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O52792 · HMO_AMYOR

Function

function

Catalyzes the oxidation of p-hydroxymandelate to p-hydroxybenzoylformate in the biosynthesis of L-(4-hydroxyphenyl)glycine and L-(3,5-dihydroxyphenyl)glycine, 2 non-proteinogenic amino acids occurring in the vancomycin group of antibiotics.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Pathway

Antibiotic biosynthesis; vancomycin biosynthesis.

Features

Showing features for binding site, active site.

135750100150200250300350
Type
IDPosition(s)Description
Binding site126FMN (UniProtKB | ChEBI)
Binding site128a 2-oxocarboxylate (UniProtKB | ChEBI)
Binding site154FMN (UniProtKB | ChEBI)
Binding site163a 2-oxocarboxylate (UniProtKB | ChEBI)
Binding site228FMN (UniProtKB | ChEBI)
Active site252Proton acceptor
Binding site255a 2-oxocarboxylate (UniProtKB | ChEBI)
Binding site283-287FMN (UniProtKB | ChEBI)
Binding site306-307FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionFMN binding
Molecular FunctionL-lactate dehydrogenase activity
Molecular Functionoxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
Biological Processvancomycin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      hmo

Organism names

Accessions

  • Primary accession
    O52792

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004304411-3574-hydroxymandelate oxidase

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-357FMN hydroxy acid dehydrogenase

Sequence similarities

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    357
  • Mass (Da)
    37,832
  • Last updated
    1998-06-01 v1
  • MD5 Checksum
    46D2EA1E201A933DDF5A6987CDFD0A30
MTYVSLADLERAARDVLPGEIFDFLAGGSGTEASLVANRTALERVFVIPRMLRDLTDVTTEIDIFGRRAALPMAVAPVAYQRLFHPEGELAVARAARDAGVPYTICTLSSVSLEEIAAVGGRPWFQLYWLRDEKRSLDLVRRAEDAGCEAIVFTVDVPWMGRRLRDMRNGFALPEWVTAANFDAGTAAHRRTQGVSAVADHTAREFAPATWESVEAVRAHTDLPVVLKGILAVEDARRAVDAGAGGIVVSNHGGRQLDGAVPGIEMLGEIVAAVSGGCEVLVDGGIRSGGDVLKATALGASAVLVGRPVMWALAAAGQDGVRQLLELLAEEVRDAMGLAGCESVGAARRLNTKLGVV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ223998
EMBL· GenBank· DDBJ
CAA11762.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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