O55112 · AFF2_MOUSE

  • Protein
    AF4/FMR2 family member 2
  • Gene
    Aff2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnuclear speck
Cellular Componentnucleus
Molecular FunctionG-quadruplex RNA binding
Biological Processlearning or memory
Biological ProcessmRNA processing
Biological Processnegative regulation of gene expression
Biological Processnuclear speck organization
Biological Processregulation of gene expression
Biological Processregulation of RNA splicing
Biological ProcessRNA splicing

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    AF4/FMR2 family member 2
  • Alternative names
    • Protein FMR-2 (FMR2P)
    • Protein Ox19

Gene names

    • Name
      Aff2
    • Synonyms
      Fmr2, Ox19

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O55112
  • Secondary accessions
    • B1ATW0

Proteomes

Organism-specific databases

Subcellular Location

Nucleus speckle
Note: When splicing or transcription are inhibited, accumulates in large, rounded speckles and in the nucleolus.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002159131-1272AF4/FMR2 family member 2
Modified residue395Phosphoserine
Modified residue482Phosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in the hippocampus, the piriform cortex, Purkinje cells and the cingulate gyrus.

Developmental stage

Expressed before day 7 in the embryo and reached its highest levels at 10.5-11.5 days. In the embryo at day 11, expression is more specific in the roof of the hind brain and the lateral ventricle of the brain.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region151-190Disordered
Compositional bias162-190Polar residues
Region204-231Disordered
Compositional bias206-231Polar residues
Region372-401Disordered
Compositional bias384-401Basic and acidic residues
Region422-497Disordered
Compositional bias431-477Polar residues
Compositional bias557-578Basic and acidic residues
Region557-694Disordered
Compositional bias591-605Basic and acidic residues
Compositional bias607-623Polar residues
Compositional bias626-678Basic and acidic residues
Compositional bias679-693Polar residues
Compositional bias715-738Polar residues
Region715-743Disordered
Region772-899Disordered
Compositional bias810-831Basic and acidic residues
Compositional bias853-870Basic and acidic residues

Sequence similarities

Belongs to the AF4 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,272
  • Mass (Da)
    140,181
  • Last updated
    2010-02-09 v2
  • Checksum
    1CE41F1AEFE9C2B4
MDLFDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEEDLFSSGFDLFGEPYKVAEYTNKGDALANRVQNTLGSYDEMKDLLSNHSSQNHLVGIPKNSAPQTPISKSEASFYPEQKNRMIPSHQETTHSSTPMPPPSVVILNSTLIHSNRKSKSEWPRDSHNTSPAQASQTSSQPNKMQTSTQDPPQTRLEDFFVYPAEQPQIGTVEKSNPSSKEENNPNSGGEDTFKEIFQSNSPEESEFTVQAPGSPLVASSLLAPSSGLSVPTFPPGLYCKTSMGQQKPTAYVRPMDGQDQATDISPTLKPSIEFENSFGNLSFGSLLDGKPSAVSSKTKLPKFTILQTSEVSLTSDPSCVEEILRESQHLTPGFTLQKWSDPSSRASTKMLEDDLKLSSDEDDLEPVKTLTTQCTANELYQAVEKAKPKNNPVNPLLATPQSTPATQTNVGSGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPTETISLPPPIIQPVEVQVKVKPNPSQAVAVPKERPLLSLIREKARPRPTQKTPETKALKHKLSTSVDTVSQRTIGKKQPKKVEKNTSFEEFTWPKPNITNSTPKEKGSVELPDPPRSRNKATAHKPVPRKEPRPHVPLATEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPPCITSKSKETSNASLTLSTLTNGNSNNLSTSNEETAFSPPPAMQTELLSPLRDHENPKNLWVKIDLDLLSRVPGQNSVPVTPAKTDYKETASKPKRQTAATAVEKPAPKGKRKHKPAETAEKIPEKKQRLEDNTTICLLPPCISPAPPHKPPSTRENSSRRANRKKEEKLFPPALSPLAEDPPRRRNVSGNNGHFGQDKNISMAGQITSSKPKRSEGKFCATFKGISINEGDAPKKAASATVTVANMALATATATATVPAIVTATVTATATTTATATTTTTTTTISSITPTITSGLMDSSHLEMTSWAALPLLSSSSANVRRPKLTFDDSVHNADFYMQEAKKLKHKADALFEKFGKAVNYADAALSFTECGNAMERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLRMFKLKKDHAMKYSRSLMEYFKQNASKVTQIPSPWVGNGKNTPSPVSLNNVSPINSVGNCNNGPVTIPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRDNKEFFGDLDTLMGPLTQHSSMTNLVRYVRQGLCWLRIDAHLL

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias162-190Polar residues
Compositional bias206-231Polar residues
Compositional bias384-401Basic and acidic residues
Compositional bias431-477Polar residues
Sequence conflict432in Ref. 1; CAA04821
Sequence conflict544in Ref. 1; CAA04821
Compositional bias557-578Basic and acidic residues
Compositional bias591-605Basic and acidic residues
Compositional bias607-623Polar residues
Compositional bias626-678Basic and acidic residues
Compositional bias679-693Polar residues
Compositional bias715-738Polar residues
Compositional bias810-831Basic and acidic residues
Compositional bias853-870Basic and acidic residues
Sequence conflict941in Ref. 1; CAA04821

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ001549
EMBL· GenBank· DDBJ
CAA04821.1
EMBL· GenBank· DDBJ
mRNA
AL663113
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL672120
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL808131
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BX294655
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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