Lithium affects the phosphatidylinositol signaling system in two ways: depleting inositol consequently decreasing phosphoinositides; elevating inositol monophosphate levels followed by phosphoinositols accumulation. Each or both may mediate lithium-induced behavior
local synthesis of IMPA1 is required for neurotrophin-dependent axon growth; selective regulation of IMPA1 levels in axons may provide a target for the development of new therapeutic strategies for specific neurological and psychiatric diseases
IMPA1-/- mouse represents a novel model to study inositol homeostasis and indicates that genetic inactivation of IMPA1 can mimic some actions of lithium
Results suggest that calbindin D28k acts as an activity-dependent sensor that targets membrane/cytoskeleton-bound myo-inositol monophosphatase in central neurons.
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