O43861 · ATP9B_HUMAN

  • Protein
    Probable phospholipid-transporting ATPase IIB
  • Gene
    ATP9B
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

Caution

It is uncertain whether Met-1 or Met-53 is the initiator.

Catalytic activity

  • ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.
    EC:7.6.2.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for active site, binding site.

111471002003004005006007008009001,0001,100
TypeIDPosition(s)Description
Active site4684-aspartylphosphate intermediate
Binding site468ATP (UniProtKB | ChEBI)
Binding site468Mg2+ (UniProtKB | ChEBI)
Binding site469ATP (UniProtKB | ChEBI)
Binding site470ATP (UniProtKB | ChEBI)
Binding site470Mg2+ (UniProtKB | ChEBI)
Binding site591ATP (UniProtKB | ChEBI)
Binding site633ATP (UniProtKB | ChEBI)
Binding site638ATP (UniProtKB | ChEBI)
Binding site657ATP (UniProtKB | ChEBI)
Binding site686ATP (UniProtKB | ChEBI)
Binding site687ATP (UniProtKB | ChEBI)
Binding site766ATP (UniProtKB | ChEBI)
Binding site767ATP (UniProtKB | ChEBI)
Binding site768ATP (UniProtKB | ChEBI)
Binding site848ATP (UniProtKB | ChEBI)
Binding site854ATP (UniProtKB | ChEBI)
Binding site874Mg2+ (UniProtKB | ChEBI)
Binding site877ATP (UniProtKB | ChEBI)
Binding site878ATP (UniProtKB | ChEBI)
Binding site878Mg2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendosome
Cellular Componentperinuclear region of cytoplasm
Cellular Componentplasma membrane
Cellular Componenttrans-Golgi network
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATPase-coupled intramembrane lipid transporter activity
Molecular Functionmagnesium ion binding
Biological Processendocytosis
Biological Processphospholipid translocation
Biological Processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable phospholipid-transporting ATPase IIB
  • EC number
  • Alternative names
    • ATPase class II type 9B

Gene names

    • Name
      ATP9B
    • Synonyms
      ATPIIB, NEO1L
    • ORF names
      HUSSY-20

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    O43861
  • Secondary accessions
    • O60872
    • Q08AD8
    • Q08AD9

Proteomes

Organism-specific databases

Subcellular Location

Golgi apparatus, trans-Golgi network membrane
; Multi-pass membrane protein
Note: Efficient exit from the endoplasmic reticulum does not require TMEM30A, nor TMEM30B.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-146Cytoplasmic
Transmembrane147-168Helical
Topological domain169-173Extracellular
Transmembrane174-196Helical
Topological domain197-380Cytoplasmic
Transmembrane381-401Helical
Topological domain402-409Extracellular
Transmembrane410-431Helical
Topological domain432-930Cytoplasmic
Transmembrane931-951Helical
Topological domain952-963Extracellular
Transmembrane964-982Helical
Topological domain983-1012Cytoplasmic
Transmembrane1013-1031Helical
Topological domain1032-1038Extracellular
Transmembrane1039-1061Helical
Topological domain1062-1067Cytoplasmic
Transmembrane1068-1088Helical
Topological domain1089-1105Extracellular
Transmembrane1106-1130Helical
Topological domain1131-1147Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_04755739in dbSNP:rs4078115
Natural variantVAR_061037108in dbSNP:rs34938281
Natural variantVAR_047558504in dbSNP:rs36034863
Natural variantVAR_047559732in dbSNP:rs585033

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,329 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00000463771-1147UniProtProbable phospholipid-transporting ATPase IIB
Modified residue (large scale data)521PRIDEPhosphothreonine

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region503-535Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

O43861-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,147
  • Mass (Da)
    129,304
  • Last updated
    2008-11-25 v4
  • Checksum
    1C3787BF07EFD637
MADQIPLYPVRSAAAAAANRKRAAYYSAAGPRPGADRHSRYQLEDESAHLDEMPLMMSEEGFENEESDYHTLPRARIMQRKRGLEWFVCDGWKFLCTSCCGWLINICRRKKELKARTVWLGCPEKCEEKHPRNSIKNQKYNVFTFIPGVLYEQFKFFLNLYFLVISCSQFVPALKIGYLYTYWAPLGFVLAVTMTREAIDEFRRFQRDKEVNSQLYSKLTVRGKVQVKSSDIQVGDLIIVEKNQRIPSDMVFLRTSEKAGSCFIRTDQLDGETDWKLKVAVSCTQQLPALGDLFSISAYVYAQKPQMDIHSFEGTFTREDSDPPIHESLSIENTLWASTIVASGTVIGVVIYTGKETRSVMNTSNPKNKVGLLDLELNRLTKALFLALVALSIVMVTLQGFVGPWYRNLFRFLLLFSYIIPISLRVNLDMGKAVYGWMMMKDENIPGTVVRTSTIPEELGRLVYLLTDKTGTLTQNEMIFKRLHLGTVSYGADTMDEIQSHVRDSYSQMQSQAGGNNTGSTPLRKAQSSAPKVRKSVSSRIHEAVKAIVLCHNVTPVYESRAGVTEETEFAEADQDFSDENRTYQASSPDEVALVQWTESVGLTLVSRDLTSMQLKTPSGQVLSFCILQLFPFTSESKRMGVIVRDESTAEITFYMKGADVAMSPIVQYNDWLEEECGNMAREGLRTLVVAKKALTEEQYQDFESRYTQAKLSMHDRSLKVAAVVESLEREMELLCLTGVEDQLQADVRPTLEMLRNAGIKIWMLTGDKLETATCIAKSSHLVSRTQDIHIFRQVTSRGEAHLELNAFRRKHDCALVISGDSLEVCLKYYEHEFVELACQCPAVVCCRCSPTQKARIVTLLQQHTGRRTCAIGDGGNDVSMIQAADCGIGIEGKEGKQASLAADFSITQFRHIGRLLMVHGRNSYKRSAALGQFVMHRGLIISTMQAVFSSVFYFASVPLYQGFLMVGYATIYTMFPVFSLVLDQDVKPEMAMLYPELYKDLTKGRSLSFKTFLIWVLISIYQGGILMYGALVLFESEFVHVVAISFTALILTELLMVALTVRTWHWLMVVAEFLSLGCYVSSLAFLNEYFGIGRVSFGAFLDVAFITTVTFLWKVSAITVVSCLPLYVLKYLRRKLSPPSYCKLAS

O43861-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 13 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
K7EII3K7EII3_HUMANATP9B145
K7EJG1K7EJG1_HUMANATP9B100
B4DJ94B4DJ94_HUMANATP9B188
A0A0J9YYD2A0A0J9YYD2_HUMANATP9B98
A0A0G2JNU9A0A0G2JNU9_HUMANATP9B39
K7EJP9K7EJP9_HUMANATP9B140
K7EJS3K7EJS3_HUMANATP9B18
K7EL57K7EL57_HUMANATP9B80
K7EQ39K7EQ39_HUMANATP9B37
K7EPH4K7EPH4_HUMANATP9B289
K7EQQ5K7EQQ5_HUMANATP9B200
K7ES39K7ES39_HUMANATP9B140
K7ERE0K7ERE0_HUMANATP9B192

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict886in Ref. 4; AAC05243
Sequence conflict1006in Ref. 4; AAC05243
Sequence conflict1020in Ref. 4; AAC05243
Sequence conflict1036in Ref. 4; AAC05243
Sequence conflict1073in Ref. 4; AAC05243
Alternative sequenceVSP_0357901092-1102in isoform 2
Sequence conflict1095in Ref. 4; AAC05243
Sequence conflict1103in Ref. 4; AAC05243
Sequence conflict1131in Ref. 4; AAC05243

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC023090
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC099689
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC104423
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC125437
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC125219
EMBL· GenBank· DDBJ
AAI25220.1
EMBL· GenBank· DDBJ
mRNA
BC125220
EMBL· GenBank· DDBJ
AAI25221.1
EMBL· GenBank· DDBJ
mRNA
AK097757
EMBL· GenBank· DDBJ
-mRNA No translation available.
U78978
EMBL· GenBank· DDBJ
AAC05243.1
EMBL· GenBank· DDBJ
mRNA
AJ006268
EMBL· GenBank· DDBJ
CAA06934.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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