The TGF-beta1 target WISP1 is highly expressed in liver cirrhosis and cirrhotic HCC microenvironment and involved in pro- and anti-tumorigenic effects.
noncanonical Wnt signaling participates in VILI by modulating WISP1 expression which has been previously noted as critical for VILI development. Therefore the noncanonical Wnt signaling pathway may provide a preventive and therapeutic target in VILI.
Data revealed that reconstituted overexpression of WISP-1 could largely reverse the Notch1-/--induced metastasis-promoting effect of mesenchymal stem cell-derived stromal fibroblasts (MSC-DF); thus demonstrating that the Notch1-determined melanoma metastasis-regulating role of MSC-DF is mediated primarily by WISP-1.
One of the most striking new findings was up-regulation of mRNA for the matricellular protein WNT1-inducible signaling pathway protein 1 (CCN4) in metastatic cells; increased protein expression was verified by immunoblotting and immunocytochemistr
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