O51752 · COABC_BORBU
- ProteinCoenzyme A biosynthesis bifunctional protein CoaBC
- GenecoaBC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids390 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
Catalytic activity
- H+ + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 FMN per subunit.
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 156 | Proton donor | ||||
Sequence: C | ||||||
Binding site | 277 | CTP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 287 | CTP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 304-307 | CTP (UniProtKB | ChEBI) | ||||
Sequence: PDII | ||||||
Binding site | 323 | CTP (UniProtKB | ChEBI) | ||||
Sequence: F | ||||||
Binding site | 338 | CTP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 342 | CTP (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | FMN binding | |
Molecular Function | metal ion binding | |
Molecular Function | phosphopantothenate--cysteine ligase activity | |
Molecular Function | phosphopantothenoylcysteine decarboxylase activity | |
Biological Process | coenzyme A biosynthetic process | |
Biological Process | pantothenate catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCoenzyme A biosynthesis bifunctional protein CoaBC
- Alternative names
Including 2 domains:
- Recommended namePhosphopantothenoylcysteine decarboxylase
- EC number
- Short namesPPC decarboxylase ; PPC-DC
- Alternative names
- Recommended namePhosphopantothenate--cysteine ligase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Spirochaetota > Spirochaetia > Spirochaetales > Borreliaceae > Borreliella
Accessions
- Primary accessionO51752
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000232692 | 1-390 | Coenzyme A biosynthesis bifunctional protein CoaBC | |||
Sequence: MDKNKHILIGICGGIASYKSVYIVSSLVKLGYKVKVIMTQNATKFITPLTLETISKNKIITNLWDLDHNEVEHIKIAKWAHLILVIPATYNTISKIASGIADDALTTIISASTAPTYFAIAMNNIMYSNPILKENIKKLKTYNYKFIEPDKGFLACSSNALGRLKNEDKIIKIILNEFNQKDYLKNKKILITASRTEELIDPIRYFSNTSTGKMGFCLAQEAVKLGAQVTIITGPTNENDPEGVNIIKIKTAMEMYKEALKIYNKFEIIIGAAAVADFKPKHIFNSKIKKNKINRLYIKLVKNPDIIQHIGHNKLKNQIVIGFCAENSKNLIQKAKEKLKKKNLDFIIANELKYFGSKLNKVYIINKQSIKELPEMEKSEVAKEILKILY |
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-188 | Phosphopantothenoylcysteine decarboxylase | ||||
Sequence: MDKNKHILIGICGGIASYKSVYIVSSLVKLGYKVKVIMTQNATKFITPLTLETISKNKIITNLWDLDHNEVEHIKIAKWAHLILVIPATYNTISKIASGIADDALTTIISASTAPTYFAIAMNNIMYSNPILKENIKKLKTYNYKFIEPDKGFLACSSNALGRLKNEDKIIKIILNEFNQKDYLKNKK | ||||||
Region | 189-390 | Phosphopantothenate--cysteine ligase | ||||
Sequence: ILITASRTEELIDPIRYFSNTSTGKMGFCLAQEAVKLGAQVTIITGPTNENDPEGVNIIKIKTAMEMYKEALKIYNKFEIIIGAAAVADFKPKHIFNSKIKKNKINRLYIKLVKNPDIIQHIGHNKLKNQIVIGFCAENSKNLIQKAKEKLKKKNLDFIIANELKYFGSKLNKVYIINKQSIKELPEMEKSEVAKEILKILY |
Sequence similarities
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
In the C-terminal section; belongs to the PPC synthetase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length390
- Mass (Da)44,144
- Last updated1998-06-01 v1
- Checksum66868FAB172DE300
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE000783 EMBL· GenBank· DDBJ | AAC67145.1 EMBL· GenBank· DDBJ | Genomic DNA |