O48950 · TATB_MAIZE
- ProteinSec-independent protein translocase protein TATB, chloroplastic
- GeneTATB
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids243 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across the thylakoid membrane. Involved in delta pH-dependent protein transport required for chloroplast development, especially thylakoid membrane formation. TATC and TATB mediate precursor recognition, whereas TATA facilitates translocation.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | chloroplast thylakoid membrane | |
Molecular Function | proton motive force dependent protein transmembrane transporter activity | |
Biological Process | protein import into chloroplast thylakoid membrane | |
Biological Process | protein transport by the Tat complex |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameSec-independent protein translocase protein TATB, chloroplastic
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > PACMAD clade > Panicoideae > Andropogonodae > Andropogoneae > Tripsacinae > Zea
Accessions
- Primary accessionO48950
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Plastid, chloroplast thylakoid membrane ; Single-pass membrane protein
Note: The C-terminus is located in the stroma.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 68-69 | Lumenal | ||||
Sequence: AS | ||||||
Transmembrane | 70-90 | Helical | ||||
Sequence: LFGVGAPEALVIGVVALLVFG | ||||||
Topological domain | 91-243 | Stromal | ||||
Sequence: PKGLAEVARNLGKTLRAFQPTIRELQDVSREFRSTLEREIGIDEVSQSTNYRPTTMNNNQQPAADPNVKPEPAPYTSEELMKVTEEQIAASAAAAWNPQQPATSQQQEEAPTTPRSEDAPTSGGSDGPAAPARAVSDSDPNQVNKSQKAEGER |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Seedling lethality. Non-photosynthetic mutants possess near normal pigment levels but lack one or more elements of the electron transport activity in chloroplasts. Defects in protein targeting across chloroplast thylakoid membrane (PubMed:7664731).
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 11 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-67 | Chloroplast | ||||
Sequence: MTPTANLLLPAPPFVPISDVRRLQLPPRVRHQPRPCWKGVEWGSIQTRMVSSFVAVGSRTRRRNVIC | ||||||
Chain | PRO_0000419916 | 68-243 | Sec-independent protein translocase protein TATB, chloroplastic | |||
Sequence: ASLFGVGAPEALVIGVVALLVFGPKGLAEVARNLGKTLRAFQPTIRELQDVSREFRSTLEREIGIDEVSQSTNYRPTTMNNNQQPAADPNVKPEPAPYTSEELMKVTEEQIAASAAAAWNPQQPATSQQQEEAPTTPRSEDAPTSGGSDGPAAPARAVSDSDPNQVNKSQKAEGER |
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
In thylakoid membranes, TATC and TATB form a large receptor complex, containing about eight TATC-TATB pairs, which binds the precursor protein. Twin arginine signal peptide promotes pH-triggered docking of TATA oligomers to TATC-TATB receptor complex, inducing a conformational switch of TATA that results in activation of the translocase. TATA dissociates from TATC-TATB upon completion of translocation (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 129-165 | Disordered | ||||
Sequence: EIGIDEVSQSTNYRPTTMNNNQQPAADPNVKPEPAPY | ||||||
Compositional bias | 131-155 | Polar residues | ||||
Sequence: GIDEVSQSTNYRPTTMNNNQQPAAD | ||||||
Region | 178-243 | Disordered | ||||
Sequence: IAASAAAAWNPQQPATSQQQEEAPTTPRSEDAPTSGGSDGPAAPARAVSDSDPNQVNKSQKAEGER | ||||||
Compositional bias | 183-210 | Polar residues | ||||
Sequence: AAAWNPQQPATSQQQEEAPTTPRSEDAP |
Sequence similarities
Belongs to the TatB family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length243
- Mass (Da)26,326
- Last updated1998-06-01 v1
- Checksum98A1EE715BABA385
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A804MH45 | A0A804MH45_MAIZE | 732790 | 241 |
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 131-155 | Polar residues | ||||
Sequence: GIDEVSQSTNYRPTTMNNNQQPAAD | ||||||
Compositional bias | 183-210 | Polar residues | ||||
Sequence: AAAWNPQQPATSQQQEEAPTTPRSEDAP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF027808 EMBL· GenBank· DDBJ | AAC01571.1 EMBL· GenBank· DDBJ | mRNA | ||
CM007648 EMBL· GenBank· DDBJ | ONM17954.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
BT068439 EMBL· GenBank· DDBJ | ACN35336.1 EMBL· GenBank· DDBJ | mRNA |