O54824 · IL16_MOUSE

  • Protein
    Pro-interleukin-16
  • Gene
    Il16
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.
Isoform 2 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcollagen-containing extracellular matrix
Cellular Componentcytosol
Cellular Componentextracellular space
Cellular ComponentFlemming body
Cellular Componentfocal adhesion
Cellular Componentnuclear speck
Cellular Componentplasma membrane
Molecular FunctionCD4 receptor binding
Molecular Functioncytokine activity
Biological Processinduction of positive chemotaxis
Biological Processleukocyte chemotaxis
Biological Processpositive regulation of inflammatory response
Biological Processpositive regulation of interleukin-1 alpha production
Biological Processpositive regulation of interleukin-12 production
Biological Processpositive regulation of interleukin-6 production
Biological Processregulation of calcium ion transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pro-interleukin-16
  • Cleaved into 1 chains
    • Interleukin-16 (IL-16) Alternative names: Lymphocyte chemoattractant factor (LCF)

Gene names

    • Name
      Il16

Organism names

  • Taxonomic identifier
  • Strains
    • NFS
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    O54824
  • Secondary accessions
    • O70236
    • Q3TEM4
    • Q5DTR5
    • Q8R0G5
    • Q9QZP6

Proteomes

Organism-specific databases

Subcellular Location

Secreted

Isoform 1

Cytoplasm
Note: Colocalizes with GRIN2C in neuronal cell bodies and neurites.

Isoform 2

Nucleus

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00003775461-1322Pro-interleukin-16
Modified residue917Phosphoserine
ChainPRO_00000154181205-1322Interleukin-16

Post-translational modification

Synthesized as a chemo-attractant inactive precursor which is proteolytically cleaved by caspase-3 to yield IL-16.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Isoform 1 is expressed in neurons of the cerebellum and hippocampus. Isoform 2 is expressed in thymus, spleen and lung.

Gene expression databases

Interaction

Subunit

Homotetramer (Probable). Isoform 2 interacts with GRIN2A. Isoform 1 interacts with GRIN2D, KCNJ10, KCNJ15 and CACNA1C. Isoform 2 interacts (via PDZ 3 domain) with PPP1R12A, PPP1R12B and PPP1R12C. Isoform 1 interacts with PPP1R12B. Isoform 3 interacts with GABPB1. Isoform 2 interacts (via PDZ 3 domain) with HDAC3 (By similarity).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY O54824Itpkc Q7TS723EBI-641708, EBI-648015

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias104-146Polar residues
Region104-147Disordered
Region183-449Interaction with GRIN2A
Domain213-299PDZ 1
Domain352-437PDZ 2
Compositional bias480-497Basic and acidic residues
Region480-633Disordered
Compositional bias505-519Polar residues
Compositional bias531-545Polar residues
Compositional bias568-588Basic and acidic residues
Compositional bias600-623Basic and acidic residues
Region651-695Disordered
Compositional bias660-682Polar residues
Compositional bias729-745Polar residues
Region729-963Disordered
Compositional bias825-868Polar residues
Compositional bias887-908Polar residues
Compositional bias935-949Polar residues
Region1099-1195Interaction with PPP1R12A, PPP1R12B and PPP1R12C
Domain1105-1190PDZ 3
Domain1226-1309PDZ 4

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative promoter usage.

O54824-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    NIL-16
  • Note
    Produced by alternative promoter usage. Is probably proteolytically processed to yield IL-16.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    1,322
  • Mass (Da)
    141,435
  • Last updated
    2009-06-16 v3
  • Checksum
    DDB94003A5DCB738
MEPHGHSGKSRKSTKFRSISRSLILCNAKTSDDGSSPDEKYPDPFETSLCQGKEGFFHSSMQLADTFEAGLSNIPDLALASDSAQLAAAGSDRGKHCRKMFFMKESSSTSSKEKSGKPEAQSSSFLFPKACHQRTRSNSTSVNPYSAGEIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQLDYPILGTARPTRSLSTAQLGQLSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKSIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTTPPSLCSHLSPPLCRSLSSSTCGAQDSSPFSLESPASPASTAKPNYRIMVEVSLKKEAGVGLGIGLCSIPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEINDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVEGVKFGKDRHQWSLEGVKRLESSWHGRPTLEKEREKHSAPPHRRAQKIMVRSSSDSSYMSGSPGGSPCSAGAEPQPSEREGSTHSPSLSPGEEQEPCPGVPSRPQQESPPLPESLERESHPPLRLKKSFEILVRKPTSSKPKPPPRKYFKNDSEPQKKLEEKEKVTDPSGHTLPTCSQETRELLPLLLQEDTAGRAPCTAACCPGPAASTQTSSSTEGESRRSASPETPASPGKHPLLKRQARMDYSFDITAEDPWVRISDCIKNLFSPIMSENHSHTPLQPNTSLGEEDGTQGCPEGGLSKMDAANGAPRVYKSADGSTVKKGPPVAPKPAWFRQSLKGLRNRAPDPRRPPEVASAIQPTPVSRDPPGPQPQASSSIRQRISSFENFGSSQLPDRGVQRLSLQPSSGETTKFPGKQDGGRFSGLLGQGATVTAKHRQTEVESMSTTFPNSSEVRDPGLPESPPPGQRPSTKALSPDPLLRLLTTQSEDTQGPGLKMPSQRARSFPLTRTQSCETKLLDEKASKLYSISSQLSSAVMKSLLCLPSSVSCGQITCIPKERVSPKSPCNNSSAAEGFGEAMASDTGFSLNLSELREYSEGLTEPGETEDRNHCSSQAGQSVISLLSAEELEKLIEEVRVLDEATLKQLDSIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGATHNDALAILRQARDPRQAVIVTRRTTVEATHDLNSSTDSAASASAASDISVESKEATVCTVTLEKTSAGLGFSLEGGKGSLHGDKPLTINRIFKGTEQGEMVQPGDEILQLAGTAVQGLTRFEAWNVIKALPDGPVTIVIRRTSLQCKQTTASADS

O54824-2

  • Name
    2
  • Synonyms
    Pro-IL-16
  • Note
    Produced by alternative promoter usage. Is proteolytically processed to yield IL-16.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
D3Z3C7D3Z3C7_MOUSEIl1629
D6RI15D6RI15_MOUSEIl16238

Features

Showing features for alternative sequence, compositional bias, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0374601-698in isoform 2
Compositional bias104-146Polar residues
Sequence conflict264in Ref. 5; BAD90484
Compositional bias480-497Basic and acidic residues
Compositional bias505-519Polar residues
Compositional bias531-545Polar residues
Compositional bias568-588Basic and acidic residues
Compositional bias600-623Basic and acidic residues
Compositional bias660-682Polar residues
Compositional bias729-745Polar residues
Sequence conflict733in Ref. 1; AAC04383
Compositional bias825-868Polar residues
Compositional bias887-908Polar residues
Sequence conflict921in Ref. 2; AAC16039
Compositional bias935-949Polar residues
Sequence conflict1067in Ref. 2; AAC16039
Sequence conflict1224in Ref. 2; AAC16039
Sequence conflict1262-1264in Ref. 1; AAC04383

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF006001
EMBL· GenBank· DDBJ
AAC04383.1
EMBL· GenBank· DDBJ
mRNA
AF017111
EMBL· GenBank· DDBJ
AAC16039.1
EMBL· GenBank· DDBJ
mRNA
AF175292
EMBL· GenBank· DDBJ
AAD55393.1
EMBL· GenBank· DDBJ
mRNA
AK038319
EMBL· GenBank· DDBJ
BAC29967.1
EMBL· GenBank· DDBJ
mRNA
AK169551
EMBL· GenBank· DDBJ
BAE41224.1
EMBL· GenBank· DDBJ
mRNA
AK220455
EMBL· GenBank· DDBJ
BAD90484.1
EMBL· GenBank· DDBJ
mRNA
CH466543
EMBL· GenBank· DDBJ
EDL06877.1
EMBL· GenBank· DDBJ
Genomic DNA
BC026894
EMBL· GenBank· DDBJ
AAH26894.1
EMBL· GenBank· DDBJ
mRNA
BC058709
EMBL· GenBank· DDBJ
AAH58709.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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