O48915 · NDR1_ARATH

Function

function

Involved in disease resistance. Required for resistance conferred by multiple R genes recognizing different bacterial and oomycete pathogen isolates like avirulent P.syringae or H.parasitica (downy mildew). Required for the establishment of hypersensitive response (HR) and systemic acquired resistance (SAR) after infection with the bacterial pathogen P.syringae DC3000 carrying avrRpt2. Required for resistance to the soilborne fungus V.longisporum. Interaction with RIN4 is required for the activation of the R gene RPS2 and RPS2-mediated resistance.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentplasma membrane
Cellular Componentside of membrane
Biological Processdefense response to bacterium
Biological Processdefense response to fungus
Biological Processdefense response to other organism
Biological Processplant-type hypersensitive response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein NDR1
  • Alternative names
    • Non-race specific disease resistance protein 1 (AtNDR1)

Gene names

    • Name
      NDR1
    • ORF names
      K10D20.24
    • Ordered locus names
      At3g20600

Organism names

  • Taxonomic identifier
  • Strains
    • cv. Aa-0
    • cv. Columbia
    • cv. Ei-2
    • cv. Nd-1
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    O48915

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype under normal growth condition. In case of infection, plants loose R gene resistance mediated by RPM1, RPS2, RPS5. Plants overexpressing NDR1 show enhanced resistance against the virulent strain of the bacterial pathogen Pst DC3000.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis1No effect on the interaction with RIN4.
Mutagenesis2No effect on the interaction with RIN4.
Mutagenesis3No effect on the interaction with RIN4.
Mutagenesis4Loss of interaction with RIN4.
Mutagenesis5Loss of interaction with RIN4.
Mutagenesis6No effect on the interaction with RIN4.
Mutagenesis7No effect on the interaction with RIN4.
Mutagenesis8No effect on the interaction with RIN4.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 20 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain, glycosylation, lipidation, propeptide.

Type
IDPosition(s)Description
Signal1-38
ChainPRO_000040365239-195Protein NDR1
Glycosylation62N-linked (GlcNAc...) asparagine
Glycosylation88N-linked (GlcNAc...) asparagine
Glycosylation93N-linked (GlcNAc...) asparagine
Glycosylation98N-linked (GlcNAc...) asparagine
Glycosylation107N-linked (GlcNAc...) asparagine
Glycosylation132N-linked (GlcNAc...) asparagine
Glycosylation142N-linked (GlcNAc...) asparagine
Lipidation195GPI-anchor amidated aspartate
PropeptidePRO_0000403653196-219Removed in mature form

Post-translational modification

N-glycosylated.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with RIN4 (via C-terminus).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY O48915RIN4 Q8GYN53EBI-2314492, EBI-2270391

Protein-protein interaction databases

Family & Domains

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    219
  • Mass (Da)
    24,674
  • Last updated
    1998-06-01 v1
  • Checksum
    DD53EF984F89D0DD
MNNQNEDTEGGRNCCTCCLSFIFTAGLTSLFLWLSLRADKPKCSIQNFFIPALGKDPNSRDNTTLNFMVRCDNPNKDKGIYYDDVHLNFSTINTTKINSSALVLVGNYTVPKFYQGHKKKAKKWGQVKPLNNQTVLRAVLPNGSAVFRLDLKTQVRFKIVFWKTKRYGVEVGADVEVNGDGVKAQKKGIKMKKSDSSFPLRSSFPISVLMNLLVFFAIR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF021346
EMBL· GenBank· DDBJ
AAB95208.1
EMBL· GenBank· DDBJ
Genomic DNA
EF470696
EMBL· GenBank· DDBJ
ABR45925.1
EMBL· GenBank· DDBJ
Genomic DNA
EF470697
EMBL· GenBank· DDBJ
ABR45926.1
EMBL· GenBank· DDBJ
Genomic DNA
EF470704
EMBL· GenBank· DDBJ
ABR45933.1
EMBL· GenBank· DDBJ
Genomic DNA
EF470706
EMBL· GenBank· DDBJ
ABR45935.1
EMBL· GenBank· DDBJ
Genomic DNA
AP000410
EMBL· GenBank· DDBJ
BAB01168.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE76402.1
EMBL· GenBank· DDBJ
Genomic DNA
BT002004
EMBL· GenBank· DDBJ
AAN72015.1
EMBL· GenBank· DDBJ
mRNA
BT006267
EMBL· GenBank· DDBJ
AAP13375.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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