O59710 · ADRO_SCHPO

Function

function

Adrenodoxin reductase transfers electrons from NADPH to adrenodoxin, which is involved in heme A biosynthesis and in iron-sulfur cluster assembly. Involved in the electron transfer to heme A synthase etp1(cd), a heme protein that catalyzes the conversion of heme O to heme A. Required for the de novo synthesis of Fe-S clusters on iron sulfur cluster assembly protein isu1. Involved in electron delivery for Fe-S cluster synthesis. Essential for coenzyme Q biosynthesis. May be involved in the electron transfer required for the hydroxylation reaction performed by coq6. May play a role in cellular and mitochondrial iron homeostasis.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site27FAD (UniProtKB | ChEBI)
Binding site48FAD (UniProtKB | ChEBI)
Binding site56FAD (UniProtKB | ChEBI)
Binding site92FAD (UniProtKB | ChEBI)
Binding site164-167NADP+ (UniProtKB | ChEBI)
Binding site208-209NADP+ (UniProtKB | ChEBI)
Binding site220NADP+ (UniProtKB | ChEBI)
Binding site375FAD (UniProtKB | ChEBI)
Binding site382NADP+ (UniProtKB | ChEBI)
Binding site382-384FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrion
Molecular FunctionFAD binding
Molecular Functionferredoxin-NAD+ reductase activity
Molecular Functionferredoxin-NADP+ reductase activity
Molecular Functionoxidoreductase activity
Biological Process[2Fe-2S] cluster assembly
Biological Processubiquinone biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable NADPH:adrenodoxin oxidoreductase, mitochondrial
  • EC number
  • Short names
    AR; Adrenodoxin reductase
  • Alternative names
    • Ferredoxin--NADP(+) reductase (Ferredoxin reductase)

Gene names

    • Name
      arh1
    • ORF names
      SPBC3B8.01c

Organism names

Accessions

  • Primary accession
    O59710

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for transit peptide, chain.

TypeIDPosition(s)Description
Transit peptide1-38Mitochondrion
ChainPRO_000033725939-469Probable NADPH:adrenodoxin oxidoreductase, mitochondrial

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    469
  • Mass (Da)
    52,716
  • Last updated
    1998-08-01 v1
  • Checksum
    2AFBDBCF86C57291
MLSRFIKRTYSTQTSSPVVGIIGSGPAAFYTAHRLLRNDPNVKIDMFESRPVPFGLVRYGVAPDHPEVKHVEHKFSEIAESTQFRFLGNVNVGTDVSLRDLTKNYDCLVLAYGAAGDKRLGIPGEDLSGVYSAREVVGWYNSDPRNQNLELDLSQVEDAVVIGHGNVSLDVARILLSNPAQLSPTDINPLFLKSLERSNLKRLHIVGRRNIFSVSFTIKELRELFALSSAVFFAPSFNYSTKWMNETDASGLDRPRKRLLKLLVSEIQKAVSEKRVAPYSKDKKCWNLEFGLTPVEILGHKGNVENVRFQITDSIRTDAESKFTTIPAQLFIRSIGYKSMPLPGMKDVGVPFDDAKGIVKNVNGFVRPGIYTSGWVKHGPIGVIATTMMDAFATADTITKDWKSKKEFLKNSKLGWDGLKKNIKTPVIHWKDWKVIRNAEIERGLRHESLSEKFRSNEDMIKLIYPGKK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CU329671
EMBL· GenBank· DDBJ
CAA18290.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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