O45717 · NUD2_CAEEL

Function

function

Part of a complex with lis-1, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells (PubMed:20005871, PubMed:27697906).
Plays a role in GABAergic synaptic vesicle localization in the ventral nerve cord (PubMed:16996038).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcentrosome
Cellular Componentkinesin complex
Cellular Componentkinetochore
Cellular Componentmicrotubule associated complex
Cellular Componentnuclear envelope
Cellular Componentsynapse
Molecular Functionmicrotubule binding
Biological Processcell migration
Biological Processcentrosome localization
Biological Processchromosome segregation
Biological Processestablishment of chromosome localization
Biological Processestablishment of mitotic spindle orientation
Biological Processmicrotubule nucleation
Biological Processmitotic centrosome separation
Biological Processnuclear migration
Biological Processnuclear migration along microfilament
Biological Processsynaptic transmission, GABAergic
Biological Processsynaptic vesicle transport
Biological Processvesicle transport along microtubule

Names & Taxonomy

Protein names

  • Recommended name
    Protein nud-2

Gene names

    • Name
      nud-2
    • ORF names
      R11A5.2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    O45717

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

RNAi-mediated knockdown results in viable animals, but a small, but significant number of animals have nuclear migration defects in hyp7 hypodermal precursor cells (PubMed:20005871).
RNAi-mediated knockdown results in an abnormal distribution of GABAergic synaptic vesicles at synaptic termini of the ventral nerve cord (PubMed:16996038).
RNAi-mediated knockdown in combination with exposure to pentylenetetrazole, a GABA antagonist that induces seizures, results in impaired locomotion, stiffened appearance and an increased convulsion incidence as compared to wild-type animals (PubMed:16996038).

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis239-293Abolishes interaction with unc-83 isoform c.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004435161-293Protein nud-2

Proteomic databases

Expression

Tissue specificity

Expressed in ventral cord neurons, the pharynx, seam cells of the hypodermis and in vulval muscle cells.

Gene expression databases

    • WBGene00011230Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues

Interaction

Subunit

Component of a dynein-regulating complex composed of at least lis-1 and nud-2 (PubMed:20005871).
Interacts with lis-1; the interaction is direct (PubMed:16996038).
Interacts (via C-terminus) with unc-83; the interaction is direct, and is required for recruitment of nud-2 to the nuclear envelope (PubMed:20005871).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY O45717magu-4 Q203984EBI-326083, EBI-322716
BINARY O45717unc-83 Q23064-35EBI-326083, EBI-2902257
View interactors in UniProtKB
View CPX-1389 in Complex Portal

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for coiled coil, region.

TypeIDPosition(s)Description
Coiled coil36-147
Region239-293Required for interaction with unc-83 isoform c

Sequence similarities

Belongs to the nudE family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    293
  • Mass (Da)
    34,265
  • Last updated
    1998-06-01 v1
  • Checksum
    84E075C3DC96C3D9
MDLSEDQIRGLPHHELLGHFLQMREEFNEFQTSSAEIEKMMDSELDDLKTQLKKAETRVQQMTTEQIRNKDRQDDSRVQFAQVEEQLRRENSHLHEQCESQRERIRKLEQRNDVLETSERNKEYLASDLGSKLDHAIEKIAMLESELYERQVAAEEMHRLREEQLRTTERPRLIVEPLRNDPEILPDEPSPGPSKEEFKMSSEDVFMEDVQHHEDVRMEETIAKIDEVRIDDNKNIQEKSQRVSTGTGAGACINRIVKDLMTKVERLDSILSTIRVSNNSSNNNSSHLTTTRA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284601
EMBL· GenBank· DDBJ
CAB05597.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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