231).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cilium | |
Cellular Component | membrane | |
Cellular Component | non-motile cilium | |
Cellular Component | plasma membrane | |
Cellular Component | synapse | |
Molecular Function | galanin receptor activity | |
Molecular Function | peptide hormone binding | |
Biological Process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | |
Biological Process | chemical synaptic transmission | |
Biological Process | feeding behavior | |
Biological Process | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | |
Biological Process | galanin-activated signaling pathway | |
Biological Process | learning or memory | |
Biological Process | negative regulation of adenylate cyclase activity | |
Biological Process | neuropeptide signaling pathway | |
Biological Process | positive regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGalanin receptor type 3
- Short namesGAL3-R; GALR-3
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO60755
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-20 | Extracellular | ||||
Sequence: MADAQNISLDSPGSVGAVAV | ||||||
Transmembrane | 21-41 | Helical; Name=1 | ||||
Sequence: PVVFALIFLLGTVGNGLVLAV | ||||||
Topological domain | 42-57 | Cytoplasmic | ||||
Sequence: LLQPGPSAWQEPGSTT | ||||||
Transmembrane | 58-78 | Helical; Name=2 | ||||
Sequence: DLFILNLAVADLCFILCCVPF | ||||||
Topological domain | 79-96 | Extracellular | ||||
Sequence: QATIYTLDAWLFGALVCK | ||||||
Transmembrane | 97-118 | Helical; Name=3 | ||||
Sequence: AVHLLIYLTMYASSFTLAAVSV | ||||||
Topological domain | 119-138 | Cytoplasmic | ||||
Sequence: DRYLAVRHPLRSRALRTPRN | ||||||
Transmembrane | 139-159 | Helical; Name=4 | ||||
Sequence: ARAAVGLVWLLAALFSAPYLS | ||||||
Topological domain | 160-184 | Extracellular | ||||
Sequence: YYGTVRYGALELCVPAWEDARRRAL | ||||||
Transmembrane | 185-205 | Helical; Name=5 | ||||
Sequence: DVATFAAGYLLPVAVVSLAYG | ||||||
Topological domain | 206-236 | Cytoplasmic | ||||
Sequence: RTLRFLWAAVGPAGAAAAEARRRATGRAGRA | ||||||
Transmembrane | 237-257 | Helical; Name=6 | ||||
Sequence: MLAVAALYALCWGPHHALILC | ||||||
Topological domain | 258-259 | Extracellular | ||||
Sequence: FW | ||||||
Transmembrane | 260-280 | Helical; Name=7 | ||||
Sequence: YGRFAFSPATYACRLASHCLA | ||||||
Topological domain | 281-368 | Cytoplasmic | ||||
Sequence: YANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_049387 | 342 | in dbSNP:rs8137541 | |||
Sequence: R → G | ||||||
Natural variant | VAR_059322 | 349 | in dbSNP:rs8137553 | |||
Sequence: Q → R |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 516 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond, lipidation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000069469 | 1-368 | Galanin receptor type 3 | |||
Sequence: MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE | ||||||
Glycosylation | 6 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 95↔172 | |||||
Sequence: CKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELC | ||||||
Lipidation | 308 | S-palmitoyl cysteine | ||||
Sequence: C |
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 317-368 | Disordered | ||||
Sequence: RRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE |
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length368
- Mass (Da)39,573
- Last updated1998-08-01 v1
- ChecksumE8F46B66422C3150
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF073799 EMBL· GenBank· DDBJ | AAC35944.1 EMBL· GenBank· DDBJ | mRNA | ||
AF067733 EMBL· GenBank· DDBJ | AAC18860.1 EMBL· GenBank· DDBJ | mRNA | ||
AF129514 EMBL· GenBank· DDBJ | AAD47348.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF129513 EMBL· GenBank· DDBJ | AAD47348.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY587582 EMBL· GenBank· DDBJ | AAS98215.1 EMBL· GenBank· DDBJ | mRNA | ||
AB065934 EMBL· GenBank· DDBJ | BAC06149.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z97630 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471095 EMBL· GenBank· DDBJ | EAW60191.1 EMBL· GenBank· DDBJ | Genomic DNA |