O60494 · CUBN_HUMAN
- ProteinCubilin
- GeneCUBN
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids3623 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake (PubMed:10371504, PubMed:11606717, PubMed:11717447, PubMed:14576052, PubMed:9572993).
Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex (PubMed:14576052, PubMed:9572993).
Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium (PubMed:9572993).
Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface
Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex (PubMed:14576052, PubMed:9572993).
Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium (PubMed:9572993).
Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface
Features
Showing features for site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 35-36 | Cleavage; by furin | ||||
Sequence: RS | ||||||
Binding site | 980 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 988 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 1027 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 1029 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 1030 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: L | ||||||
Binding site | 1096 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 1105 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 1146 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 1148 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: I | ||||||
Binding site | 1149 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 1213 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 1221 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 1262 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 1264 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 1265 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 1328 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 1336 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 1373 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 1375 | Ca2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: V |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameCubilin
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO60494
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Peripheral membrane protein
Cell membrane ; Peripheral membrane protein
Lysosome membrane ; Peripheral membrane protein
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Imerslund-Grasbeck syndrome 1 (IGS1)
- Note
- DescriptionA form of Imerslund-Grasbeck syndrome, a rare autosomal recessive disorder characterized by vitamin B12 deficiency commonly resulting in megaloblastic anemia, which is responsive to parenteral vitamin B12 therapy and appears in infancy or early childhood. Clinical manifestations include failure to thrive, infections and neurological damage. Mild proteinuria, with no signs of kidney disease, is present in about half of the patients.
- See alsoMIM:261100
Natural variants in IGS1
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_084401 | 337 | P>L | in IGS1; dbSNP:rs202153130 | |
VAR_084402 | 1112 | G>E | in IGS1; uncertain significance; results in intracellular retention of the mutant protein; dbSNP:rs2131820786 | |
VAR_025288 | 1297 | P>L | in IGS1; decreases strongly the CBLIF binding affinity; dbSNP:rs121434430 |
Proteinuria, chronic benign (PROCHOB)
- Note
- DescriptionAn autosomal recessive condition characterized by isolated, non-progressive proteinuria in absence of renal disease and hypertension. Onset of proteinuria is in the first decade of life.
- See alsoMIM:618884
Natural variants in PROCHOB
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_084400 | 55 | T>M | in PROCHOB; uncertain significance; dbSNP:rs774556167 | |
VAR_084403 | 1158-3623 | missing | in PROCHOB | |
VAR_084404 | 1303 | N>H | in PROCHOB; uncertain significance; dbSNP:rs200203056 | |
VAR_084405 | 1487-3623 | missing | in PROCHOB | |
VAR_084407 | 1810-3623 | missing | in PROCHOB | |
VAR_084408 | 1854 | D>Y | in PROCHOB; uncertain significance | |
VAR_084409 | 1928 | G>V | in PROCHOB; uncertain significance; dbSNP:rs201513648 | |
VAR_084410 | 1947 | S>Y | in PROCHOB; uncertain significance; dbSNP:rs147617753 | |
VAR_084411 | 2030-3623 | missing | in PROCHOB | |
VAR_084413 | 2261 | L>R | in PROCHOB; uncertain significance; dbSNP:rs779959064 | |
VAR_084414 | 2599 | C>W | in PROCHOB; uncertain significance; dbSNP:rs138758085 | |
VAR_084415 | 2822 | P>L | in PROCHOB; uncertain significance; dbSNP:rs776663892 | |
VAR_084416 | 2831-3623 | missing | in PROCHOB | |
VAR_084417 | 2833-3623 | missing | in PROCHOB | |
VAR_084418 | 2903-3623 | missing | in PROCHOB | |
VAR_084419 | 3018 | Y>S | in PROCHOB; uncertain significance; dbSNP:rs370778353 | |
VAR_084420 | 3027 | G>R | in PROCHOB; uncertain significance; dbSNP:rs150202444 | |
VAR_084421 | 3308 | W>R | in PROCHOB; uncertain significance; dbSNP:rs752843169 | |
VAR_084422 | 3317-3623 | missing | in PROCHOB | |
VAR_084423 | 3366 | S>C | in PROCHOB; uncertain significance; dbSNP:rs201157846 | |
VAR_084424 | 3492 | D>Y | in PROCHOB; uncertain significance; dbSNP:rs764917718 | |
VAR_084425 | 3520 | G>D | in PROCHOB; uncertain significance | |
VAR_084426 | 3609 | D>H | in PROCHOB; uncertain significance; dbSNP:rs775742147 | |
VAR_084427 | 3618-3623 | missing | in PROCHOB; uncertain significance |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_084400 | 55 | in PROCHOB; uncertain significance; dbSNP:rs774556167 | |||
Sequence: T → M | ||||||
Natural variant | VAR_047443 | 66 | in dbSNP:rs12259370 | |||
Sequence: G → R | ||||||
Natural variant | VAR_025284 | 124 | in dbSNP:rs1801220 | |||
Sequence: F → I | ||||||
Natural variant | VAR_025285 | 253 | in dbSNP:rs1801222 | |||
Sequence: F → S | ||||||
Natural variant | VAR_061154 | 335 | in dbSNP:rs57335729 | |||
Sequence: A → T | ||||||
Natural variant | VAR_084401 | 337 | in IGS1; dbSNP:rs202153130 | |||
Sequence: P → L | ||||||
Natural variant | VAR_025286 | 389 | in dbSNP:rs1801224 | |||
Sequence: P → T | ||||||
Natural variant | VAR_047444 | 504 | in dbSNP:rs2228053 | |||
Sequence: I → M | ||||||
Natural variant | VAR_047445 | 730 | in dbSNP:rs7905349 | |||
Sequence: H → Y | ||||||
Natural variant | VAR_035829 | 786 | in a breast cancer sample; somatic mutation; dbSNP:rs1228797857 | |||
Sequence: H → Q | ||||||
Natural variant | VAR_047446 | 969 | in dbSNP:rs11254354 | |||
Sequence: L → V | ||||||
Natural variant | VAR_025287 | 1032 | in dbSNP:rs1801227 | |||
Sequence: Y → H | ||||||
Natural variant | VAR_084402 | 1112 | in IGS1; uncertain significance; results in intracellular retention of the mutant protein; dbSNP:rs2131820786 | |||
Sequence: G → E | ||||||
Natural variant | VAR_084403 | 1158-3623 | in PROCHOB | |||
Sequence: Missing | ||||||
Natural variant | VAR_025288 | 1297 | in IGS1; decreases strongly the CBLIF binding affinity; dbSNP:rs121434430 | |||
Sequence: P → L | ||||||
Natural variant | VAR_084404 | 1303 | in PROCHOB; uncertain significance; dbSNP:rs200203056 | |||
Sequence: N → H | ||||||
Natural variant | VAR_084405 | 1487-3623 | in PROCHOB | |||
Sequence: Missing | ||||||
Natural variant | VAR_025289 | 1545 | ||||
Sequence: N → Y | ||||||
Natural variant | VAR_025290 | 1559 | in dbSNP:rs1801231 | |||
Sequence: P → S | ||||||
Natural variant | VAR_084406 | 1690 | found in individuals with albuminuria; uncertain significance; dbSNP:rs141640975 | |||
Sequence: A → V | ||||||
Natural variant | VAR_025291 | 1769 | in dbSNP:rs74116778 | |||
Sequence: V → I | ||||||
Natural variant | VAR_047447 | 1775 | in dbSNP:rs1276708 | |||
Sequence: R → W | ||||||
Natural variant | VAR_084407 | 1810-3623 | in PROCHOB | |||
Sequence: Missing | ||||||
Natural variant | VAR_047448 | 1840 | in dbSNP:rs2271462 | |||
Sequence: G → S | ||||||
Natural variant | VAR_084408 | 1854 | in PROCHOB; uncertain significance | |||
Sequence: D → Y | ||||||
Natural variant | VAR_084409 | 1928 | in PROCHOB; uncertain significance; dbSNP:rs201513648 | |||
Sequence: G → V | ||||||
Natural variant | VAR_047449 | 1935 | in dbSNP:rs41289305 | |||
Sequence: S → G | ||||||
Natural variant | VAR_084410 | 1947 | in PROCHOB; uncertain significance; dbSNP:rs147617753 | |||
Sequence: S → Y | ||||||
Natural variant | VAR_047450 | 1971 | in dbSNP:rs2356590 | |||
Sequence: P → T | ||||||
Natural variant | VAR_084411 | 2030-3623 | in PROCHOB | |||
Sequence: Missing | ||||||
Natural variant | VAR_025292 | 2153 | higher frequency in West Africans than in individuals of European ancestry; occurs with variants V-2984 and G-3002 only in individuals of European ancestry; dbSNP:rs62619939 | |||
Sequence: L → F | ||||||
Natural variant | VAR_084412 | 2157 | in dbSNP:rs144360241 | |||
Sequence: N → D | ||||||
Natural variant | VAR_025293 | 2162 | in dbSNP:rs1276712 | |||
Sequence: C → Y | ||||||
Natural variant | VAR_035830 | 2252 | in a colorectal cancer sample; somatic mutation; dbSNP:rs529856485 | |||
Sequence: A → V | ||||||
Natural variant | VAR_084413 | 2261 | in PROCHOB; uncertain significance; dbSNP:rs779959064 | |||
Sequence: L → R | ||||||
Natural variant | VAR_047451 | 2263 | in dbSNP:rs2271460 | |||
Sequence: F → C | ||||||
Natural variant | VAR_047452 | 2444 | in dbSNP:rs11254274 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_025294 | 2575 | in dbSNP:rs3740168 | |||
Sequence: P → R | ||||||
Natural variant | VAR_084414 | 2599 | in PROCHOB; uncertain significance; dbSNP:rs138758085 | |||
Sequence: C → W | ||||||
Natural variant | VAR_025295 | 2691 | in dbSNP:rs1801237 | |||
Sequence: G → R | ||||||
Natural variant | VAR_025296 | 2717 | in dbSNP:rs2796835 | |||
Sequence: S → W | ||||||
Natural variant | VAR_084415 | 2822 | in PROCHOB; uncertain significance; dbSNP:rs776663892 | |||
Sequence: P → L | ||||||
Natural variant | VAR_084416 | 2831-3623 | in PROCHOB | |||
Sequence: Missing | ||||||
Natural variant | VAR_084417 | 2833-3623 | in PROCHOB | |||
Sequence: Missing | ||||||
Natural variant | VAR_025297 | 2879 | in dbSNP:rs1801238 | |||
Sequence: L → I | ||||||
Natural variant | VAR_084418 | 2903-3623 | in PROCHOB | |||
Sequence: Missing | ||||||
Natural variant | VAR_035831 | 2914 | in a breast cancer sample; somatic mutation; dbSNP:rs45551835 | |||
Sequence: A → V | ||||||
Natural variant | VAR_047453 | 2968 | in dbSNP:rs45569534 | |||
Sequence: E → Q | ||||||
Natural variant | VAR_025298 | 2984 | not found in West Africans; occurs with variants F-2153 and G-3002 only in individuals of European ancestry; dbSNP:rs1801239 | |||
Sequence: I → V | ||||||
Natural variant | VAR_025299 | 3002 | higher frequency in West Africans than in individuals of European ancestry; occurs with variants F-2153 and V-2984 only in individuals of European ancestry; dbSNP:rs1801240 | |||
Sequence: E → G | ||||||
Natural variant | VAR_084419 | 3018 | in PROCHOB; uncertain significance; dbSNP:rs370778353 | |||
Sequence: Y → S | ||||||
Natural variant | VAR_084420 | 3027 | in PROCHOB; uncertain significance; dbSNP:rs150202444 | |||
Sequence: G → R | ||||||
Natural variant | VAR_035832 | 3189 | in a breast cancer sample; somatic mutation; dbSNP:rs111265129 | |||
Sequence: I → V | ||||||
Natural variant | VAR_064704 | 3258 | found in a renal cell carcinoma case; somatic mutation | |||
Sequence: S → G | ||||||
Natural variant | VAR_084421 | 3308 | in PROCHOB; uncertain significance; dbSNP:rs752843169 | |||
Sequence: W → R | ||||||
Natural variant | VAR_084422 | 3317-3623 | in PROCHOB | |||
Sequence: Missing | ||||||
Natural variant | VAR_084423 | 3366 | in PROCHOB; uncertain significance; dbSNP:rs201157846 | |||
Sequence: S → C | ||||||
Natural variant | VAR_025300 | 3422 | in dbSNP:rs1801230 | |||
Sequence: T → I | ||||||
Natural variant | VAR_055714 | 3432 | in dbSNP:rs7898873 | |||
Sequence: T → S | ||||||
Natural variant | VAR_084424 | 3492 | in PROCHOB; uncertain significance; dbSNP:rs764917718 | |||
Sequence: D → Y | ||||||
Natural variant | VAR_084425 | 3520 | in PROCHOB; uncertain significance | |||
Sequence: G → D | ||||||
Natural variant | VAR_025301 | 3552 | in dbSNP:rs1801232 | |||
Sequence: N → K | ||||||
Natural variant | VAR_084426 | 3609 | in PROCHOB; uncertain significance; dbSNP:rs775742147 | |||
Sequence: D → H | ||||||
Natural variant | VAR_084427 | 3618-3623 | in PROCHOB; uncertain significance | |||
Sequence: Missing |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 4,649 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for signal, propeptide, chain, glycosylation, disulfide bond, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MMNMSLPFLWSLLTLLIFAEVNG | ||||||
Propeptide | PRO_0000046072 | 24-35 | Removed in mature form | |||
Sequence: EAGELELQRQKR | ||||||
Chain | PRO_0000046073 | 36-3623 | Cubilin | |||
Sequence: SINLQQPRMATERGNLVFLTGSAQNIEFRTGSLGKIKLNDEDLSECLHQIQKNKEDIIELKGSAIGLPQNISSQIYQLNSKLVDLERKFQGLQQTVDKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLSHPCLNGQCIDTVSGYFCKCDSGWTGVNCTENINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSDLRCGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDGETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVACGDELTGEGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTGCGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQTCENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGPRQMGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVYGCGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREGNATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKIFGNDNIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHARLIGAYCGTQTESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTIAPGACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDSTVELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKSCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEAKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSEDAVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVGDADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFTDCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTLGCGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEAPAQGFSASFVSRCGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCGDEMPAPLTIAGPVLLNFYSNEQITDFGFKFSYRIISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGPQQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIMDMPCGGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQDCTQNYLQLQDSPQGHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSSPSGCGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAFRLTWDS | ||||||
Glycosylation | 105 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 136↔147 | |||||
Sequence: CSSNPCQNGGTC | ||||||
Disulfide bond | 141↔156 | |||||
Sequence: CQNGGTCLNLHDSFFC | ||||||
Disulfide bond | 158↔167 | |||||
Sequence: CPPQWKGPLC | ||||||
Disulfide bond | 174↔190 | |||||
Sequence: CEIYSGTPLSCQNGGTC | ||||||
Disulfide bond | 184↔199 | |||||
Sequence: CQNGGTCVNTMGSYSC | ||||||
Disulfide bond | 201↔210 | |||||
Sequence: CPPETYGPQC | ||||||
Disulfide bond | 267↔280 | |||||
Sequence: CSFQPGPCSTLVQC | ||||||
Disulfide bond | 274↔289 | |||||
Sequence: CSTLVQCFNTQGSFYC | ||||||
Disulfide bond | 292↔303 | |||||
Sequence: CPTGWQGNGYIC | ||||||
Disulfide bond | 353↔366 | |||||
Sequence: CSVSNGGCHPDASC | ||||||
Disulfide bond | 360↔376 | |||||
Sequence: CHPDASCSSTLGSLPLC | ||||||
Disulfide bond | 399↔409 | |||||
Sequence: CLSHPCLNGQC | ||||||
Disulfide bond | 404↔418 | |||||
Sequence: CLNGQCIDTVSGYFC | ||||||
Disulfide bond | 420↔429 | |||||
Sequence: CDSGWTGVNC | ||||||
Glycosylation | 428 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 436↔447 | |||||
Sequence: CLSNPCLNGGTC | ||||||
Disulfide bond | 441↔456 | |||||
Sequence: CLNGGTCVDGVDSFSC | ||||||
Disulfide bond | 458↔467 | |||||
Sequence: CTRLWTGALC | ||||||
Disulfide bond | 474↔500 | |||||
Sequence: CGESLSGINGSFSYRSPDVGYVHDVNC | ||||||
Glycosylation | 482 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 527↔549 | |||||
Sequence: CPHEFLQVYDGDSSSAFQLGRFC | ||||||
Disulfide bond | 590↔616 | |||||
Sequence: CGGILTGPYGSIKSPGYPGNYPPGRDC | ||||||
Disulfide bond | 643↔665 | |||||
Sequence: CNKDYLEIRDGPLYQDPLLGKFC | ||||||
Disulfide bond | 708↔734 | |||||
Sequence: CGGNYTDPEGELFLPELSGPFTHTRQC | ||||||
Glycosylation | 711 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 749 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 781 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 857 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 869↔891 | |||||
Sequence: CETDYVEIGSSSILGSPENKKYC | ||||||
Disulfide bond | 932↔958 | |||||
Sequence: CGEILTESTGTIQSPGHPNVYPHGINC | ||||||
Glycosylation | 957 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 984 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 985↔1005 | |||||
Sequence: CTNDYLEVYDTDSETSLGRYC | ||||||
Disulfide bond | 1048↔1074 | |||||
Sequence: CLQDYTDDLGTFTSPNFPNNYPNNWEC | ||||||
Glycosylation | 1092 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 1165↔1191 | |||||
Sequence: CGGNLTTSSGTFISPNYPMPYYHSSEC | ||||||
Glycosylation | 1168 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 1217 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 1218↔1240 | |||||
Sequence: CTLDYLAVYDGPSSNSHLLTQLC | ||||||
Disulfide bond | 1278↔1306 | |||||
Sequence: CENVVIVNQTYGILESIGYPNPYSENQHC | ||||||
Glycosylation | 1285 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 1307 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 1319 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 1332 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 1333↔1351 | |||||
Sequence: CSTDYLELYDGPRQMGRYC | ||||||
Disulfide bond | 1391↔1417 | |||||
Sequence: CGGELSGATGSFSSPGFPNRYPPNKEC | ||||||
Disulfide bond | 1444↔1466 | |||||
Sequence: CNFDVLEIYGGPDFHSPRIAQLC | ||||||
Glycosylation | 1500 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 1510↔1536 | |||||
Sequence: CGGIFQAPSGEIHSPNYPSPYRSNTDC | ||||||
Glycosylation | 1551 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 1563↔1581 | |||||
Sequence: CIMAYDGLSSTMSRLARTC | ||||||
Disulfide bond | 1620↔1647 | |||||
Sequence: CGGHILTSSFDTVSSPRFPANYPNNQNC | ||||||
Glycosylation | 1646 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 1675↔1697 | |||||
Sequence: CARDFVEILDGGHEDAPLRGRYC | ||||||
Disulfide bond | 1738↔1764 | |||||
Sequence: CGGTFYMAEGIFNSPGYPDIYPPNVEC | ||||||
Disulfide bond | 1791↔1812 | |||||
Sequence: CSRDFVEIREGNATGHLVGRYC | ||||||
Glycosylation | 1802 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 1819 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 1885 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 1905↔1927 | |||||
Sequence: CYYDKLRIYDGPSIHARLIGAYC | ||||||
Disulfide bond | 1978↔2006 | |||||
Sequence: CGGFLRTGDAPVFLFSPGWPDSYSNRVDC | ||||||
Disulfide bond | 2032↔2054 | |||||
Sequence: CAYDSLVIRDGDNNLAQQLAVLC | ||||||
Glycosylation | 2085 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 2092↔2118 | |||||
Sequence: CGGYLHADRGIITSPKYPETYPSNLNC | ||||||
Glycosylation | 2117 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 2217↔2247 | |||||
Sequence: CGGNVYIHDADSAGYVTSPNHPHNYPPHADC | ||||||
Glycosylation | 2274 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 2275↔2297 | |||||
Sequence: CTSNYLELRDGVDSDAPILSKFC | ||||||
Disulfide bond | 2336↔2363 | |||||
Sequence: CGGRVPGQSGVVESIGHPTLPYRDNLFC | ||||||
Glycosylation | 2386 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 2390↔2411 | |||||
Sequence: CEKDFVEIWDNHTSGNILGRYC | ||||||
Glycosylation | 2400 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 2452↔2478 | |||||
Sequence: CGGDLQGSIGTFTSPNYPNPNPHGRIC | ||||||
Disulfide bond | 2505↔2527 | |||||
Sequence: CNNEHVIVFNGIRSNSPQLEKLC | ||||||
Glycosylation | 2531 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 2570↔2599 | |||||
Sequence: CGGSLPNTPEGNFTSPGYDGVRNYSRNLNC | ||||||
Glycosylation | 2581 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 2592 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 2610 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 2628↔2649 | |||||
Sequence: CQFDVLEFRVGDADGPLMWRLC | ||||||
Disulfide bond | 2689↔2715 | |||||
Sequence: CGGIQIGDSGVITSPNYPNAYDSLTHC | ||||||
Disulfide bond | 2742↔2764 | |||||
Sequence: CAWDSVTVRNGGSPESPIIGQYC | ||||||
Disulfide bond | 2805↔2831 | |||||
Sequence: CGGIFHSDNGTIRSPHWPQNFPENSRC | ||||||
Glycosylation | 2813 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 2860↔2883 | |||||
Sequence: CQNSFVKVWAGTEEVDKALLATGC | ||||||
Disulfide bond | 2920↔2946 | |||||
Sequence: CGSNFTGPSGYIISPNYPKQYDNNMNC | ||||||
Glycosylation | 2923 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 2945 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 2977↔2999 | |||||
Sequence: CVNDGVHIIRGYSVMSTPFATVC | ||||||
Modified residue | 3008 | Phosphothreonine | ||||
Sequence: T | ||||||
Disulfide bond | 3037↔3064 | |||||
Sequence: CGGVFNFSSGIITSPAYSYADYPNDMHC | ||||||
Glycosylation | 3042 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 3091↔3113 | |||||
Sequence: CSHDYLAIYDGANTSDPLLGKFC | ||||||
Glycosylation | 3103 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 3125 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 3157↔3185 | |||||
Sequence: CGGYLTGSNNTFASPDSDSNGMYDKNLNC | ||||||
Glycosylation | 3165 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 3215↔3237 | |||||
Sequence: CLYDYVKLYDGDSENANLAGTFC | ||||||
Glycosylation | 3268 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 3278↔3306 | |||||
Sequence: CGGTYNATWTPQNISSPNSSDPDVPFSIC | ||||||
Glycosylation | 3283 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 3290 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 3295 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 3332↔3354 | |||||
Sequence: CTQNYLQLQDSPQGHGNSRFQFC | ||||||
Glycosylation | 3357 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 3395↔3421 | |||||
Sequence: CNRDYHKAFGNLRSPGWPDNYDNDKDC | ||||||
Glycosylation | 3430 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 3448↔3470 | |||||
Sequence: CRNDFLEVRNGSNSNSPLLGKYC | ||||||
Glycosylation | 3457 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 3511↔3537 | |||||
Sequence: CGGTLYGDRGSFTSPGYPGTYPNNTYC | ||||||
Glycosylation | 3533 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 3564↔3586 | |||||
Sequence: CVQNYLTLYDGPNASSPSSGPYC | ||||||
Glycosylation | 3576 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Post-translational modification
The precursor is cleaved by a trans-Golgi proteinase furin, removing a propeptide.
N-glycosylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Detected in kidney cortex (at protein level) (PubMed:9572993).
Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney
Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with AMN (PubMed:14576052, PubMed:20237569, PubMed:29402915, PubMed:30523278).
Component of the cubam complex composed of one CUBN trimer and one AMN chain (PubMed:30523278).
The cubam complex can dimerize (By similarity).
Interacts with LRP2 in a dual-receptor complex in a calcium-dependent manner. Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with LRP1 and PID1/PCLI1
Component of the cubam complex composed of one CUBN trimer and one AMN chain (PubMed:30523278).
The cubam complex can dimerize (By similarity).
Interacts with LRP2 in a dual-receptor complex in a calcium-dependent manner. Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with LRP1 and PID1/PCLI1
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | O60494 | AMN Q9BXJ7 | 3 | EBI-3953632, EBI-11510881 | |
BINARY | O60494 | CBLIF P27352 | 2 | EBI-3953632, EBI-3953638 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 42-49 | Interaction with AMN | ||||
Sequence: PRMATERG | ||||||
Domain | 132-168 | EGF-like 1 | ||||
Sequence: DKKVCSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCS | ||||||
Domain | 170-211 | EGF-like 2; calcium-binding | ||||
Sequence: DVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCA | ||||||
Domain | 263-304 | EGF-like 3; calcium-binding | ||||
Sequence: DRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICE | ||||||
Domain | 305-348 | EGF-like 4; calcium-binding | ||||
Sequence: DINECEINNGGCSVAPPVECVNTPGSSHCQACPPGYQGDGRVCT | ||||||
Domain | 349-385 | EGF-like 5 | ||||
Sequence: LTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGN | ||||||
Domain | 395-430 | EGF-like 6 | ||||
Sequence: LSNICLSHPCLNGQCIDTVSGYFCKCDSGWTGVNCT | ||||||
Domain | 432-468 | EGF-like 7; calcium-binding | ||||
Sequence: NINECLSNPCLNGGTCVDGVDSFSCECTRLWTGALCQ | ||||||
Domain | 474-586 | CUB 1 | ||||
Sequence: CGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQ | ||||||
Domain | 590-702 | CUB 2 | ||||
Sequence: CGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTS | ||||||
Domain | 708-816 | CUB 3 | ||||
Sequence: CGGNYTDPEGELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDGETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVA | ||||||
Domain | 816-928 | CUB 4 | ||||
Sequence: ACGDELTGEGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFSAE | ||||||
Domain | 932-1042 | CUB 5 | ||||
Sequence: CGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAI | ||||||
Domain | 1048-1161 | CUB 6 | ||||
Sequence: CLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGS | ||||||
Domain | 1165-1277 | CUB 7 | ||||
Sequence: CGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQT | ||||||
Domain | 1278-1389 | CUB 8 | ||||
Sequence: CENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGPRQMGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVY | ||||||
Domain | 1391-1506 | CUB 9 | ||||
Sequence: CGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAV | ||||||
Domain | 1510-1619 | CUB 10 | ||||
Sequence: CGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQA | ||||||
Domain | 1620-1734 | CUB 11 | ||||
Sequence: CGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTVTAS | ||||||
Domain | 1738-1850 | CUB 12 | ||||
Sequence: CGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREGNATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATFMKI | ||||||
Domain | 1852-1963 | CUB 13 | ||||
Sequence: GNDNIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHARLIGAYCGTQTESFSSTGNSLTFHFYSDSSISGKGFLLEWFAV | ||||||
Domain | 1978-2091 | CUB 14 | ||||
Sequence: CGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDSTVELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKS | ||||||
Domain | 2092-2213 | CUB 15 | ||||
Sequence: CGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEAK | ||||||
Domain | 2217-2334 | CUB 16 | ||||
Sequence: CGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSIA | ||||||
Domain | 2336-2448 | CUB 17 | ||||
Sequence: CGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESS | ||||||
Domain | 2452-2565 | CUB 18 | ||||
Sequence: CGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSS | ||||||
Domain | 2570-2687 | CUB 19 | ||||
Sequence: CGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVGDADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFT | ||||||
Domain | 2689-2801 | CUB 20 | ||||
Sequence: CGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQ | ||||||
Domain | 2805-2919 | CUB 21 | ||||
Sequence: CGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEAPAQGFSASFVSR | ||||||
Domain | 2920-3035 | CUB 22 | ||||
Sequence: CGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVCGDEMPAPLTIAGPVLLNFYSNEQITDFGFKFSYRII | ||||||
Domain | 3037-3150 | CUB 23 | ||||
Sequence: CGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQT | ||||||
Domain | 3157-3274 | CUB 24 | ||||
Sequence: CGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIM | ||||||
Domain | 3278-3393 | CUB 25 | ||||
Sequence: CGGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQDCTQNYLQLQDSPQGHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQIA | ||||||
Domain | 3395-3507 | CUB 26 | ||||
Sequence: CNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEIIWTSS | ||||||
Domain | 3511-3623 | CUB 27 | ||||
Sequence: CGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAFRLTWDS |
Domain
The CUB domains 5 to 8 mediate binding to CBLIF and ALB. CUB domains 1 and 2 mediate interaction with LRP2.
The cubam complex is composed of a 400 Angstrom long stem and a globular crown region. The stem region is probably formed by AMN and the CUBN N-terminal region, including the EGF-like domains. The crown is probably formed by the CUBN CUB domains.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length3,623
- Mass (Da)398,736
- Last updated2010-11-02 v5
- Checksum8D602663C6D4751F
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H7C480 | H7C480_HUMAN | CUBN | 105 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 25 | in Ref. 1; AAC82612 | ||||
Sequence: A → R | ||||||
Sequence conflict | 146 | in Ref. 1; AAC82612 | ||||
Sequence: T → N |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF034611 EMBL· GenBank· DDBJ | AAC82612.1 EMBL· GenBank· DDBJ | mRNA | ||
EF444970 EMBL· GenBank· DDBJ | ACA05973.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF444970 EMBL· GenBank· DDBJ | ACA05974.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC067747 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL365215 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL596445 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL731551 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |