O54926 · SIVA_MOUSE

  • Protein
    Apoptosis regulatory protein Siva
  • Gene
    Siva1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis (By similarity).

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Isoform 1 binds 3 zinc ions. Isoform 2 binds 2 zinc ions.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleoplasm
Molecular FunctionCD27 receptor binding
Molecular Functionmetal ion binding
Molecular Functiontumor necrosis factor receptor binding
Molecular Functionvirus receptor activity
Biological Processextrinsic apoptotic signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Apoptosis regulatory protein Siva
  • Alternative names
    • CD27-binding protein (CD27BP)

Gene names

    • Name
      Siva1
    • Synonyms
      Siva

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O54926
  • Secondary accessions
    • Q3U6J2
    • Q921I8
    • Q9CWL1
    • Q9R1Q0
    • Q9R1Q1

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Note: In the nucleus, accumulates in dot-like structures.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000977751-175Apoptosis regulatory protein Siva
Modified residue34Phosphotyrosine; by ABL2
Modified residue70Phosphoserine

Post-translational modification

Phosphorylated by ABL2/ARG in response to oxidative stress.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in testis, heart, liver, lung, and muscle, and less in kidney, spleen and brain.

Induction

By p53, camptothecin, stroke injury and infection with coxsackievirus B3. This up-regulation is sufficient to induce apoptosis in neural tissue.

Gene expression databases

Interaction

Subunit

Binds through its N-terminal region to the C-terminus of CD27 and to PXMP2/PMP22. Binds to the C-terminus of TNFRSF18/GITR. Isoform 1 binds to BCL2L1/BCLX isoform Bcl-x(L) but not to BAX.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region36-55Interaction with BCL2L1 isoform Bcl-x(L) and inhibition of BCL2L1 anti-apoptotic activity

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

O54926-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    Siva-1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    175
  • Mass (Da)
    18,770
  • Last updated
    1998-06-01 v1
  • Checksum
    1E132C1580ABE3F2
MPKRSCPFADAAPLQLKVHVGLKELSHGVFAERYSREVFERTKQLLFQGARAYRDHISSEDCSVNHLQESLKSGVVGAPQPARGQMLIGPDGRLTRCQAQASEGGLPRTAPIACSSCMRSVDGKAVCSQCERALCGQCVYTCWGCGALACVLCGLADYADDGEKTLCTSCAMFEA

O54926-2

  • Name
    2
  • Synonyms
    Siva-2
  • Note
    Mouse isoform 2 has been shown to have no pro-apoptotic activity.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict1-15in Ref. 2; BAB27029
Alternative sequenceVSP_00752640-104in isoform 2
Sequence conflict126in Ref. 3; AAH12279
Sequence conflict142in Ref. 1; AAD50060

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF033115
EMBL· GenBank· DDBJ
AAC04706.1
EMBL· GenBank· DDBJ
Genomic DNA
AF033113
EMBL· GenBank· DDBJ
AAD50059.1
EMBL· GenBank· DDBJ
mRNA
AF033112
EMBL· GenBank· DDBJ
AAD50058.1
EMBL· GenBank· DDBJ
mRNA
AF033114
EMBL· GenBank· DDBJ
AAD50060.1
EMBL· GenBank· DDBJ
mRNA
AK010562
EMBL· GenBank· DDBJ
BAB27029.1
EMBL· GenBank· DDBJ
mRNA
AK017570
EMBL· GenBank· DDBJ
BAB30811.1
EMBL· GenBank· DDBJ
mRNA
AK153115
EMBL· GenBank· DDBJ
BAE31732.1
EMBL· GenBank· DDBJ
mRNA
BC012279
EMBL· GenBank· DDBJ
AAH12279.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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