O55023 · IMPA1_MOUSE

  • Protein
    Inositol monophosphatase 1
  • Gene
    Impa1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Inhibited by Li+, Ca2+ and Mn2+, but also by Mg2+ at concentrations above 3 mM.

Pathway

Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site70Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site70substrate
Binding site90Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site90Mg2+ 2 (UniProtKB | ChEBI)
Binding site90-95substrate
Binding site92Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site93Mg2+ 2 (UniProtKB | ChEBI)
Binding site194-196substrate
Binding site213substrate
Binding site220Mg2+ 2 (UniProtKB | ChEBI)
Binding site220substrate

GO annotations

AspectTerm
Cellular Componentaxon
Cellular Componentcytoplasm
Cellular Componentneuronal cell body
Molecular Functioninositol monophosphate 1-phosphatase activity
Molecular Functioninositol monophosphate 3-phosphatase activity
Molecular Functioninositol monophosphate 4-phosphatase activity
Molecular Functioninositol monophosphate phosphatase activity
Molecular Functionlithium ion binding
Molecular Functionmagnesium ion binding
Molecular Functionmanganese ion binding
Molecular Functionprotein homodimerization activity
Biological Processinositol biosynthetic process
Biological Processinositol metabolic process
Biological Processphosphatidylinositol biosynthetic process
Biological Processphosphatidylinositol phosphate biosynthetic process
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inositol monophosphatase 1
  • EC number
  • Short names
    IMP 1; IMPase 1
  • Alternative names
    • D-galactose 1-phosphate phosphatase
      (EC:3.1.3.94
      ) . EC:3.1.3.94 (UniProtKB | ENZYME | Rhea)
    • Inositol-1(or 4)-monophosphatase 1
    • Lithium-sensitive myo-inositol monophosphatase A1

Gene names

    • Name
      Impa1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O55023

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001425141-277Inositol monophosphatase 1

Proteomic databases

PTM databases

Expression

Tissue specificity

Mostly expressed in brain, small intestine, testis, kidney, and spleen (at protein level).

Induction

By lithium Li+ in hippocamp.

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    277
  • Mass (Da)
    30,436
  • Last updated
    1998-06-01 v1
  • Checksum
    EDBDB7BD24748E9D
MADPWQECMDYAVILARQAGEMIREALKNEMDVMIKSSPADLVTVTDQKVEKMLMSSIKEKYPCHSFIGEESVAAGEKTVFTESPTWFIDPIDGTTNFVHRFPFVAVSIGFLVNKEMEFGIVYSCVEDKMYTGRKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRKPETLRIVLSNMEKLCSIPIHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDMAGAGIIVTEAGGVLMDVTGGPFDLMSRRIIAANSITLAKRIAKEIEIIPLQRDDES

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0A6YW07A0A0A6YW07_MOUSEImpa1208
Q80ZJ2Q80ZJ2_MOUSEImpa1276
D3Z703D3Z703_MOUSEImpa189
Q924B0Q924B0_MOUSEImpa1277

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF042730
EMBL· GenBank· DDBJ
AAB97469.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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