O59710 · ADRO_SCHPO
- ProteinProbable NADPH:adrenodoxin oxidoreductase, mitochondrial
- Genearh1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids469 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Adrenodoxin reductase transfers electrons from NADPH to adrenodoxin, which is involved in heme A biosynthesis and in iron-sulfur cluster assembly. Involved in the electron transfer to heme A synthase etp1(cd), a heme protein that catalyzes the conversion of heme O to heme A. Required for the de novo synthesis of Fe-S clusters on iron sulfur cluster assembly protein isu1. Involved in electron delivery for Fe-S cluster synthesis. Essential for coenzyme Q biosynthesis. May be involved in the electron transfer required for the hydroxylation reaction performed by coq6. May play a role in cellular and mitochondrial iron homeostasis.
Catalytic activity
- H+ + NADP+ + 2 reduced [adrenodoxin] = NADPH + 2 oxidized [adrenodoxin]
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 27 | FAD (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 48 | FAD (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 56 | FAD (UniProtKB | ChEBI) | ||||
Sequence: L | ||||||
Binding site | 92 | FAD (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 164-167 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: HGNV | ||||||
Binding site | 208-209 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: RR | ||||||
Binding site | 220 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 375 | FAD (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 382 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 382-384 | FAD (UniProtKB | ChEBI) | ||||
Sequence: GVI |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrion | |
Molecular Function | FAD binding | |
Molecular Function | ferredoxin-NAD+ reductase activity | |
Molecular Function | ferredoxin-NADP+ reductase activity | |
Molecular Function | oxidoreductase activity | |
Biological Process | [2Fe-2S] cluster assembly | |
Biological Process | ubiquinone biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable NADPH:adrenodoxin oxidoreductase, mitochondrial
- EC number
- Short namesAR; Adrenodoxin reductase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Taphrinomycotina > Schizosaccharomycetes > Schizosaccharomycetales > Schizosaccharomycetaceae > Schizosaccharomyces
Accessions
- Primary accessionO59710
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-38 | Mitochondrion | ||||
Sequence: MLSRFIKRTYSTQTSSPVVGIIGSGPAAFYTAHRLLRN | ||||||
Chain | PRO_0000337259 | 39-469 | Probable NADPH:adrenodoxin oxidoreductase, mitochondrial | |||
Sequence: DPNVKIDMFESRPVPFGLVRYGVAPDHPEVKHVEHKFSEIAESTQFRFLGNVNVGTDVSLRDLTKNYDCLVLAYGAAGDKRLGIPGEDLSGVYSAREVVGWYNSDPRNQNLELDLSQVEDAVVIGHGNVSLDVARILLSNPAQLSPTDINPLFLKSLERSNLKRLHIVGRRNIFSVSFTIKELRELFALSSAVFFAPSFNYSTKWMNETDASGLDRPRKRLLKLLVSEIQKAVSEKRVAPYSKDKKCWNLEFGLTPVEILGHKGNVENVRFQITDSIRTDAESKFTTIPAQLFIRSIGYKSMPLPGMKDVGVPFDDAKGIVKNVNGFVRPGIYTSGWVKHGPIGVIATTMMDAFATADTITKDWKSKKEFLKNSKLGWDGLKKNIKTPVIHWKDWKVIRNAEIERGLRHESLSEKFRSNEDMIKLIYPGKK |
Proteomic databases
PTM databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length469
- Mass (Da)52,716
- Last updated1998-08-01 v1
- Checksum2AFBDBCF86C57291
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CU329671 EMBL· GenBank· DDBJ | CAA18290.1 EMBL· GenBank· DDBJ | Genomic DNA |