O55026 · ENTP2_MOUSE

  • Protein
    Ectonucleoside triphosphate diphosphohydrolase 2
  • Gene
    Entpd2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent (By similarity).

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for active site, binding site.

149550100150200250300350400450
TypeIDPosition(s)Description
Active site165Proton acceptor
Binding site204-208ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentbasement membrane
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionnucleoside diphosphate phosphatase activity
Molecular Functionribonucleoside triphosphate phosphatase activity
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processplatelet activation
Biological Processpurine ribonucleoside diphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ectonucleoside triphosphate diphosphohydrolase 2
  • EC number
  • Short names
    NTPDase 2
  • Alternative names
    • CD39 antigen-like 1
    • Ecto-ATP diphosphohydrolase 2 (Ecto-ATPDase 2; Ecto-ATPase 2)

Gene names

    • Name
      Entpd2
    • Synonyms
      Cd39l1

Organism names

  • Taxonomic identifier
  • Strains
    • CD-1
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O55026
  • Secondary accessions
    • O35928
    • Q9DCR9

Proteomes

Organism-specific databases

Subcellular Location

Isoform Long

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-4Cytoplasmic
Transmembrane5-25Helical
Topological domain26-462Extracellular
Transmembrane463-483Helical
Topological domain484-495Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00002099071-495Ectonucleoside triphosphate diphosphohydrolase 2
Glycosylation64N-linked (GlcNAc...) asparagine
Disulfide bond75↔99
Glycosylation129N-linked (GlcNAc...) asparagine
Disulfide bond242↔284
Disulfide bond265↔310
Glycosylation294N-linked (GlcNAc...) asparagine
Glycosylation319N-linked (GlcNAc...) asparagine
Disulfide bond323↔328
Disulfide bond377↔399
Glycosylation378N-linked (GlcNAc...) asparagine
Glycosylation443N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Induction

By dioxin.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the GDA1/CD39 NTPase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

O55026-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    Long
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    495
  • Mass (Da)
    54,319
  • Last updated
    2004-03-15 v2
  • Checksum
    A76468A0CBF86AAC
MAGKLVSLVPPLLLAAVGLAGLLLLCVPTQDVREPPALKYGIVLDAGSSHTSMFVYKWPADKENDTGIVGQHSSCDVRGGGISSYANDPSRAGQSLVECLEQALRDVPKDRYASTPLYLGATAGMRLLNLTSPEATAKVLEAVTQTLTRYPFDFRGARILSGQDEGVFGWVTANYLLENFIKYGWVGRWIRPRKGTLGAMDLGGASTQITFETTSPSEDPDNEVHLRLYGQHYRVYTHSFLCYGRDQVLQRLLASALQIHRFHPCWPKGYSTQVLLREVYQSPCTMGQRPQTFNSSATVSLSGTSNAALCRDLVSGLFNISSCPFSQCSFNGVFQPPVAGNFIAFSAFYYTVDFLKTVMGLPVGTLKQLEDATETTCNQTWAELQARVPGQQTRLPDYCAVAMFIHQLLSRGYRFDERSFRGVVFEKKAADTAVGWALGYMLNLTNLIPADLPGLRKGTHFSSWVALLLLFTVLILAALVLLLRQVRSAKSPGAL

O55026-2

  • Name
    Short
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_003611130-132in isoform Short
Alternative sequenceVSP_003612133-495in isoform Short
Sequence conflict400in Ref. 2; AAC24347
Sequence conflict414in Ref. 2; AAC24347
Sequence conflict437in Ref. 2; AAC24347

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U91511
EMBL· GenBank· DDBJ
AAB81014.1
EMBL· GenBank· DDBJ
mRNA
AF042811
EMBL· GenBank· DDBJ
AAC24347.1
EMBL· GenBank· DDBJ
mRNA
AY376711
EMBL· GenBank· DDBJ
AAQ86586.1
EMBL· GenBank· DDBJ
mRNA
AK002553
EMBL· GenBank· DDBJ
BAB22182.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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