O58885 · PEPQ_PYRHO
- ProteinXaa-Pro dipeptidase
- GenepepQ
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids351 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position.
Catalytic activity
- H2O + Xaa-L-Pro dipeptide = an L-alpha-amino acid + L-proline
Cofactor
Note: Binds 2 cobalt ions per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 212 | Co2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 223 | Co2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 223 | Co2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 287 | Co2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 316 | Co2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 330 | Co2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 330 | Co2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | metal ion binding | |
Molecular Function | metallopeptidase activity | |
Molecular Function | proline dipeptidase activity | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameXaa-Pro dipeptidase
- EC number
- Short namesX-Pro dipeptidase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Thermococci > Thermococcales > Thermococcaceae > Pyrococcus
Accessions
- Primary accessionO58885
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000185094 | 1-351 | Xaa-Pro dipeptidase | |||
Sequence: MDIMNEKVKKIIEFMDKNSIDAVLIAKNPNVYYISGASPLAGGYILITGESATLYVPELEYEMAKEESNIPVEKFKKMDEFYKALEGIKSLGIESSLPYGFIEELKKKANIKEFKKVDDVIRDMRIIKSEKEIKIIEKACEIADKAVMAAIEEITEGKKEREVAAKVEYLMKMNGAEKPAFDTIIASGYRSALPHGVASDKRIERGDLVVIDLGALYQHYNSDITRTIVVGSPNEKQKEIYEIVLEAQKKAVESAKPGITAKELDSIARNIIAEYGYGEYFNHSLGHGVGLEVHEWPRVSQYDETVLREGMVITIEPGIYIPKIGGVRIEDTILITKNGSKRLTKTERELI |
Interaction
Structure
Sequence
- Sequence statusComplete
- Length351
- Mass (Da)39,401
- Last updated1998-08-01 v1
- Checksum38CB76FFFB766A7E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BA000001 EMBL· GenBank· DDBJ | BAA30249.1 EMBL· GenBank· DDBJ | Genomic DNA |