O59751 · KLP6_SCHPO

Function

function

Has a role in establishing metaphase during mitosis. Required for chromosome segregation where it generates tension during kinetochore capturing.

Features

Showing features for binding site.

1784100200300400500600700
TypeIDPosition(s)Description
Binding site134-141ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcortical microtubule
Cellular Componentcytoplasm
Cellular Componentcytoplasmic microtubule plus-end
Cellular Componentcytosol
Cellular Componentkinesin complex
Cellular Componentkinesin I complex
Cellular Componentkinetochore
Cellular Componentmicrotubule cytoskeleton
Cellular Componentmitotic spindle
Cellular Componentmitotic spindle astral microtubule
Cellular Componentmitotic spindle midzone
Cellular Componentmitotic spindle pole body
Cellular Componentnucleus
Cellular Componentplus-end kinesin complex
Cellular Componentpost-anaphase microtubule array
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionmicrotubule binding
Molecular Functionplus-end-directed microtubule motor activity
Biological Processcell division
Biological Processdeactivation of mitotic spindle assembly checkpoint
Biological Processmicrotubule depolymerization
Biological Processmicrotubule-based movement
Biological Processmitotic chromosome movement towards spindle pole
Biological Processmitotic metaphase chromosome recapture
Biological Processmitotic sister chromatid biorientation
Biological Processmitotic sister chromatid segregation
Biological Processmitotic spindle elongation
Biological Processmitotic spindle formation (spindle phase one)
Biological Processmitotic spindle organization
Biological Processplus-end specific microtubule depolymerization
Biological Processprotein transport along microtubule to kinetochore

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Kinesin-like protein 6

Gene names

    • Name
      klp6
    • ORF names
      SPBC1685.15c, SPBC649.01c

Organism names

Accessions

  • Primary accession
    O59751
  • Secondary accessions
    • Q9UTZ7

Proteomes

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

Simultaneous disruption of dam1 is lethal and leads to the cut phenotype (septation without chromosome segregation).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001253891-784Kinesin-like protein 6

Proteomic databases

PTM databases

Interaction

Subunit

Heterodimer with klp5.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY O59751klp5 O143433EBI-1561745, EBI-1561765

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, coiled coil, region, compositional bias.

Type
IDPosition(s)Description
Domain6-389Kinesin motor
Coiled coil405-440
Coiled coil463-483
Region677-715Disordered
Compositional bias691-708Basic and acidic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    784
  • Mass (Da)
    87,796
  • Last updated
    1998-08-01 v1
  • Checksum
    EBE985FF79C18BB6
MKEGSSISVAVRVRPFTEREKGLLAETPKSKEFLGDGSLAVSNTSSNTFCTNGIRKIVRVLDDNVLIFDPPEENPLAKVQKSLLPAGKRFRDVRYAFDRLFGEEASQEDVYKGTTEPLLDSVLQGYNATVFAYGATGCGKTHTISGRPDDPGIIFLTMRALLDRVEGLKRTMNVDISVSYLEIYNEKIRDLLVQDPLSMEKPKSLNICEDAEQNVSVPGLSYFTPTNLEEVMEIIIRGNSNRTMSPTEANAVSSRSHAVLQIYITQTPKSGEKQEESESQNSHKVRSVFSFIDLAGSERASATKNRGKRLVEGANINRSLLALGNCINSLCEPRRRQHVPYRDSKLTRLLKFSLGGNCRTCMIVCISPSSEHYDETHNTLKYGNRAKNIKTKVSRNVVSVDRHVSEYVRTIYELRQKVSILQKRIAEESKQLALNKEVRKISSREIKMLDARSMLKNSFDGSRDLQKSLIEHVRTLRRIEDEITLTKMWISIAKESDAMSGHNIKSVETRLAKLYDQRSLITAKVNPEEICKTFQNSISHIVSSFKGEGADMYADMLQDDVDLLKSIIENQILDAKHESETFSSTSRKLIQNLFLLFPLLPGNAIDVNESLARAFDQLVGIVPSEPTIQVPNLIEKGKAPLLSMFEIPRSPSRFKARSPSKAARVLKKPLKKRVRFSEVPTTSSVPPVEIKNKDSKPKVEKSLDKHNMNNDRSFLVPSRDARNSLTSLSLHSNVAKNKSSHSSKWPTHTLSPIITTALKQPVRRISLVSQPLQKTGGTENTPNA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias691-708Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB072925
EMBL· GenBank· DDBJ
BAB69886.1
EMBL· GenBank· DDBJ
Genomic DNA
CU329671
EMBL· GenBank· DDBJ
CAA20063.2
EMBL· GenBank· DDBJ
Genomic DNA
AB027906
EMBL· GenBank· DDBJ
BAA87210.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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