O54926 · SIVA_MOUSE
- ProteinApoptosis regulatory protein Siva
- GeneSiva1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids175 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis (By similarity).
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleoplasm | |
Molecular Function | CD27 receptor binding | |
Molecular Function | metal ion binding | |
Molecular Function | tumor necrosis factor receptor binding | |
Molecular Function | virus receptor activity | |
Biological Process | extrinsic apoptotic signaling pathway |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameApoptosis regulatory protein Siva
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionO54926
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000097775 | 1-175 | Apoptosis regulatory protein Siva | |||
Sequence: MPKRSCPFADAAPLQLKVHVGLKELSHGVFAERYSREVFERTKQLLFQGARAYRDHISSEDCSVNHLQESLKSGVVGAPQPARGQMLIGPDGRLTRCQAQASEGGLPRTAPIACSSCMRSVDGKAVCSQCERALCGQCVYTCWGCGALACVLCGLADYADDGEKTLCTSCAMFEA | ||||||
Modified residue | 34 | Phosphotyrosine; by ABL2 | ||||
Sequence: Y | ||||||
Modified residue | 70 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Phosphorylated by ABL2/ARG in response to oxidative stress.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in testis, heart, liver, lung, and muscle, and less in kidney, spleen and brain.
Induction
By p53, camptothecin, stroke injury and infection with coxsackievirus B3. This up-regulation is sufficient to induce apoptosis in neural tissue.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 36-55 | Interaction with BCL2L1 isoform Bcl-x(L) and inhibition of BCL2L1 anti-apoptotic activity | ||||
Sequence: REVFERTKQLLFQGARAYRD |
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
O54926-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsSiva-1
- Length175
- Mass (Da)18,770
- Last updated1998-06-01 v1
- Checksum1E132C1580ABE3F2
O54926-2
- Name2
- SynonymsSiva-2
- NoteMouse isoform 2 has been shown to have no pro-apoptotic activity.
- Differences from canonical
- 40-104: Missing
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 1-15 | in Ref. 2; BAB27029 | ||||
Sequence: MPKRSCPFADAAPLQ → MAKGRWRLAEAGAVE | ||||||
Alternative sequence | VSP_007526 | 40-104 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 126 | in Ref. 3; AAH12279 | ||||
Sequence: V → A | ||||||
Sequence conflict | 142 | in Ref. 1; AAD50060 | ||||
Sequence: C → S |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF033115 EMBL· GenBank· DDBJ | AAC04706.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF033113 EMBL· GenBank· DDBJ | AAD50059.1 EMBL· GenBank· DDBJ | mRNA | ||
AF033112 EMBL· GenBank· DDBJ | AAD50058.1 EMBL· GenBank· DDBJ | mRNA | ||
AF033114 EMBL· GenBank· DDBJ | AAD50060.1 EMBL· GenBank· DDBJ | mRNA | ||
AK010562 EMBL· GenBank· DDBJ | BAB27029.1 EMBL· GenBank· DDBJ | mRNA | ||
AK017570 EMBL· GenBank· DDBJ | BAB30811.1 EMBL· GenBank· DDBJ | mRNA | ||
AK153115 EMBL· GenBank· DDBJ | BAE31732.1 EMBL· GenBank· DDBJ | mRNA | ||
BC012279 EMBL· GenBank· DDBJ | AAH12279.1 EMBL· GenBank· DDBJ | mRNA |