O57380 · ADH8_PELPE
- ProteinNADP-dependent alcohol dehydrogenase
- GeneADH8
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids373 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- a primary alcohol + NADP+ = an aldehyde + NADPH + H+
Cofactor
Note: Binds 2 Zn2+ ions per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 47 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 68 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 98 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 101 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 104 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 112 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 174 | Zn2+ 1 (UniProtKB | ChEBI); catalytic | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | alcohol dehydrogenase (NADP+) activity | |
Molecular Function | all-trans-retinol dehydrogenase (NAD+) activity | |
Molecular Function | zinc ion binding | |
Biological Process | retinoic acid metabolic process | |
Biological Process | retinol metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNADP-dependent alcohol dehydrogenase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Neobatrachia > Ranoidea > Ranidae > Pelophylax
Accessions
- Primary accessionO57380
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Initiator methionine | 1 | Removed | |||
Modified residue | 2 | N-acetylcysteine | |||
Chain | PRO_0000160756 | 2-373 | NADP-dependent alcohol dehydrogenase | ||
Keywords
- PTM
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Sequence similarities
Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length373
- Mass (Da)39,168
- Last updated2007-01-23 v3
- Checksum954A502267E8DE49
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 74 | in Ref. 1; AA sequence | |||
Sequence conflict | 134 | in Ref. 1; AA sequence | |||
Sequence conflict | 142 | in Ref. 1; AA sequence | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ002554 EMBL· GenBank· DDBJ | CAA05553.1 EMBL· GenBank· DDBJ | mRNA |