O48915 · NDR1_ARATH
- ProteinProtein NDR1
- GeneNDR1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids219 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in disease resistance. Required for resistance conferred by multiple R genes recognizing different bacterial and oomycete pathogen isolates like avirulent P.syringae or H.parasitica (downy mildew). Required for the establishment of hypersensitive response (HR) and systemic acquired resistance (SAR) after infection with the bacterial pathogen P.syringae DC3000 carrying avrRpt2. Required for resistance to the soilborne fungus V.longisporum. Interaction with RIN4 is required for the activation of the R gene RPS2 and RPS2-mediated resistance.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Cellular Component | side of membrane | |
Biological Process | defense response to bacterium | |
Biological Process | defense response to fungus | |
Biological Process | defense response to other organism | |
Biological Process | plant-type hypersensitive response |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameProtein NDR1
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionO48915
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
No visible phenotype under normal growth condition. In case of infection, plants loose R gene resistance mediated by RPM1, RPS2, RPS5. Plants overexpressing NDR1 show enhanced resistance against the virulent strain of the bacterial pathogen Pst DC3000.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Mutagenesis | 1 | No effect on the interaction with RIN4. | |||
Mutagenesis | 2 | No effect on the interaction with RIN4. | |||
Mutagenesis | 3 | No effect on the interaction with RIN4. | |||
Mutagenesis | 4 | Loss of interaction with RIN4. | |||
Mutagenesis | 5 | Loss of interaction with RIN4. | |||
Mutagenesis | 6 | No effect on the interaction with RIN4. | |||
Mutagenesis | 7 | No effect on the interaction with RIN4. | |||
Mutagenesis | 8 | No effect on the interaction with RIN4. | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 20 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, chain, glycosylation, lipidation, propeptide.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-38 | ||||
Chain | PRO_0000403652 | 39-195 | Protein NDR1 | ||
Glycosylation | 62 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 88 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 93 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 98 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 107 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 132 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 142 | N-linked (GlcNAc...) asparagine | |||
Lipidation | 195 | GPI-anchor amidated aspartate | |||
Propeptide | PRO_0000403653 | 196-219 | Removed in mature form | ||
Post-translational modification
N-glycosylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Interacts with RIN4 (via C-terminus).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | O48915 | RIN4 Q8GYN5 | 3 | EBI-2314492, EBI-2270391 |
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length219
- Mass (Da)24,674
- Last updated1998-06-01 v1
- ChecksumDD53EF984F89D0DD
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF021346 EMBL· GenBank· DDBJ | AAB95208.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF470696 EMBL· GenBank· DDBJ | ABR45925.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF470697 EMBL· GenBank· DDBJ | ABR45926.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF470704 EMBL· GenBank· DDBJ | ABR45933.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF470706 EMBL· GenBank· DDBJ | ABR45935.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP000410 EMBL· GenBank· DDBJ | BAB01168.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE76402.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT002004 EMBL· GenBank· DDBJ | AAN72015.1 EMBL· GenBank· DDBJ | mRNA | ||
BT006267 EMBL· GenBank· DDBJ | AAP13375.1 EMBL· GenBank· DDBJ | mRNA |