O44326 · HMP2_CAEEL

  • Protein
    Beta-catenin-like protein hmp-2
  • Gene
    hmp-2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Required for cell migration during body enclosure and cell shape changes during body elongation (PubMed:9531567).
Plays a role in recruitment of the cadherin protein hmr-1 to adherens junctions (PubMed:26412237).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentadherens junction
Cellular Componentcatenin complex
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionalpha-catenin binding
Molecular Functioncadherin binding
Molecular Functionmolecular function inhibitor activity
Molecular Functionnuclear receptor binding
Molecular Functionprotein domain specific binding
Molecular Functionprotein kinase binding
Molecular Functionprotein phosphatase binding
Molecular Functiontranscription coactivator activity
Biological Processcanonical Wnt signaling pathway
Biological Processcell migration
Biological Processcell migration involved in gastrulation
Biological Processcell-cell adhesion
Biological Processcell-cell adhesion mediated by cadherin
Biological Processcortical actin cytoskeleton organization
Biological Processembryo development ending in birth or egg hatching
Biological Processembryonic body morphogenesis
Biological Processestablishment of mitotic spindle orientation
Biological Processleft/right axis specification
Biological Processnegative regulation of cell division
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of protein localization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Beta-catenin-like protein hmp-2
  • Alternative names
    • Protein humpback-2

Gene names

    • Name
      hmp-2
    • ORF names
      K05C4.6

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    O44326

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Worms have strong elongation defects (PubMed:9531567).
RNAi-mediated knockdown results in failure of cadherin protein hmr-1 to localize to adherens junctions, but results in its accumulation along the basolateral membrane of the cell (PubMed:26412237).

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis271In zu364; embryonic lethal with embryos failing to elongate and displaying a humpback phenotype in which embryos contain a dorsal hump. Localizes exclusively to the cytoplasm rather than adherens junctions.
Mutagenesis599Phosphomimetic mutation. Initially localizes to adherens junctions, but the distribution at the junctions becomes punctate during late embryonic elongation with excursions forming orthogonal to the junctions between lateral seam cells and the dorsal and ventral neighboring cells. Defects in F-actin filament organization that include wavy and irregularly spaced filaments and the occasional aggregation of multiple bundles at single points along the adherens junction.
Mutagenesis599Phospho-null mutation. No obvious phenotype.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002686471-678Beta-catenin-like protein hmp-2

Proteomic databases

PTM databases

Expression

Tissue specificity

Epidermal cells.

Developmental stage

Present in all embryonic blastomeres at early stages of development (at protein level).

Gene expression databases

Interaction

Subunit

Component of a core catenin-cadherin complex consisting of hmr-1, hmp-1 and hmp-2; the complex localizes to adherens junctions (PubMed:25850673).
Interacts with hmr-1; the interaction is direct (PubMed:10952315, PubMed:25850673, PubMed:26412237).
May interact with hmp-1 (PubMed:11560894).
Interacts with frk-1 (PubMed:20805471).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY O44326hmr-1 Q967F45EBI-317320, EBI-2528888

Protein-protein interaction databases

Family & Domains

Features

Showing features for repeat.

TypeIDPosition(s)Description
Repeat153-192ARM 1
Repeat280-319ARM 2
Repeat320-359ARM 3
Repeat362-403ARM 4
Repeat409-448ARM 5

Sequence similarities

Belongs to the beta-catenin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    678
  • Mass (Da)
    74,511
  • Last updated
    1998-06-01 v1
  • Checksum
    E6C7ED51F6241232
MLLHSTNSYSIFTDHEVETRTSRIRSAMFPDWIPPTSAAEATNSTTSIVEMMQMPTQQLKQSVMDLLTYEGSNDMSGLSLPDLVKLMCDHDESVVARAVHRAYMLSREDPNFFNAPGFDHRSFVEALMAASKSSNVNVRRNAIGALSHMSEQRGGPLLIFRSGGLAEIIRMLYDSLESVVHYAVTTLRNLLMHVSDSRAQARALNAVEALTPHLHKTNPKLLAQVADGLYFLLIDDAPSKITFLSLLGPQILVSILREYSDHRKLIYTVVRCIRSLSVCPSNKPALISLGCLPALYVELCTAKDERSQTAILVAMRNLSDSATNEENLTQLIIKLLEIIRVANDGMTACACGTLSNLTCNNTRNKQTVCSHGGIDALVTAIRRLPEVEEVTEPALCALRHCTARHSLAEEAQSELRFCQAFPVILDQLETLRTPVIKAALGVIRNSALLQTNLIELTQEQTANGHTAVSLTMDILRRAITAIEENPDIAVDGVPMWGVIEGAVSALHQLANHPAVAAACCDDIGQVGNPECPPFLDLLHRLLAHPRLGSMDDEVLEREILGLLYQLSKRPDGARAVESTGVSALLMESRGSQYKSVVTYANGVLSNLKRGDSAAIMNMSNSYDYEMSGSAADWQRDGLERELFAEMYPTNDGGHSESINMALNNSQMRPNHNWYDTDL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
H2L2I2H2L2I2_CAEELhmp-2704

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF016853
EMBL· GenBank· DDBJ
AAB94552.1
EMBL· GenBank· DDBJ
mRNA
Z81564
EMBL· GenBank· DDBJ
CAB04572.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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