O55777 · V_HENDH

Function

function

Plays an essential role in the inhibition of host immune response. Prevents the establishment of cellular antiviral state by blocking interferon-alpha/beta (IFN-alpha/beta) production and signaling pathway. Interacts with host IFIH1/MDA5 and DHX58/LGP2 to inhibit the transduction pathway involved in the activation of IFN-beta promoter, thus protecting the virus against cell antiviral state. Blocks the type I interferon signaling pathway by interacting with host STAT1 and STAT2 and thereby inhibiting their phosphorylation and subsequent nuclear translocation. Efficiently blocks the type II interferon signaling pathway (By similarity).

Miscellaneous

The P/V/C gene has two overlapping open reading frames. One encodes the P/V/W proteins and the other the C protein.

Features

Showing features for binding site.

145750100150200250300350400450
TypeIDPosition(s)Description
Binding site406Zn2+ 1 (UniProtKB | ChEBI)
Binding site425Zn2+ 1 (UniProtKB | ChEBI)
Binding site429Zn2+ 2 (UniProtKB | ChEBI)
Binding site441Zn2+ 2 (UniProtKB | ChEBI)
Binding site443Zn2+ 2 (UniProtKB | ChEBI)
Binding site446Zn2+ 2 (UniProtKB | ChEBI)
Binding site450Zn2+ 1 (UniProtKB | ChEBI)
Binding site453Zn2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componenthost cell
Cellular Componenthost cell cytoplasm
Molecular Functionimportin-alpha family protein binding
Molecular Functionmetal ion binding
Molecular Functionsmall GTPase binding
Biological Processintracellular transport of virus
Biological Processresponse to leptomycin B
Biological Processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
Biological Processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity
Biological Processsymbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity
Biological Processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Non-structural protein V

Gene names

    • Name
      P/V/C

Organism names

Accessions

  • Primary accession
    O55777

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00002360141-457Non-structural protein V
Modified residue257Phosphoserine; by host
Modified residue350Phosphoserine; by host

Keywords

Interaction

Subunit

Interacts with host IFIH1/MDA5, DHX58/LGP2, STAT1 and STAT2.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region26-104Disordered
Compositional bias73-94Polar residues
Region193-403Disordered
Compositional bias293-314Basic and acidic residues
Compositional bias340-354Basic and acidic residues
Compositional bias360-377Polar residues

Sequence similarities

Belongs to the paramyxoviruses V protein family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    457
  • Mass (Da)
    50,648
  • Last updated
    1998-06-01 v1
  • Checksum
    15C63B4FF638587D
MDKLDLVNDGLDIIDFIQKNQKEIQKTYGRSSIQQPSTKDRTRAWEDFLQSTSGEHEQAEGGMPKNDGGTEGRNVEDLSSVTSSDGTIGQRVSNTRAWAEDPDDIQLDPMVTDVVYHDHGGECTGHGPSSSPERGWSYHMSGTHDGNVRAVPDTKVLPNAPKTTVPEEVREIDLIGLEDKFASAGLNPAAVPFVPKNQSTPTEEPPVIPEYYYGSGRRGDLSKSPPRGNVNLDSIKIYTSDDEDENQLEYEDEFAKSSSEVVIDTTPEDNDSINQEEVVGDPSDQGLEHPFPLGKFPEKEETPDVRRKDSLMQDSCKRGGVPKRLPMLSEEFECSGSDDPIIQELEREGSHPGGSLRLREPPQSSGNSRNQPDRQLKTGDAASPGGVQRPGTPMPKSRIMPIKKGHRREVSICWDGRRAWVEEWCNPVCSRITPQPRKQECYCGECPTECSQCCHEE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias73-94Polar residues
Compositional bias293-314Basic and acidic residues
Compositional bias340-354Basic and acidic residues
Compositional bias360-377Polar residues

RNA Editing

Edited at position 407
Partially edited. RNA editing at this position consists of an insertion of one or two guanine nucleotides. The sequence displayed here is the V protein, derived from the +1G edited RNA. The unedited RNA gives rise to the P protein (AC O55778), the +2G edited RNA gives rise to the W protein (AC P0C1C6)

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF010304
EMBL· GenBank· DDBJ
AAC04241.1
EMBL· GenBank· DDBJ
mRNA
AF017149
EMBL· GenBank· DDBJ
AAC83189.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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