O60245 · PCDH7_HUMAN

  • Protein
    Protocadherin-7
  • Gene
    PCDH7
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Cellular Componentplatelet alpha granule membrane
Molecular Functioncalcium ion binding
Biological Processcell adhesion
Biological Processhomophilic cell adhesion via plasma membrane adhesion molecules

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protocadherin-7
  • Alternative names
    • Brain-heart protocadherin (BH-Pcdh)

Gene names

    • Name
      PCDH7
    • Synonyms
      BHPCDH

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    O60245
  • Secondary accessions
    • O60246
    • O60247
    • Q4W5C4

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain29-879Extracellular
Transmembrane880-900Helical
Topological domain901-1069Cytoplasmic

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,433 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
Signal1-28UniProt
ChainPRO_000000399229-1069UniProtProtocadherin-7
Glycosylation79UniProtN-linked (GlcNAc...) asparagine
Glycosylation689UniProtN-linked (GlcNAc...) asparagine
Glycosylation747UniProtN-linked (GlcNAc...) asparagine
Glycosylation780UniProtN-linked (GlcNAc...) asparagine
Glycosylation822UniProtN-linked (GlcNAc...) asparagine
Glycosylation840UniProtN-linked (GlcNAc...) asparagine
Glycosylation845UniProtN-linked (GlcNAc...) asparagine
Modified residue (large scale data)924PRIDEPhosphothreonine
Modified residue (large scale data)948PRIDEPhosphotyrosine
Modified residue (large scale data)966PRIDEPhosphoserine
Modified residue (large scale data)972PRIDEPhosphoserine
Modified residue (large scale data)974PRIDEPhosphoserine
Modified residue (large scale data)976PRIDEPhosphoserine
Modified residue (large scale data)982PRIDEPhosphoserine
Modified residue989UniProtPhosphoserine
Modified residue (large scale data)989PRIDEPhosphoserine
Modified residue (large scale data)1000PRIDEPhosphoserine
Modified residue1011UniProtPhosphoserine
Modified residue (large scale data)1011PRIDEPhosphoserine
Modified residue (large scale data)1013PRIDEPhosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed predominantly in brain and heart and at lower levels in various other tissues.

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain29-143Cadherin 1
Domain144-308Cadherin 2
Region182-242Disordered
Domain309-415Cadherin 3
Domain424-535Cadherin 4
Domain536-639Cadherin 5
Domain640-742Cadherin 6
Domain745-862Cadherin 7
Compositional bias910-931Basic and acidic residues
Region910-988Disordered
Compositional bias945-979Polar residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative splicing.

O60245-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    A
  • Synonyms
    BH-Pcdh-a
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    1,069
  • Mass (Da)
    116,071
  • Last updated
    2009-07-28 v2
  • Checksum
    6150CAF0599D5DAF
MLRMRTAGWARGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLNYSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVMARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPNGQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQAVQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQMRLHPYITVFG

O60245-2

  • Name
    B
  • Synonyms
    BH-Pcdh-b
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8V8TM73A0A8V8TM73_HUMANPCDH71247
A0A8Q3SIA5A0A8Q3SIA5_HUMANPCDH71065
A0A8Q3SI47A0A8Q3SI47_HUMANPCDH71228
A0A8Q3SI70A0A8Q3SI70_HUMANPCDH71255
A0A8Q3SI92A0A8Q3SI92_HUMANPCDH71219
A0A087X0C9A0A087X0C9_HUMANPCDH7125
A0A087X2C4A0A087X2C4_HUMANPCDH71269

Sequence caution

The sequence BAA25196.1 differs from that shown. Reason: Miscellaneous discrepancy Aberrant splicing.

Features

Showing features for sequence conflict, compositional bias, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict25in Ref. 1; BAA25194/BAA25195/BAA25196
Sequence conflict518in Ref. 1; BAA25194/BAA25195/BAA25196
Sequence conflict834in Ref. 1; BAA25194/BAA25195/BAA25196
Compositional bias910-931Basic and acidic residues
Compositional bias945-979Polar residues
Alternative sequenceVSP_0007041059-1069in isoform B

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB006755
EMBL· GenBank· DDBJ
BAA25194.1
EMBL· GenBank· DDBJ
mRNA
AB006756
EMBL· GenBank· DDBJ
BAA25195.1
EMBL· GenBank· DDBJ
mRNA
AB006757
EMBL· GenBank· DDBJ
BAA25196.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AC097716
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC098595
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC107394
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC110766
EMBL· GenBank· DDBJ
AAY40944.1
EMBL· GenBank· DDBJ
Genomic DNA
AC112239
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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