O60256 · KPRB_HUMAN
- ProteinPhosphoribosyl pyrophosphate synthase-associated protein 2
- GenePRPSAP2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids369 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | ribose phosphate diphosphokinase complex | |
Molecular Function | ATP binding | |
Molecular Function | enzyme inhibitor activity | |
Molecular Function | identical protein binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | ribose phosphate diphosphokinase activity | |
Biological Process | 5-phosphoribose 1-diphosphate biosynthetic process | |
Biological Process | bone development | |
Biological Process | nucleobase-containing compound metabolic process | |
Biological Process | purine nucleotide biosynthetic process |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoribosyl pyrophosphate synthase-associated protein 2
- Short namesPRPP synthase-associated protein 2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionO60256
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 258 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue, chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue | 1 | UniProt | N-acetylmethionine | ||||
Sequence: M | |||||||
Chain | PRO_0000141082 | 1-369 | UniProt | Phosphoribosyl pyrophosphate synthase-associated protein 2 | |||
Sequence: MFCVTPPELETKMNITKGGLVLFSANSNSSCMELSKKIAERLGVEMGKVQVYQEPNRETRVQIQESVRGKDVFIIQTVSKDVNTTIMELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVRSVAAIHPSLEIPMLIPKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIPHEVQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFRNIGLDD | |||||||
Modified residue | 5 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 5 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 52 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 198 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 219 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 219 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 227 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 227 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 233 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 240 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Ubiquitous.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Binds to PRPS1 and PRPS2.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | O60256 | PRPS1 P60891 | 10 | EBI-724960, EBI-749195 | |
BINARY | O60256 | PRPS2 P11908-2 | 4 | EBI-724960, EBI-12063547 | |
BINARY | O60256 | PRPSAP1 Q14558 | 8 | EBI-724960, EBI-724449 | |
BINARY | O60256 | PRPSAP2 O60256 | 3 | EBI-724960, EBI-724960 | |
BINARY | O60256 | TEX11 Q8IYF3-3 | 3 | EBI-724960, EBI-11523345 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
O60256-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length369
- Mass (Da)40,926
- Last updated1998-08-01 v1
- Checksum12A0E46BD4AC55BF
O60256-2
- Name2
- Differences from canonical
- 41-80: Missing
O60256-3
- Name3
- Differences from canonical
- 269-317: Missing
O60256-4
- Name4
- Differences from canonical
- 1-86: Missing
Computationally mapped potential isoform sequences
There are 14 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E7EW35 | E7EW35_HUMAN | PRPSAP2 | 161 | ||
E7EPA1 | E7EPA1_HUMAN | PRPSAP2 | 268 | ||
C9K0K7 | C9K0K7_HUMAN | PRPSAP2 | 244 | ||
C9JJS3 | C9JJS3_HUMAN | PRPSAP2 | 194 | ||
C9JDH0 | C9JDH0_HUMAN | PRPSAP2 | 140 | ||
C9JDU5 | C9JDU5_HUMAN | PRPSAP2 | 176 | ||
I3L4G9 | I3L4G9_HUMAN | PRPSAP2 | 143 | ||
I3L3B8 | I3L3B8_HUMAN | PRPSAP2 | 57 | ||
I3L331 | I3L331_HUMAN | PRPSAP2 | 93 | ||
I3L2J4 | I3L2J4_HUMAN | PRPSAP2 | 78 | ||
I3L1T1 | I3L1T1_HUMAN | PRPSAP2 | 47 | ||
I3L275 | I3L275_HUMAN | PRPSAP2 | 22 | ||
I3L0S1 | I3L0S1_HUMAN | PRPSAP2 | 260 | ||
I3L164 | I3L164_HUMAN | PRPSAP2 | 104 |
Features
Showing features for alternative sequence, sequence conflict.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB007851 EMBL· GenBank· DDBJ | BAA25435.1 EMBL· GenBank· DDBJ | mRNA | ||
AK303911 EMBL· GenBank· DDBJ | BAG64840.1 EMBL· GenBank· DDBJ | mRNA | ||
AK304544 EMBL· GenBank· DDBJ | BAG65341.1 EMBL· GenBank· DDBJ | mRNA | ||
CR457082 EMBL· GenBank· DDBJ | CAG33363.1 EMBL· GenBank· DDBJ | mRNA | ||
AC090286 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC107982 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC106050 EMBL· GenBank· DDBJ | AAI06051.1 EMBL· GenBank· DDBJ | mRNA | ||
BC101670 EMBL· GenBank· DDBJ | AAI01671.1 EMBL· GenBank· DDBJ | mRNA | ||
BC101672 EMBL· GenBank· DDBJ | AAI01673.1 EMBL· GenBank· DDBJ | mRNA | ||
BC143475 EMBL· GenBank· DDBJ | AAI43476.1 EMBL· GenBank· DDBJ | mRNA |