The purpose of this study was to determine the diversity and frequency of RHD-CE genotypes predicting partial antigens in patients with sickle cell disease and in African Brazilian donors in order to find through the use of RH genotyping more closely matched donors for sickle cell disease patients who are alloimmunised to Rh antigens.
study 94.9% of the partial D samples revealed altered RHCE variant alleles and 5.7% of the samples with altered RHD allele predicted partial c partial e and the lack of the high prevalence hr(B) and hr(S) antigens.
sequence comparisons revealed high sequence similarity between Patr_RHbeta and Hosa_RHCE while the chimpanzee Rh gene closest to Hosa_RHD was not Patr_RHalpha but rather Patr_RHgamma
Six new RHCE alleles were identified namely RHCE*cE84A RHCE*ce202G RHCE*ce307T RHCE*Ce377G RHCE*ce697G 712G 733G 744C and RHCE*Ce733G in individuals of diverse racial origin.
An uneven distribution of RH variant alleles between Dogon and Fulani in Mali. A high incidence of predicted partial-C phenotype encoded by RHCE*Ce-D(4)-ce was found in Fulani.
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