O57606 · THA_NECMA

Function

function

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Features

Showing features for dna binding, binding site.

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TypeIDPosition(s)Description
DNA binding48-125Nuclear receptor
Binding site51Zn2+ 1 (UniProtKB | ChEBI)
Binding site54Zn2+ 1 (UniProtKB | ChEBI)
Binding site68Zn2+ 1 (UniProtKB | ChEBI)
Binding site71Zn2+ 1 (UniProtKB | ChEBI)
Binding site89Zn2+ 2 (UniProtKB | ChEBI)
Binding site95Zn2+ 2 (UniProtKB | ChEBI)
Binding site105Zn2+ 2 (UniProtKB | ChEBI)
Binding site108Zn2+ 2 (UniProtKB | ChEBI)
Binding site2263,3',5-triiodo-L-thyronine (UniProtKB | ChEBI)
Binding site2753,3',5-triiodo-L-thyronine (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Functionnuclear receptor activity
Molecular Functionsequence-specific DNA binding
Molecular Functionthyroid hormone binding
Molecular Functionzinc ion binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Thyroid hormone receptor alpha
  • Alternative names
    • Nuclear receptor subfamily 1 group A member 1

Gene names

    • Name
      THRA
    • Synonyms
      NR1A1

Organism names

Accessions

  • Primary accession
    O57606

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000534411-408Thyroid hormone receptor alpha

Expression

Tissue specificity

A high level expression seen in the gills, intestine and muscles.

Structure

Family & Domains

Features

Showing features for region, zinc finger, domain.

TypeIDPosition(s)Description
Region1-50Modulating
Zinc finger51-71NR C4-type
Zinc finger89-113NR C4-type
Domain161-405NR LBD

Domain

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    408
  • Mass (Da)
    46,922
  • Last updated
    2005-01-04 v2
  • Checksum
    F5A1A2272595AE9E
MDQNLSDLDCLSDPDEKRWLDGKRKRKNSQCLLKNSMSGYIPSYLDKDEPCVVCSDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYDACCIIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEENRERRRKEEMLKSMQNRPEPTSEEWELIRLVTDAHCSTNAQGSHWKQKRKFLPDAIGQCPMTAVPENDRVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLSGEMAVKREQLKNGGLGVVSDAIFDLGKSLSAFNLDDTEVALLQAVLLMSSDRSGLTCMDKVEKCQETYLLAFEHYINHRKHHIPHFWPKLLMKVTDLRMIGACHASRFMHMKVECPTELFPPLFLEVFEDQEV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Y16623
EMBL· GenBank· DDBJ
CAA76327.2
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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