O55087 · MEF2B_MOUSE

  • Protein
    Myocyte-specific enhancer factor 2B
  • Gene
    Mef2b
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT]4TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription.

Features

Showing features for dna binding.

134950100150200250300
TypeIDPosition(s)Description
DNA binding58-86Mef2-type

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionhistone deacetylase binding
Molecular Functionprotein dimerization activity
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of DNA-templated transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Myocyte-specific enhancer factor 2B

Gene names

    • Name
      Mef2b

Organism names

  • Taxonomic identifier
  • Strain
    • 129/Sv
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O55087
  • Secondary accessions
    • O55088
    • O55089
    • O55090
    • O55231
    • Q61843

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001994321-349Myocyte-specific enhancer factor 2B

Proteomic databases

PTM databases

Expression

Tissue specificity

Highest expression found in embryonic heart and skeletal muscle. Low levels found in adult spleen, lung and testis while no expression is found in adult heart, brain or skeletal muscle.

Developmental stage

Higher expression in early embryo than in adult.

Interaction

Subunit

Heterodimer. Interacts with HDAC9 (By similarity).
Interacts with HDAC7

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain3-57MADS-box
Region237-317Disordered
Region330-349Disordered

Sequence similarities

Belongs to the MEF2 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

O55087-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    B-1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    349
  • Mass (Da)
    37,435
  • Last updated
    1998-06-01 v1
  • Checksum
    4C49E2A2A8D493D8
MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCDIALIIFNSAQRLFQYASSDMDRVLLKYTEYSEPHESRTNADILQTLKRRGVGLDGPELDMEEGPEGPGEKLLRTLGGDRGSASPRPRIYPVAPAMSVSELSYRVPPATPGCDPGGLGEVPSVHSRPAYFRPPGLGHPIFSPSHLASKTPPPLYLATDGRRPDLPPGLVGARGGLGTSRSLYSGLQSPGAPGPALGSFAFLPSGSTDCSPGDAAQGPLQPSPWPPTRDAVDPARPVARSLCKEGPPSRGASPPTPPVSIKSERLSPVTGTSGDFPRSFPYPLLLARPLAEPLRPSASLHRLTPDSWPR

O55087-2

  • Name
    B-2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

O55087-3

  • Name
    B-3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 220-242: RSLYSGLQSPGAPGPALGSFAFL → IAARETQLRDPCNPHPGHQRGTL
    • 243-349: Missing

O55087-4

  • Name
    B-4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 210-232: VGARGGLGTSRSLYSGLQSPGAP → IAARETQLRDPCNPHPGHQRGTL
    • 233-349: Missing

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q80VR4Q80VR4_MOUSEMef2b339
K7N7F1K7N7F1_MOUSEMef2b349
E9Q2M6E9Q2M6_MOUSEMef2b242
D3Z372D3Z372_MOUSEMef2b232

Features

Showing features for alternative sequence, sequence conflict.

Type
IDPosition(s)Description
Alternative sequenceVSP_006243210-219in isoform B-2
Alternative sequenceVSP_006244210-232in isoform B-4
Alternative sequenceVSP_006245220-242in isoform B-3
Alternative sequenceVSP_006246233-349in isoform B-4
Alternative sequenceVSP_006247243-349in isoform B-3
Sequence conflict291in Ref. 3; BAA24542/BAA24544

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D50311
EMBL· GenBank· DDBJ
BAA08850.1
EMBL· GenBank· DDBJ
mRNA
D87831
EMBL· GenBank· DDBJ
BAA24539.1
EMBL· GenBank· DDBJ
Genomic DNA
D87831
EMBL· GenBank· DDBJ
BAA24540.1
EMBL· GenBank· DDBJ
Genomic DNA
D87831
EMBL· GenBank· DDBJ
BAA24541.1
EMBL· GenBank· DDBJ
Genomic DNA
D87835
EMBL· GenBank· DDBJ
BAA24544.1
EMBL· GenBank· DDBJ
mRNA
D87836
EMBL· GenBank· DDBJ
BAA24545.1
EMBL· GenBank· DDBJ
mRNA
D87834
EMBL· GenBank· DDBJ
BAA24543.1
EMBL· GenBank· DDBJ
mRNA
D87833
EMBL· GenBank· DDBJ
BAA24542.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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