O55162 · LYPD3_RAT

  • Protein
    Ly6/PLAUR domain-containing protein 3
  • Gene
    Lypd3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Supports cell migration. May be involved in tumor progression.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentplasma membrane
Cellular Componentside of membrane
Molecular Functionlaminin binding
Biological Processcell-matrix adhesion
Biological Processnegative regulation of smooth muscle cell apoptotic process

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ly6/PLAUR domain-containing protein 3
  • Alternative names
    • GPI-anchored metastasis-associated protein C4.4A

Gene names

    • Name
      Lypd3
    • Synonyms
      C4.4a

Organism names

  • Taxonomic identifier
  • Strain
    • BDIX
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    O55162

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, lipidation, propeptide.

Type
IDPosition(s)Description
Signal1-32
ChainPRO_000022675533-330Ly6/PLAUR domain-containing protein 3
Glycosylation120N-linked (GlcNAc...) asparagine
Glycosylation131N-linked (GlcNAc...) asparagine
Glycosylation178N-linked (GlcNAc...) asparagine
Glycosylation185N-linked (GlcNAc...) asparagine
Lipidation330GPI-anchor amidated glycine
PropeptidePRO_0000226756331-352Removed in mature form

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Found predominantly on the basal layers of squamous epithelium. Expressed in the gravid uterus and on epithelial of the upper gastrointestinal tract. It has been found in tumor lines which metastasize via the lymphatic system.

Gene expression databases

Interaction

Subunit

Interacts with AGR2 and AGR3 (By similarity).
Binds laminin-1 and laminin-5. Interacts with LGALS3

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain35-128UPAR/Ly6 1
Domain142-224UPAR/Ly6 2
Region236-330Disordered
Compositional bias252-285Polar residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    352
  • Mass (Da)
    36,961
  • Last updated
    1998-06-01 v1
  • Checksum
    1894500CFCF9CAF5
MDAARRGDTQPVMWTTRWLLLLPLLLCEGAQALECYSCVQKADDGCSPHKMKTVKCGPGVDVCTEAVGAVESIHGQFSVAVRGCGSGIPGKNDRGLDLHGLLAFIQLQQCTEDRCNAKLNLTLRGLNPAGNESAYEHNGAECYSCMGLSREKCQGAMPPVVNCYNASGRVYKGCFDGNVTLTAANVTVSLPVRGCVQDEACTRDGVTGPGFTLSGSCCQGPRCNSDLRNKTYFSPRIPPLVLLPPPTTPAPSTRTQNSSSTTSTTAPTTATTTIKPTTVQASHTSSTHETEHEVIQEEGSHLSGGATGHQDRSNMGKFPEKGGAQIPSKGGSDALGSWLSAILLTVVAGAML

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias252-285Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ001043
EMBL· GenBank· DDBJ
CAA04497.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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