O55023 · IMPA1_MOUSE
- ProteinInositol monophosphatase 1
- GeneImpa1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids277 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
Catalytic activity
- a myo-inositol phosphate + H2O = myo-inositol + phosphate
Cofactor
Activity regulation
Inhibited by Li+, Ca2+ and Mn2+, but also by Mg2+ at concentrations above 3 mM.
Pathway
Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 70 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: E | ||||||
Binding site | 70 | substrate | ||||
Sequence: E | ||||||
Binding site | 90 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 90 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 90-95 | substrate | ||||
Sequence: DPIDGT | ||||||
Binding site | 92 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: I | ||||||
Binding site | 93 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 194-196 | substrate | ||||
Sequence: GTA | ||||||
Binding site | 213 | substrate | ||||
Sequence: E | ||||||
Binding site | 220 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 220 | substrate | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | cytoplasm | |
Cellular Component | neuronal cell body | |
Molecular Function | inositol monophosphate 1-phosphatase activity | |
Molecular Function | inositol monophosphate 3-phosphatase activity | |
Molecular Function | inositol monophosphate 4-phosphatase activity | |
Molecular Function | inositol monophosphate phosphatase activity | |
Molecular Function | lithium ion binding | |
Molecular Function | magnesium ion binding | |
Molecular Function | manganese ion binding | |
Molecular Function | protein homodimerization activity | |
Biological Process | inositol biosynthetic process | |
Biological Process | inositol metabolic process | |
Biological Process | phosphatidylinositol biosynthetic process | |
Biological Process | phosphatidylinositol phosphate biosynthetic process | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInositol monophosphatase 1
- EC number
- Short namesIMP 1; IMPase 1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionO55023
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000142514 | 1-277 | Inositol monophosphatase 1 | |||
Sequence: MADPWQECMDYAVILARQAGEMIREALKNEMDVMIKSSPADLVTVTDQKVEKMLMSSIKEKYPCHSFIGEESVAAGEKTVFTESPTWFIDPIDGTTNFVHRFPFVAVSIGFLVNKEMEFGIVYSCVEDKMYTGRKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRKPETLRIVLSNMEKLCSIPIHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDMAGAGIIVTEAGGVLMDVTGGPFDLMSRRIIAANSITLAKRIAKEIEIIPLQRDDES |
Proteomic databases
PTM databases
Expression
Tissue specificity
Mostly expressed in brain, small intestine, testis, kidney, and spleen (at protein level).
Induction
By lithium Li+ in hippocamp.
Structure
Sequence
- Sequence statusComplete
- Length277
- Mass (Da)30,436
- Last updated1998-06-01 v1
- ChecksumEDBDB7BD24748E9D
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0A6YW07 | A0A0A6YW07_MOUSE | Impa1 | 208 | ||
Q80ZJ2 | Q80ZJ2_MOUSE | Impa1 | 276 | ||
D3Z703 | D3Z703_MOUSE | Impa1 | 89 | ||
Q924B0 | Q924B0_MOUSE | Impa1 | 277 |
Keywords
- Technical term