O60269 · GRIN2_HUMAN
- ProteinG protein-regulated inducer of neurite outgrowth 2
- GeneGPRIN2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids458 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May be involved in neurite outgrowth.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Biological Process | neuron projection development |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameG protein-regulated inducer of neurite outgrowth 2
- Short namesGRIN2
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO60269
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_059660 | 5 | in dbSNP:rs3127817 | |||
Sequence: R → H | ||||||
Natural variant | VAR_051017 | 39 | in dbSNP:rs4926045 | |||
Sequence: L → V | ||||||
Natural variant | VAR_059661 | 40 | in dbSNP:rs3127818 | |||
Sequence: R → H | ||||||
Natural variant | VAR_059662 | 47 | in dbSNP:rs3127819 | |||
Sequence: V → M | ||||||
Natural variant | VAR_059663 | 91 | in dbSNP:rs3127820 | |||
Sequence: W → R | ||||||
Natural variant | VAR_061656 | 100 | in dbSNP:rs7090312 | |||
Sequence: T → P | ||||||
Natural variant | VAR_051018 | 104 | in dbSNP:rs3127679 | |||
Sequence: S → G | ||||||
Natural variant | VAR_061657 | 202 | in dbSNP:rs11204658 | |||
Sequence: G → W | ||||||
Natural variant | VAR_061658 | 233 | in dbSNP:rs11204659 | |||
Sequence: A → S | ||||||
Natural variant | VAR_061659 | 241 | in dbSNP:rs9422022 | |||
Sequence: V → M | ||||||
Natural variant | VAR_061660 | 242 | in dbSNP:rs3127683 | |||
Sequence: R → G | ||||||
Natural variant | VAR_061661 | 328 | in dbSNP:rs4445576 | |||
Sequence: S → C | ||||||
Natural variant | VAR_061662 | 375 | in dbSNP:rs3127822 | |||
Sequence: V → A | ||||||
Natural variant | VAR_059664 | 400 | in dbSNP:rs3127823 | |||
Sequence: L → P |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,452 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000050759 | 1-458 | UniProt | G protein-regulated inducer of neurite outgrowth 2 | |||
Sequence: MSSSRPEPGPWAPLSPRLQPLSQSSSSLLGEGREQRPELRKTASSTVWQAQLGEASTRPQAPEEEGNPPESMKPARASGPKARPSAGGHWWSSTVGNVSTMGGSDLCRLRAPSAAAMQRSHSDLVRSTQMRGHSGARKASLSCSALGSSPVHRAQLQPGGTSGQGGQAPAGLERDLAPEDETSNSAWMLGASQLSVPPLDLGDTTAHSSSAQAEPKAAEQLATTTCHALPPAALLCGMREVRAGGCCHALPATGILAFPKLVASVSESGLQAQHGVKIHCRLSGGLPGHSHCCAHLWGPAGLVPEPGSRTKDVWTMTSANDLAPAEASPLSAQDAGVQAAPVAACKAVATSPSLEAPAALHVFPEVTLGSSLEEVPSPVRDVRWDAEGMTWEVYGAAVDLEVLGVAIQKHLEMQFEQLQRAPASEDSLSVEGRRGPLRAVMQSLRRPSCCGCSGAAPE | |||||||
Modified residue (large scale data) | 27 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 140 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 142 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 264 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 266 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 427 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 429 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
PTM databases
Interaction
Subunit
Interacts with activated forms of GNAO1 and GNAZ.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | O60269 | HTR4 Q13639 | 2 | EBI-740397, EBI-6656425 | |
BINARY | O60269 | SFN P31947 | 2 | EBI-740397, EBI-476295 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-94 | Disordered | ||||
Sequence: MSSSRPEPGPWAPLSPRLQPLSQSSSSLLGEGREQRPELRKTASSTVWQAQLGEASTRPQAPEEEGNPPESMKPARASGPKARPSAGGHWWSST | ||||||
Compositional bias | 17-31 | Polar residues | ||||
Sequence: RLQPLSQSSSSLLGE | ||||||
Compositional bias | 41-56 | Polar residues | ||||
Sequence: KTASSTVWQAQLGEAS | ||||||
Region | 118-172 | Disordered | ||||
Sequence: QRSHSDLVRSTQMRGHSGARKASLSCSALGSSPVHRAQLQPGGTSGQGGQAPAGL | ||||||
Compositional bias | 120-164 | Polar residues | ||||
Sequence: SHSDLVRSTQMRGHSGARKASLSCSALGSSPVHRAQLQPGGTSGQ |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length458
- Mass (Da)47,450
- Last updated2006-05-16 v2
- ChecksumD6395C187FAD142D
Sequence caution
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 17-31 | Polar residues | ||||
Sequence: RLQPLSQSSSSLLGE | ||||||
Compositional bias | 41-56 | Polar residues | ||||
Sequence: KTASSTVWQAQLGEAS | ||||||
Compositional bias | 120-164 | Polar residues | ||||
Sequence: SHSDLVRSTQMRGHSGARKASLSCSALGSSPVHRAQLQPGGTSGQ | ||||||
Sequence conflict | 241-242 | in Ref. 1; BAA25440 and 3; AAH11672 | ||||
Sequence: VR → MREVG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB011086 EMBL· GenBank· DDBJ | BAA25440.2 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AL645529 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC011672 EMBL· GenBank· DDBJ | AAH11672.1 EMBL· GenBank· DDBJ | mRNA |