O55003 · BNIP3_MOUSE

  • Protein
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
  • Gene
    Bnip3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2 (By similarity).
Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity).
The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity).
Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentdendrite
Cellular Componentendoplasmic reticulum
Cellular Componentmitochondrial membrane
Cellular Componentmitochondrial outer membrane
Cellular Componentmitochondrion
Cellular Componentnuclear envelope
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular Componentpostsynaptic density
Molecular FunctionGTPase binding
Molecular Functionidentical protein binding
Molecular Functionprotein homodimerization activity
Biological Processapoptotic process
Biological Processautophagic cell death
Biological Processbrown fat cell differentiation
Biological Processcardiac muscle cell apoptotic process
Biological Processcellular response to cobalt ion
Biological Processcellular response to hydrogen peroxide
Biological Processcellular response to hypoxia
Biological Processcellular response to mechanical stimulus
Biological Processcerebral cortex development
Biological Processdefense response to virus
Biological Processgranzyme-mediated programmed cell death signaling pathway
Biological Processintrinsic apoptotic signaling pathway
Biological Processintrinsic apoptotic signaling pathway in response to hypoxia
Biological Processmitochondrial fragmentation involved in apoptotic process
Biological Processmitochondrial outer membrane permeabilization
Biological Processmitochondrial protein catabolic process
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of membrane potential
Biological Processnegative regulation of mitochondrial fusion
Biological Processnegative regulation of mitochondrial membrane permeability involved in apoptotic process
Biological Processnegative regulation of mitochondrial membrane potential
Biological Processnegative regulation of programmed cell death
Biological Processnegative regulation of reactive oxygen species metabolic process
Biological Processneuron apoptotic process
Biological Processoligodendrocyte differentiation
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of autophagy of mitochondrion
Biological Processpositive regulation of cardiac muscle cell apoptotic process
Biological Processpositive regulation of macroautophagy
Biological Processpositive regulation of mitochondrial calcium ion concentration
Biological Processpositive regulation of mitochondrial fission
Biological Processpositive regulation of programmed cell death
Biological Processpositive regulation of protein-containing complex disassembly
Biological Processpositive regulation of release of cytochrome c from mitochondria
Biological Processreactive oxygen species metabolic process
Biological Processregulation of aerobic respiration
Biological Processregulation of mitochondrial membrane permeability
Biological Processregulation of mitochondrion organization
Biological Processresponse to axon injury
Biological Processresponse to bacterium
Biological Processresponse to hyperoxia
Biological Processresponse to hypoxia
Biological Processresponse to oxygen-glucose deprivation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Gene names

    • Name
      Bnip3
    • Synonyms
      Nip3

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O55003
  • Secondary accessions
    • Q544Y4

Proteomes

Organism-specific databases

Subcellular Location

Mitochondrion outer membrane
; Single-pass membrane protein
Note: Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane (By similarity).

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane157-177Helical

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000649651-187BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
Modified residue48Phosphoserine
Modified residue60Phosphoserine
Modified residue77Phosphoserine
Modified residue79Phosphoserine
Modified residue85Phosphoserine
Modified residue88Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer. Binds to BCL2. Interacts with BNIP3L and ACAA2. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains). Interacts with BOK; promotes BOK oligomerization.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias, motif.

TypeIDPosition(s)Description
Region42-86Disordered
Compositional bias54-74Polar residues
Motif93-118BH3

Sequence similarities

Belongs to the NIP3 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    187
  • Mass (Da)
    20,978
  • Last updated
    1998-06-01 v1
  • Checksum
    901BCFACF43EE989
MSQSGEENLQGSWVELHFSNGNGSSVPASVSIYNGDMEKILLDAQHESGRSSSKSSHCDSPPRSQTPQDTNRAEIDSHSFGEKNSTLSEEDYIERRREVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMRNTSVMKKGGIFSADFLKVFLPSLLLSHLLAIGLGIYIGRRLTTSTSTF

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1B0GT26A0A1B0GT26_MOUSEBnip3173

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias54-74Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF041054
EMBL· GenBank· DDBJ
AAD02922.1
EMBL· GenBank· DDBJ
mRNA
AK014223
EMBL· GenBank· DDBJ
BAB29214.1
EMBL· GenBank· DDBJ
mRNA
AK075943
EMBL· GenBank· DDBJ
BAC36072.1
EMBL· GenBank· DDBJ
mRNA
AK152610
EMBL· GenBank· DDBJ
BAE31356.1
EMBL· GenBank· DDBJ
mRNA
BC046603
EMBL· GenBank· DDBJ
AAH46603.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp