O54440 · O54440_PSEAI
- Protein3-oxoacyl-[acyl-carrier-protein] synthase 2
- GenefabF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids414 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.
Catalytic activity
- (9Z)-hexadecenoyl-[ACP] + malonyl-[ACP] + H+ = 3-oxo-(11Z)-octadecenoyl-[ACP] + holo-[ACP] + CO2
- a fatty acyl-[ACP] + malonyl-[ACP] + H+ = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2
Pathway
Lipid metabolism; fatty acid biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 164 | For beta-ketoacyl synthase activity | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 3-oxoacyl-[acyl-carrier-protein] synthase activity | |
Biological Process | fatty acid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-oxoacyl-[acyl-carrier-protein] synthase 2
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionO54440
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 119 | Interchain | |||
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 3-411 | Ketosynthase family 3 (KS3) | |||
Sequence similarities
Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length414
- Mass (Da)43,497
- Last updated1998-06-01 v1
- MD5 Checksum84D87146130FFCFE4C20E8832418F2FA
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U91631 EMBL· GenBank· DDBJ | AAB94396.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CVVU01000210 EMBL· GenBank· DDBJ | CRP17976.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WOAD01000006 EMBL· GenBank· DDBJ | MUI35440.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WXZT01000011 EMBL· GenBank· DDBJ | MZZ13696.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NFFZ01000002 EMBL· GenBank· DDBJ | OTI65027.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QORE01000159 EMBL· GenBank· DDBJ | RCI75519.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NSNE01000001 EMBL· GenBank· DDBJ | RPM23427.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP136986 EMBL· GenBank· DDBJ | WOS80159.1 EMBL· GenBank· DDBJ | Genomic DNA |